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Novel Cardioprotective Antidiabetic Medications

New Content ItemThe thematic series focusses on two groups of antidiabetic medications that have demonstrated cardiovascular benefits with consistently reduced major adverse cardiac events, improvement in heart failure and diminished cardiovascular and all-cause mortality. Namely, these are the sodium-glucose cotransporter-2 inhibitors (SGLT2i, also called gliflozins) and the glucagon-like peptide-1 receptor agonists (GLP-1a, also called incretin mimetics).
Due to their cardioprotective effect, these compounds, as well as the GLP-1a "cousin" tirzepatide, represent a real breakthrough in antidiabetic therapeutics. Repurposing antidiabetic drugs for the treatment of cardiovascular diseases is a trend that may increase in a near future allowing the inclusion of new drugs when their underlying molecular mechanisms of action will be unveiled. 

We encourage submissions of research as well as review articles. 

  1. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in cardiovascular outcome trials in type 2 diabetes mellitus. However, the most convincing evidence was obtained in subj...

    Authors: Sara Piccini, Giuseppe Favacchio, Cristina Panico, Emanuela Morenghi, Franco Folli, Gherardo Mazziotti, Andrea Gerardo Lania and Marco Mirani
    Citation: Cardiovascular Diabetology 2023 22:69
  2. Patients with type 2 diabetes are at increased risk for cardiovascular diseases. Sodium-glucose transport 2 inhibitors (SGLT2i) have been shown to enhance cardiovascular health since their debut as a second-li...

    Authors: Pei-Chien Tsai, Wei-Jung Chuang, Albert Min-Shan Ko, Jui-Shuan Chen, Cheng-Hsun Chiu, Chun-Han Chen and Yung-Hsin Yeh
    Citation: Cardiovascular Diabetology 2023 22:57
  3. No study has compared the cardiovascular outcomes for sodium–glucose cotransporter-2 inhibitors (SGLT2i) head-to-head against other glucose-lowering therapies, including dipeptidyl peptidase 4 inhibitor (DDP4i...

    Authors: Jimmy Gonzalez, Benjamin A. Bates, Soko Setoguchi, Tobias Gerhard and Chintan V. Dave
    Citation: Cardiovascular Diabetology 2023 22:54
  4. Basal insulin glargine has a neutral effect on cardiovascular risk in type 2 diabetes (T2DM). In practice, basal insulin is often paired with a glucagon-like peptide-1 receptor agonist (GLP1-RA) or meal insuli...

    Authors: Ravi Retnakaran, Jiajie Pu, Chang Ye, Alexandra Emery, Caroline K. Kramer and Bernard Zinman
    Citation: Cardiovascular Diabetology 2023 22:50
  5. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium glucose cotransporter-2 inhibitors (SGLT-2i) demonstrated cardiovascular and renal protection. Whether their benefits occur also during hospitali...

    Authors: Filippo Trombara, Nicola Cosentino, Alice Bonomi, Monica Ludergnani, Paolo Poggio, Luigia Gionti, Marta Baviera, Pierluca Colacioppo, Maria Carla Roncaglioni, Olivia Leoni, Francesco Bortolan, Piergiuseppe Agostoni, Stefano Genovese and Giancarlo Marenzi
    Citation: Cardiovascular Diabetology 2023 22:26
  6. Increased acid sphingomyelinase (ASMase) activity is associated with insulin resistance and cardiac dysfunction. However, the effects of ASMase on diabetic cardiomyopathy (DCM) and the molecular mechanism(s) u...

    Authors: Ruijiao Liu, Tengfei Duan, Li Yu, Yongzhong Tang, Shikun Liu, Chunjiang Wang and Wei-Jin Fang
    Citation: Cardiovascular Diabetology 2023 22:25
  7. Epicardial adipose tissue (EAT) plays an important role in cardiometabolic risk. EAT is a modifiable risk factor and could be a potential therapeutic target for drugs that already show cardiovascular benefits. Th...

    Authors: Veronika A. Myasoedova, Valentina Parisi, Donato Moschetta, Vincenza Valerio, Maddalena Conte, Ilaria Massaiu, Michele Bozzi, Fabrizio Celeste, Dario Leosco, Guido Iaccarino, Stefano Genovese and Paolo Poggio
    Citation: Cardiovascular Diabetology 2023 22:23
  8. As indications for sodium-glucose co-transporter-2 inhibitors (SGLT2i) are expanding, a growing number of older adults have become candidates for treatment. We studied the safety profile of SGLT2i among older ...

    Authors: Adam Goldman, Boris Fishman, Gilad Twig, Emanuel Raschi, Tali Cukierman-Yaffe, Yonatan moshkovits, Alon Pomerantz, Ilan Ben-Zvi, Rachel Dankner and Elad Maor
    Citation: Cardiovascular Diabetology 2023 22:16
  9. The mechanism by which a sodium-glucose cotransporter inhibitor (SGLT2i) induces favorable effects on diabetes and cardiovascular diseases including heart failure (HF) remains poorly understood. Metabolomics i...

    Authors: Satoshi Katano, Toshiyuki Yano, Hidemichi Kouzu, Ryohei Nagaoka, Ryo Numazawa, Kotaro Yamano, Yusuke Fujisawa, Katsuhiko Ohori, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Masaki Katayose, Tatsuya Sato, Atsushi Kuno and Masato Furuhashi
    Citation: Cardiovascular Diabetology 2022 21:285
  10. Glucokinase activators (GKAs) are an emerging class of glucose lowering drugs that activate the glucose-sensing enzyme glucokinase (GK). Pending formal cardiovascular outcome trials, we applied two-sample Mend...

    Authors: Ke Wang, Mai Shi, Chuiguo Huang, Baoqi Fan, Andrea O. Y. Luk, Alice P. S. Kong, Ronald C. W. Ma, Juliana C. N. Chan and Elaine Chow
    Citation: Cardiovascular Diabetology 2022 21:192
  11. Tirzepatide is the first dual GIP/GLP-1 receptor co-agonist approved for the treatment of type 2 diabetes in the USA, Europe, and the UAE. Tirzepatide is an acylated peptide engineered to activate the GIP and ...

    Authors: Michael A. Nauck and David A. D‘Alessio
    Citation: Cardiovascular Diabetology 2022 21:169
  12. Incretin hormones are peptides released in the intestine in response to the presence of nutrients in its lumen. The main incretins are glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polyp...

    Authors: Enrique Z. Fisman and Alexander Tenenbaum
    Citation: Cardiovascular Diabetology 2021 20:225