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Neuroinflammation in the Retina

Edited by:
Professor Thomas Langmann, PhD, University of Cologne, Germany
Professor Przemyslaw (Mike) Sapieha, PhD, University of Montreal, Canada

Submission Status: Open   |   Submission Deadline: 31 July 2024

Journal of Neuroinflammation is calling for submissions to our new Collection on "Neuroinflammation in the Retina".

Image credit: Prof. Langmann

About the collection

Retinal degenerative and neovascular diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and rare monogenic dystrophies are major causes for global severe vision loss or blindness. In recent years, neuroinflammatory mechanisms have been identified as major factors for triggering the onset and progression of all these retinal diseases. Loss of retinal immune homeostasis is often accompanied by profound changes in cellular and humoral innate immunity and also involves adaptive immune responses by invading blood cell populations. We are only just beginning to understand the complex ocular inflammatory mechanisms and interplay between immune cells that occur in the eyes of patients with visual impairment.

This Collection seeks to discover novel immune mechanisms in the diseased retina that may offer novel diagnostic markers or highlight targets for immuno-modulatory therapies that could help to reduce the burden of vision loss worldwide.

As part of this Collection, we invite articles that cover the following topics:

• Role of resident and invading mononuclear phagocytes in the retina
• Role of T-cells and B-cells in retinal disease
• Complement factors in retinal disease
• Retinal pigment epithelium (RPE) inflammasome
• Immune responses in retinal gene therapy
• Microbiome and retinal immunity
• Retinal Immune memory and epigenetics
• Cellular senescence and retinal immune system
• Microglia-glia interactions in the retina

  1. Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein occlusions. Treatments for ischemic retinopathies fail to i...

    Authors: Rami A. Shahror, Esraa Shosha, Carol Morris, Melissa Wild, Shengyu Mu, Gabor Csanyi, Marjan Boerma, Nancy J. Rusch and Abdelrahman Y. Fouda
    Citation: Journal of Neuroinflammation 2024 21:170
  2. The eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural compartments such as the transparent vitreous body ensuring stability of ...

    Authors: Dennis-Dominik Rosmus, Jana Koch, Annika Hausmann, Aude Chiot, Franz Arnhold, Takahiro Masuda, Katrin Kierdorf, Stefanie Marie Hansen, Heidrun Kuhrt, Janine Fröba, Julian Wolf, Stefaniya Boneva, Martin Gericke, Bahareh Ajami, Marco Prinz, Clemens Lange…
    Citation: Journal of Neuroinflammation 2024 21:168
  3. The microglia-mediated neuroinflammation have been shown to play a crucial role in the ocular pathological angiogenesis process, but specific immunotherapies for neovascular ocular diseases are still lacking. ...

    Authors: Biyan Ni, Ziqi Yang, Tian Zhou, Hong Zhou, Yang Zhou, Shiya Lin, Huiyi Xu, Xiaojing Lin, Wei Yi, Chang He and Xialin Liu
    Citation: Journal of Neuroinflammation 2024 21:164
  4. Radiation retinopathy (RR) is a major side effect of ocular tumor treatment by plaque brachytherapy or proton beam therapy. RR manifests as delayed and progressive microvasculopathy, ischemia and macular edema...

    Authors: Cécile Lebon, Denis Malaise, Nicolas Rimbert, Manon Billet, Gabriel Ramasamy, Jérémie Villaret, Frédéric Pouzoulet, Alexandre Matet and Francine Behar-Cohen
    Citation: Journal of Neuroinflammation 2024 21:162
  5. Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell type-specific caspase-8 functions in cell death and inflammat...

    Authors: Xiangjun Yang, Qun Zeng, Maide Gözde İnam, Onur İnam, Chyuan-Sheng Lin and Gülgün Tezel
    Citation: Journal of Neuroinflammation 2024 21:145
  6. Autoimmune uveitis is a leading cause of severe vision loss, and animal models provide unique opportunities for studying its pathogenesis and therapeutic strategies. Here we employ scRNA-seq, RNA-seq and vario...

    Authors: Fa Yuan, Rong Zhang, Jiani Li, Qiannan Lei, Shuyi Wang, Fanying Jiang, Yanan Guo and Mengqing Xiang
    Citation: Journal of Neuroinflammation 2024 21:136
  7. The human gut microbiome (GM) is involved in inflammation and immune response regulation. Dysbiosis, an imbalance in this ecosystem, facilitates pathogenic invasion, disrupts immune equilibrium, and potentiall...

    Authors: Sophia C. Morandi, Elio L. Herzog, Marion Munk, Marco Kreuzer, Carlo R. Largiadèr, Sebastian Wolf, Martin Zinkernagel and Denise C. Zysset-Burri
    Citation: Journal of Neuroinflammation 2024 21:120
  8. NADPH oxidase (NOX), a primary source of endothelial reactive oxygen species (ROS), is considered a key event in disrupting the integrity of the blood-retinal barrier. Abnormalities in neurovascular-coupled im...

    Authors: Xin Shi, Panpan Li, Marc Herb, Hanhan Liu, Maoren Wang, Xiaosha Wang, Yuan Feng, Tim van Beers, Ning Xia, Huige Li and Verena Prokosch
    Citation: Journal of Neuroinflammation 2024 21:105
  9. Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subr...

