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Membrane and Protein Trafficking

Guest Editors:
Julian M. Carosi: 
South Australian Health and Medical Research Institute, Australia
Massimo Micaroni: University of Gothenburg, Sweden

BMC Molecular and Cell Biology has published this Collection on Membrane and Protein Trafficking. All eukaryotic cells rely on intracellular vesicle trafficking for the maintenance of membranes and organelles. In recognition of the importance of vesicular trafficking for cell function and its dysregulation in many disease states, BMC Molecular and Cell Biology has published this Collection on this topic.

Meet the Guest Editors

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Julian M. Carosi:  South Australian Health and Medical Research Institute, Australia

During his PhD, Dr Carosi studied how autophagy – a powerful cellular ‘waste disposal’ system – removes and destroys toxic proteins that accumulate in the brains of people with neurodegenerative diseases such as Alzheimer’s disease. Now as a postdoctoral researcher, Dr Carosi’s interests remain centred around autophagy, but with a deeper focus on understanding autophagy in molecular detail, investigating how stimuli activate or inhibit autophagy, and identifying ways to monitor this process in animals and humans.

Massimo Micaroni: University of Gothenburg, Sweden

Massimo Micaroni is a researcher at the Centre for Cellular Imaging Core Facility, University of Gothenburg. He was a Senior Staff scientist at the University of Queensland, Brisbane, Australia, working on the role of Rab6 secretory pathway and maintenance of the Golgi architecture. He moved to become a Staff Scientist at the University of Exeter, before becoming an Associate Professor in Cell Biology at Dalian University of Technology in China where his work focused on the role of the Golgi calcium pump. He joined the University of Gothenburg in 2016 where he is responsible for the electron microscopy facility.

About the collection

BMC Molecular and Cell Biology has published this Collection on Membrane and Protein Trafficking. In Eukaryotic cells, intracellular vesicle trafficking is crucial for the maintenance of membranes and organelles. Originating from the Endoplasmic Reticulum and Golgi system, vesicles transport cargo - macromolecules, proteins and lipids - to various organelles, as well as the extracellular space through exocytosis. Furthermore, formation of vesicles via endocytosis plays a key role in recycling of plasma membrane proteins and lipids through the endolysomal pathway. These processes must be carefully orchestrated from vesicle formation to transportation along the cytoskeletal network and fusion with the target membrane. Dysregulation of these processes have been in many human diseases from neurodegenerative diseases to cancer to rare-inherited diseases. 

In recognition of the importance of these processes BMC Molecular and Cell Biology has published this Collection on the following topics:

  • Regulation of the endolysomal pathway and its dysfunction in disease
  • Endoplasmic Reticulum and golgi organization and biology
  • Role and regulation of membrane contacts for communication and lipid transport
  • Microtubule dynamics and ATP-dependent motor proteins for vesicle transport
  • Vesicle formation and fusion
  • Structure and function of vesicle coating proteins in endocytosis 
  • Cargo recognition and loading
  • Role of membrane lipid composition in vesicle biology
  • Autophagy and selective autophagy
  • Secretory autophagy
  • Role of extracellular vesicles in health and cancer tissues

Image credit: Christoph Burgstedt / Getty

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of Research Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, SNAPP. During the submission process you will be asked whether you are submitting to a Collection, please select "Membrane and Protein Trafficking" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.