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New insights in pathogen-related cancers

Guest Editors: 
Marisa Gariglio: University of Piemonte Orientale, Novara-Italy
Mauro Pistello: University of Pisa, Italy 

New Content Item

Infectious Agents and Cancer is calling for submissions to our Collection on New insights in pathogen-related cancers. Infectious agents cause approximately 20% of all human cancer cases worldwide, with higher rates in low-income countries. Six human viruses, including high-risk alpha human papillomaviruses (HPV), hepatitis B (HBV) and C (HCV) viruses, human T-cell lymphotropic virus 1 (HTLV-1), Epstein–Barr virus (EBV), and Kaposi sarcoma-associated herpesvirus (HHV-8), have been classified as class 1 carcinogens by the International Agency for Research on Cancer. In addition, the Helicobacter pylori bacterium as well as the Opisthorchis viverrini, Clonorchis sinensis, and Schistosoma haematobium helminths have been also defined as class 1 carcinogens to humans. All known oncogenic pathogens can promote cell survival and transformation because of their common abilities to cause chronic insults, genetic and epigenetic alterations, deregulated metabolic pathways, and immune escape.

The global burden of pathogen-related cancers is expected to grow with the identification of novel oncogenic microorganisms or uncommon tropism of known agents in the body sites. Paradigmatic is the role of HPV infection in oropharyngeal cancers and the clinical relevance of such association. The cooperation of viruses with environmental risk factors, such as cutaneous HPV types and ultraviolet radiation or HBV and aflatoxin, is another important emerging issue in cancer development. Furthermore, recent findings showed the intriguing effects of microbiota in cancer susceptibility, neoplastic progression, co-infections with carcinogenic agents, and response to therapy.

This collection aims to gather and share novel information focusing on epidemiology, molecular biology, cellular biology, genetics, and epigenetics as well as translational research of infectious agents causing cancer. All types of manuscripts in this scope will be welcome, including research articles, brief reports, and review articles. 

Before submitting your manuscript, please ensure you have carefully read the submission guidelines. The complete manuscript should be submitted through the journal submission system. To ensure that you submit to the correct collection please select 'New insights in pathogen-related cancers' in the drop-down menu upon submission. 

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.

Image credit: Wire_man / stock.adobe.com


  1. Numerous studies have shown that Schistosoma japonicum infection correlates with an increased risk of liver hepatocellular carcinoma (LIHC). However, data regarding the role of this infection in LIHC oncogenesis ...

    Authors: Shuyan Sheng, Bangjie Chen, Ruiyao Xu, Yanxun Han, Deshen Mao, Yuerong Chen, Conghan Li, Wenzhuo Su, Xinyang Hu, Qing Zhao, Scott Lowe, Yuting Huang, Wei Shao and Yong Yao
    Citation: Infectious Agents and Cancer 2024 19:10
  2. The aim of this study was to determine the prevalence of Chlamydia trachomatis (CT) and Mycoplasma genitalium (MG) among HPV-positive women undergoing colposcopy at the Second Xiangya Hospital of Central South Un...

    Authors: Mengjie Jiang, Hui Ding, Ling He, Danning Xu, Ping Jiang, Haoneng Tang, Qian Wang, Xuemei Wang and Lingli Tang
    Citation: Infectious Agents and Cancer 2023 18:76
  3. Cancer, as a complex, heterogeneous disease, is currently affecting millions of people worldwide. Even if the most common traditional treatments, namely, chemotherapy (CTx) and radiotherapy (RTx), have been so...

    Authors: Iman Owliaee, Mehran khaledian, Armin Khaghani Boroujeni and Ali Shojaeian
    Citation: Infectious Agents and Cancer 2023 18:69
  4. Mutations in the NLRP3gene have previously been linked to certain forms of cancer, but there have not been any specific studies examining the association between NLRP3 polymorphisms and cervical cancer (CC). T...

    Authors: Qingchun Lu, Xiaoxia Lao, Jinghua Gan, Ping Du, Yingpei Zhou, Wenzheng Nong and Zhige Yang
    Citation: Infectious Agents and Cancer 2023 18:64
  5. Human papillomavirus (HPV) 16 and 18 cause approximately 70% of cervical cancer cases. The aim of this study was to evaluate whether co-infected with other HPV genotypes will affect the risk of cervical carcin...

    Authors: Mengyin Ao, Xiaoxi Yao, Danxi Zheng, Xuesai Gu and Mingrong Xi
    Citation: Infectious Agents and Cancer 2023 18:57
  6. The role of human parvovirus B19 (B19V) infection in malignant and benign lesions such as head and neck squamous cell carcinomas (HNSCCs) and oral mucocele lesions has not been established. Herein, we examined...

    Authors: Haniyeh Abuei, Sepide Namdari, Tahereh Pakdel, Fatemeh Pakdel, Azadeh Andishe-Tadbir, Abbas Behzad-Behbahani, Mohammad J. Ashraf, Parnian Alavi and Ali Farhadi
    Citation: Infectious Agents and Cancer 2023 18:51
  7. Colorectal cancer (CRC) is one of the most common cancers all over the world, and dysbiosis in the gut microbiota may play a role in colorectal carcinogenesis. Bacteroides fragilis can lead to tumorigenesis by ch...

    Authors: Leila Dadgar-Zankbar, Aref Shariati, Narjess Bostanghadiri, Zahra Elahi, Shiva Mirkalantari, Shabnam Razavi, Fatemeh Kamali and Davood Darban-Sarokhalil
    Citation: Infectious Agents and Cancer 2023 18:48
  8. Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. Despite numerous transcriptomics studies to understand its molecular basis, the impact ...

    Authors: Amal Alotaibi, Veerendra P. Gadekar, Pranav Swaroop Gundla, Sumana Mandarthi, Nidhi Jayendra, Asna Tungekar, B. V. Lavanya, Ashok Kumar Bhagavath, Mary Anne Wong Cordero, Janne Pitkaniemi, Shaik Kalimulla Niazi, Raghavendra Upadhya, Asmatanzeem Bepari and Prashantha Hebbar
    Citation: Infectious Agents and Cancer 2023 18:47
  9. Parasite infection is one of the many environmental factors that can significantly contribute to carcinogenesis and is already known to be associated with a variety of malignancies in both human and veterinary...

    Authors: Niccolò Fonti, Francesca Parisi, Francesca Mancianti, Giulia Freer and Alessandro Poli
    Citation: Infectious Agents and Cancer 2023 18:45
  10. We previously found that age, sex and malaria were associated with KSHV in individuals from Uganda. In this study, we have evaluated these same factors in relation to EBV in the same specimens. Overall, 74% (o...

    Authors: Angela Nalwoga, Vickie Marshall, Wendell Miley, Nazzarena Labo, Denise Whitby, Robert Newton and Rosemary Rochford
    Citation: Infectious Agents and Cancer 2023 18:38
  11. Primary seminal vesicle Burkitt lymphoma (PSBL) is rare that is not frequently reported. Burkitt lymphoma is often associated with extranodal organs. The diagnosis of carcinoma in seminal vesical can be diffic...

    Authors: Menghua Wu, Xin Zheng, Wei Wang, Jing Chang, Meng Xue, Yu Zhang, Jian Song and Jimao Zhao
    Citation: Infectious Agents and Cancer 2023 18:32