The last few years have seen a wealth of knowledge on the role of epigenetic gene regulation in (patho-)physiological processes. New insights relate to the highly dynamic nature of epigenetic systems. Epigenetic regulatory proteins are in constant motion in the nucleus, exchanging between chromatin-bound and unbound states. In addition, various layers of chromatin folding show defined dynamics. The causal relationship between these dynamics of chromatin and nuclear organization with gene activity and silencing is still an open question of great importance. In this series, we aim to provide an overview of multiscale chromatin dynamics. In particular, we are interested in the following topics, but suggestions for alternative subjects are welcomed:
- Interpretation of single cell epigenetics and transcription dynamics
- The relationship between random epigenetic fluctuations and precise control of genome functioning
- Innovative, quantitative image-analysis tools to determine functional organization of epigenetics, chromatin, and nuclear organization
- Mimicking chromatin organization with artificial systems to simulate precise perturbations and simulation
- The role of chromatin and nuclear organization in aging and diseases
Keywords: multiscale chromatin organization; transcription dynamics; functional epigenomics; epigenetic networks; single cell epigenetics; epigenetic bioengineering; epigenetic models
Some articles in this collection have been sponsored by COST via payment of the article processing charge and this is indicated on the individual articles. All articles have undergone the journals’ standard peer-review processes. Please find out more about our journals and their policies (here for Clinical Epigenetics; here for Epigenetics Communications). Submission guidelines can be found here for Clinical Epigenetics/ here for Epigenetics Communications, and please submit to the series via our submission system (here for Clinical Epigenetics; here for Epigenetics Communications; there will be a field for which you can indicate if you are submitting to this series).