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Microbiome in human physiological function

Eric Erbe, digital colorization by Christopher Pooley, both of USDAGuest Editor: Dr Santanu Banerjee, University of Miami, Florida, USA

The association of microbes with humans and their role in influencing host physiology has been common knowledge since the early nineteenth century. With the recent advent of 16s pyrosequencing and whole-genome sequence-based molecular phylogeny, we are gradually understanding the mechanisms by which microbial perturbations in various mucosal surfaces influence host physiology in health and disease. In this series, we aim to address questions on mechanisms operating in microbial cells which make important contribution to effects on microbes on human physiology. 

  1. Extracellular metabolites of short chain fatty acids (SCFA) excreted by gut microbiota have been reported to play an important role in the regulation of intestinal homeostasis. Apart from supplying energy, SCF...

    Authors: Atchareeya Nakkarach, Hooi Ling Foo, Adelene Ai-Lian Song, Nur Elina Abdul Mutalib, Sunee Nitisinprasert and Ulaiwan Withayagiat

    Citation: Microbial Cell Factories 2021 20:36

    Content type: Research

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  2. Exocrine pancreatic insufficiency (EPI) is characterized by the loss of active pancreatic enzymes and a resulting severely reduced food digestion. EPI therapy requires orally applied pancreatic enzyme replacem...

    Authors: Sabrina Ritz, Daniela Hahn, Haleluya T. Wami, Karin Tegelkamp, Ulrich Dobrindt and Juergen Schnekenburger

    Citation: Microbial Cell Factories 2020 19:221

    Content type: Research

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  3. Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the development of colorectal cancer (CRC). However, the c...

    Authors: Fang Yang, Jennifer A. A. DeLuca, Rani Menon, Erika Garcia-Vilarato, Evelyn Callaway, Kerstin K. Landrock, Kyongbum Lee, Stephen H. Safe, Robert S. Chapkin, Clinton D. Allred and Arul Jayaraman

    Citation: Microbial Cell Factories 2020 19:219

    Content type: Research

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  4. All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and v...

    Authors: Taha Baghbani, Hossein Nikzad, Javid Azadbakht, Fatemeh Izadpanah and Hamed Haddad Kashani

    Citation: Microbial Cell Factories 2020 19:217

    Content type: Review

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  5. T helper (Th)17 and regulatory T (Treg) cells with toll-like receptor (TLR)-2 have been acknowledged to play a critical role in chronic rhinosinusitis with nasal polyposis (CRSwNP). However, its pathogenesis h...

    Authors: Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Sajad Ahmad Dar, Shafiul Haque, Neelima Gupta, Sonal Sharma, Vishnampettai Ganapathysubramanian Ramachandran, Sanskriti Sharma, Charu Jain and Shipra Sharma

    Citation: Microbial Cell Factories 2020 19:215

    Content type: Research

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  6. Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this inc...

    Authors: Wallace Jeng Yang Chee, Shu Yih Chew and Leslie Thian Lung Than

    Citation: Microbial Cell Factories 2020 19:203

    Content type: Review

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  7. Probiotics have several health benefits by modulating gut microbiome; however, techno-functional limitations such as viability controls have hampered their full potential applications in the food and pharmaceu...

    Authors: Basavaprabhu H. Nataraj, Syed Azmal Ali, Pradip V. Behare and Hariom Yadav

    Citation: Microbial Cell Factories 2020 19:168

    Content type: Review

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  8. Obesity is a major problem worldwide and severely affects public safety. As a metabolite of gut microbiota, endogenous butyric acid participates in energy and material metabolism. Considering the serious side ...

    Authors: Liang Bai, Mengxue Gao, Xiaoming Cheng, Guangbo Kang, Xiaocang Cao and He Huang

    Citation: Microbial Cell Factories 2020 19:94

    Content type: Research

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  9. Autoimmune diseases have been associated with changes in the gut microbiome. In this study, the gut microbiome was evaluated in individuals with dry eye and bacterial compositions were correlated to dry eye (D...

    Authors: Roberto Mendez, Arjun Watane, Monika Farhangi, Kara M. Cavuoto, Tom Leith, Shrish Budree, Anat Galor and Santanu Banerjee

    Citation: Microbial Cell Factories 2020 19:90

    Content type: Research

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  10. Resistance to therapy is one of the major factors that contribute to dismal survival statistics in pancreatic cancer. While there are many tumor intrinsic and tumor microenvironment driven factors that contrib...

    Authors: Kousik Kesh, Roberto Mendez, Leila Abdelrahman, Santanu Banerjee and Sulagna Banerjee

    Citation: Microbial Cell Factories 2020 19:75

    Content type: Research

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  11. In the last decade, increasing evidence has shown that changes in human gut microbiota are associated with diseases, such as obesity. The excreted/secreted proteins (secretome) of the gut microbiota affect the...

    Authors: Luigui Gallardo-Becerra, Fernanda Cornejo-Granados, Rodrigo García-López, Alejandra Valdez-Lara, Shirley Bikel, Samuel Canizales-Quinteros, Blanca E. López-Contreras, Alfredo Mendoza-Vargas, Henrik Nielsen and Adrián Ochoa-Leyva

    Citation: Microbial Cell Factories 2020 19:61

    Content type: Research

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  12. The gut microbiota that inhabit our gastrointestinal tract are well known to play an important role in maintaining human health in many aspects, including facilitating the digestion and absorption of nutrients...

    Authors: Zhao Zhou, Xin Chen, Huakang Sheng, Xiaolin Shen, Xinxiao Sun, Yajun Yan, Jia Wang and Qipeng Yuan

    Citation: Microbial Cell Factories 2020 19:56

    Content type: Review

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  13. Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, and in an effort to identify novel therapeutic target for this disease in recent years, human microbiota has attracted much inte...

    Authors: Liang Shen

    Citation: Microbial Cell Factories 2020 19:50

    Content type: Review

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  14. Spore-forming bacteria of the Bacillus genus are widely used probiotics known to exert their beneficial effects also through the stimulation of the host immune response. The oral delivery of B. toyonensis spores ...

    Authors: Francisco Denis S. Santos, Arianna Mazzoli, Ana Raquel Maia, Anella Saggese, Rachele Isticato, Fabio Leite, Susanna Iossa, Ezio Ricca and Loredana Baccigalupi

    Citation: Microbial Cell Factories 2020 19:42

    Content type: Research

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  15. The gut microbiota can significantly affect the function of the intestinal barrier. Some intestinal probiotics (such as Lactobacillus, Bifidobacteria, a few Escherichia coli strains, and a new generation of probi...

    Authors: Qing Liu, Zhiming Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai and Wei Chen

    Citation: Microbial Cell Factories 2020 19:23

    Content type: Review

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