There is increasing evidence that non-coding RNAs play a major role in epigenetic regulation. This article collection focuses on understanding the mechanisms of non-coding RNA, describing insights into the biogenesis and activity of non-coding RNAs, their interaction with chromatin, and novel methods for analysis and manipulation of RNA-mediated regulation.
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quant...
Citation: Epigenetics & Chromatin 2014 7:8