The tumor microenvironment (TME) has an effect on tumor development, growth, and resistance to therapy. Continuous interactions and exchanges between tumor cells and the TME are involved in angiogenesis, tumor genetic diversity, immune escape, and metastasis.
Developed and published by Molecular Cancer, this series aims to highlight significant findings and advances in our understanding of the role of the TME in cancer biology.
Neddylation: a novel modulator of the tumor microenvironment
Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis. The process of protein ne...