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Nutrition and metabolism in health and disease

Lifestyle-related diseases such as diabetes and cancer represent one of the greatest challenges to health and wellbeing in the developed world. These complex disorders are difficult to treat effectively, and are increasingly prevalent as sedentary lifestyles and calorie-rich, nutrient-poor diets cause an obesity crisis throughout the developed world. The Metabolism, Diet and Disease conference aims to show how basic research on the biochemistry, cell biology and genetics of metabolism can address the major health problems of cancer, obesity, diabetes and insulin resistance, and can explain ageing and longevity.

In addition, the conference provides a forum to explore the role of lifestyle factors such as diet in disease. This cross-journal collection builds on these aims by using research from across the fields of nutrition, metabolism and oncology to investigate disease prevention and treatment using both lifestyle changes and pharmacological interventions.

The series aims to address the complex nature of these disorders by looking at the links between metabolism, lifestyle and disease. It combines research and reviews published in Nutrition & Metabolism, Diabetology & Metabolic Syndrome, Nutrition Journal, Cardiovascular Diabetology, Journal of Experimental & Clinical Cancer Research, Journal of Translational Medicine (Nutrition & Metabolism Section), Molecular Cancer and Cancer and Metabolism. We welcome further submissions on this topic.

If you have a manuscript that you would like to be considered for the series please submit it via the online submission system for the relevant journal, and state clearly in the covering letter that it is intended for this thematic series. Before submitting your manuscript, please read the 'instructions for authors', for the relevant journal.

Collection published: 28 May 2012
Last updated: 7 March 2013

  1. Calorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned...

    Authors: Stephen D Hursting, Sarah M Dunlap, Nikki A Ford, Marcie J Hursting and Laura M Lashinger
    Citation: Cancer & Metabolism 2013 1:10
  2. Metabolic reprogramming is a key event in tumorigenesis to support cell growth, and cancer cells frequently become both highly glycolytic and glutamine dependent. Similarly, T lymphocytes (T cells) modify thei...

    Authors: Andrew N Macintyre and Jeffrey C Rathmell
    Citation: Cancer & Metabolism 2013 1:5
  3. Tissue imaging of treatment-induced metabolic changes is useful for optimizing cancer therapies, but commonly used methods require trade-offs between assay sensitivity and spatial resolution. Nanostructure-Ini...

    Authors: Peter J O’Brien, Michelle Lee, Mary E Spilker, Cathy C Zhang, Zhengming Yan, Timothy C Nichols, Wenlin Li, Caroline H Johnson, Gary J Patti and Gary Siuzdak
    Citation: Cancer & Metabolism 2013 1:4
  4. Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregul...

    Authors: Beatrice Griffiths, Caroline A Lewis, Karim Bensaad, Susana Ros, Qifeng Zhang, Emma C Ferber, Sofia Konisti, Barrie Peck, Heike Miess, Philip East, Michael Wakelam, Adrian L Harris and Almut Schulze
    Citation: Cancer & Metabolism 2013 1:3
  5. While aerobic glycolysis is linked to unconstrained proliferation in cancer, less is known about its physiological role. Why this metabolic program that promotes tumor growth is preserved in the genome has thu...

    Authors: Timothy R Gershon, Andrew J Crowther, Andrey Tikunov, Idoia Garcia, Ryan Annis, Hong Yuan, C Ryan Miller, Jeffrey Macdonald, James Olson and Mohanish Deshmukh
    Citation: Cancer & Metabolism 2013 1:2
  6. Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknow...

    Authors: Ricardo Ribeiro, Cátia Monteiro, Virgínia Cunha, Maria José Oliveira, Mariana Freitas, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco Lobo, António Morais, Vítor Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Anabela Mota-Pinto, Carlos Lopes…
    Citation: Journal of Experimental & Clinical Cancer Research 2012 31:32
  7. Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a die...

    Authors: Juscelino Tovar, Anne Nilsson, Maria Johansson, Rickard Ekesbo, Ann-Margreth Åberg, Ulla Johansson and Inger Björck
    Citation: Nutrition & Metabolism 2012 9:29
  8. Visceral obesity and insulin resistance are associated with a postprandial accumulation of atherogenic chylomicron remnants that is difficult to modulate with lipid-lowering therapies. Dietary fish oil and exe...

    Authors: Karin M Slivkoff-Clark, Anthony P James and John C L Mamo
    Citation: Nutrition & Metabolism 2012 9:9
  9. Increased polyamine concentrations in the blood and urine of cancer patients reflect the enhanced levels of polyamine synthesis in cancer tissues arising from increased activity of enzymes responsible for poly...

    Authors: Kuniyasu Soda
    Citation: Journal of Experimental & Clinical Cancer Research 2011 30:95
  10. Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with multiple genetic aberrations. Several molecular pathways involved in the regulation of proliferation and cell death are implicated in th...

    Authors: Monica Marra, Ignazio M Sordelli, Angela Lombardi, Monica Lamberti, Luciano Tarantino, Aldo Giudice, Paola Stiuso, Alberto Abbruzzese, Rossella Sperlongano, Marina Accardo, Massimo Agresti, Michele Caraglia and Pasquale Sperlongano
    Citation: Journal of Translational Medicine 2011 9:171
  11. Considerable interest has been shown in the ability of caloric restriction (CR) to improve multiple parameters of health and to extend lifespan. CR is the reduction of caloric intake - typically by 20 - 40% of ad...

    Authors: John F Trepanowski, Robert E Canale, Kate E Marshall, Mohammad M Kabir and Richard J Bloomer
    Citation: Nutrition Journal 2011 10:107
  12. Tumor patients exhibit an increased peripheral demand of fatty acids and protein. Contrarily, tumors utilize glucose as their main source of energy supply. Thus, a diet supplying the cancer patient with suffic...

    Authors: Melanie Schmidt, Nadja Pfetzer, Micheal Schwab, Ingrid Strauss and Ulrike Kämmerer
    Citation: Nutrition & Metabolism 2011 8:54
  13. There is a well established link between obesity and cancer. Emerging research is characterising this relationship further and delineating the specific role of excess visceral adiposity, as opposed to simple o...

    Authors: Claire L Donohoe, Suzanne L Doyle and John V Reynolds
    Citation: Diabetology & Metabolic Syndrome 2011 3:12
  14. Diabetes mellitus has emerged as one of the main alarms to human health in the 21st century. Pronounced changes in the human environment, behavior and lifestyle have accompanied globalization, which resulted i...

    Authors: Edite Teixeira-Lemos, Sara Nunes, Frederico Teixeira and Flávio Reis
    Citation: Cardiovascular Diabetology 2011 10:12