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Neuronal degeneration and regeneration

Neurons continue to hold out the most hope for a simple effective treatment to debilitating neuro-degenerative diseases. The plasticity of neurons and the (limited) natural regenerative capability of the brain suggests we just need to find the correct combination of cell types to unlock the repair of damaged brain tissues. Additionally, in vitro differentiated neurons are a powerful model for human diseases lacking an animal model and open new avenues for groundbreaking research into disease mechanisms in humans. This series, published in Cell Regeneration, aims to address those questions.

The articles in the series have undergone the journal’s standard peer-review process. The Editors for this series declare no competing interests.

  1. Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptio...

    Authors: Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang…
    Citation: Cell Regeneration 2015 4:12
  2. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has o...

    Authors: Zhijuan Mao, Suming Zhang and Hong Chen
    Citation: Cell Regeneration 2015 4:11