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NK cells as the next option for cancer treatment

Edited by Dr Michael O'Dwyer

A thematic series in Stem Cell Research & Therapy

AdobeStock_269994642 © Sebastian Kaulitzki /

The thematic series focuses on NK cell based therapeutic approaches that are reasonably advanced in preclinical or clinical development and that could include adoptive NK cell transfer from different sources (e.g. NK cell lines, peripheral blood or cord derived NK cells, iPS derived NK cells), approaches to engineering of NK cells, including CAR's, cytokines, CD16, gene editing (e.g. CRISPR), NK cell engagers e.g. BiKEs and TriKEs, small molecules etc. 

  1. Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of immune surveillance. Given their ability to rapidly and effectively recognize and kill aberrant cells, especially tran...

    Authors: Gabrielle M. Robbins, Minjing Wang, Emily J. Pomeroy and Branden S. Moriarity
    Citation: Stem Cell Research & Therapy 2021 12:350
  2. The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti-tumor immune response in a wide...

    Authors: Margaret G. Lamb, Hemalatha G. Rangarajan, Brian P. Tullius and Dean A. Lee
    Citation: Stem Cell Research & Therapy 2021 12:211
  3. Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers. Current NK therapies usi...

    Authors: Keerthana Shankar, Christian M. Capitini and Krishanu Saha
    Citation: Stem Cell Research & Therapy 2020 11:234