    Authors: Dandan Liu, Jingxiao Du, Hai Xie, Haibin Tian, Lixia Lu, Chaoyang Zhang, Guo-Tong Xu and Jingfa Zhang
    Citation: Journal of Neuroinflammation 2024 21:75
  10. The retinal pigment epithelium (RPE) maintains photoreceptor viability and function, completes the visual cycle, and forms the outer blood-retinal barrier (oBRB). Loss of RPE function gives rise to several mon...

    Authors: Steven F. Abcouwer, Bruna Miglioranza Scavuzzi, Phillip E. Kish, Dejuan Kong, Sumathi Shanmugam, Xuan An Le, Jingyu Yao, Heather Hager and David N Zacks
    Citation: Journal of Neuroinflammation 2024 21:74
  11. Retinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte infiltration. Effective immune responses rely on coordinated actions of r...

    Authors: Federica M. Conedera, Despina Kokona, Martin S. Zinkernagel, Jens V. Stein, Charles P. Lin, Clemens Alt and Volker Enzmann
    Citation: Journal of Neuroinflammation 2024 21:68
  12. Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis by clearing cellular debris and regulating inflammation. These cells are activated in several blinding ischemic retin...

    Authors: Rami A. Shahror, Carol A. Morris, Aya A. Mohammed, Melissa Wild, Bushra Zaman, Christian D. Mitchell, Paul H. Phillips, Nancy J. Rusch, Esraa Shosha and Abdelrahman Y. Fouda
    Citation: Journal of Neuroinflammation 2024 21:65
  13. Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell ...

    Authors: Alice Brandli, Kirstan A. Vessey and Erica L. Fletcher
    Citation: Journal of Neuroinflammation 2024 21:64
  14. Inherited, age-related, and acute retinal diseases are often exacerbated by an aberrant or excessive activity of the complement system. Consequently, cells not directly affected by an acute event or genetic va...

    Authors: Josef Biber, Yassin Jabri, Sarah Glänzer, Aaron Dort, Patricia Hoffelner, Christoph Q. Schmidt, Oliver Bludau, Diana Pauly and Antje Grosche
    Citation: Journal of Neuroinflammation 2024 21:56
  15. Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical sig...

    Authors: Chong He, Kun Peng, Xiong Zhu, Zuo Wang, Wenbo Xiu, Gao Zhang, Yang Chen, Chaonan Sun, Xiao Xiao, Donghua Liu, An Li, Yanping Gao, Jinxia Wang, Ping Shuai, Yilian Chen, Ling Yu…
    Citation: Journal of Neuroinflammation 2024 21:43
  16. Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of blood components into retinal tissues, leading to activation of microglia, the resident phagocytes of the retina, promot...

    Authors: Derek Rodriguez, Kaira A. Church, Alicia N. Pietramale, Sandra M. Cardona, Difernando Vanegas, Colin Rorex, Micah C. Leary, Isabel A. Muzzio, Kevin R. Nash and Astrid E. Cardona
    Citation: Journal of Neuroinflammation 2024 21:42
  17. Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal neurovascular unit and play a critical role in DR. We therefore in...

    Authors: Anna M. Pfaller, Lew Kaplan, Madalena Carido, Felix Grassmann, Nundehui Díaz-Lezama, Farhad Ghaseminejad, Kirsten A. Wunderlich, Sarah Glänzer, Oliver Bludau, Thomas Pannicke, Bernhard H. F. Weber, Susanne F. Koch, Boyan Bonev, Stefanie M. Hauck and Antje Grosche
    Citation: Journal of Neuroinflammation 2024 21:33
  18. Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal space. The mononuclear phagocytes are composed of microglial ...

    Authors: Christophe Roubeix, Caroline Nous, Sébastien Augustin, Kaitryn E. Ronning, Thibaud Mathis, Frédéric Blond, Pauline Lagouge-Roussey, Sergio Crespo-Garcia, Patrick M. Sullivan, Emmanuel L. Gautier, Nadine Reichhart, José-Alain Sahel, Marie E. Burns, Michel Paques, Torben Lykke Sørensen, Olaf Strauss…
    Citation: Journal of Neuroinflammation 2024 21:22
  19. Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophage...

    Authors: Tianyi Shen, Ruoyi Lin, Chengyu Hu, Donghui Yu, Chengda Ren, Tingting Li, Meijiang Zhu, Zhongqi Wan, Tu Su, Yan Wu, Wenting Cai and Jing Yu
    Citation: Journal of Neuroinflammation 2023 20:308
  20. Neuroinflammation and mitochondrial dysfunction play crucial roles in retinal ischemia and reperfusion (IR) injury. Recent studies have identified mitochondrial function as a promising target for immunomodulat...

    Authors: Zhenlan Yang, Yidan Liu, Xuhao Chen, Shaofen Huang, Yangyang Li, Guitong Ye, Xu Cao, Wenru Su and Yehong Zhuo
    Citation: Journal of Neuroinflammation 2023 20:296
  21. Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascularization (CNV), and AMD is the leading cause of irreversible vision impairment in older ...

    Authors: Yu-Hsien Chang, Chung-Hsi Hsing, Chiao-Juno Chiu, Yi-Rou Wu, Sheng-Min Hsu and Yu-Hsiang Hsu
    Citation: Journal of Neuroinflammation 2023 20:279
  22. Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1−/− mice display alterations in non-classical monocytes and microgli...

    Authors: Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman and Jeremy A. Lavine
    Citation: Journal of Neuroinflammation 2023 20:238

Submission Guidelines

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This Collection welcomes submission of original Research Articles and Reviews. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Neuroinflammation in the Retina" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.