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Microbiome in human physiological function

Eric Erbe, digital colorization by Christopher Pooley, both of USDAGuest Editor: Dr Santanu Banerjee, University of Miami, Florida, USA

The association of microbes with humans and their role in influencing host physiology has been common knowledge since the early nineteenth century. With the recent advent of 16s pyrosequencing and whole-genome sequence-based molecular phylogeny, we are gradually understanding the mechanisms by which microbial perturbations in various mucosal surfaces influence host physiology in health and disease. In this series, we aim to address questions on mechanisms operating in microbial cells which make important contribution to effects on microbes on human physiology. 

  1. Faecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridium difficile infections and chronic gastrointestional infections. However, the risks of FMT and the selection process of suit...

    Authors: Jianquan He, Xingxiang He, Yonghui Ma, Luxi Yang, Haiming Fang, Shu Shang, Huping Xia, Guanghui Lian, Hailing Tang, Qizhi Wang, Junping Wang, Zhihui Lin, Jianbo Wen, Yuedong Liu, Chunbao Zhai, Wen Wang…
    Citation: Microbial Cell Factories 2021 20:216
    Content type: Research Published on:

  2. Parkinson’s disease (PD) is a neurodegenerative disorder and 70–80% of PD patients suffer from gastrointestinal dysfunction such as constipation. We aimed to assess the efficacy and safety of fecal microbiota ...

    Authors: Xiao-yi Kuai, Xiao-han Yao, Li-juan Xu, Yu-qing Zhou, Li-ping Zhang, Yi Liu, Shao-fang Pei and Chun-li Zhou
    Citation: Microbial Cell Factories 2021 20:98
    Content type: Research Published on:

  3. Extracellular metabolites of short chain fatty acids (SCFA) excreted by gut microbiota have been reported to play an important role in the regulation of intestinal homeostasis. Apart from supplying energy, SCF...

    Authors: Atchareeya Nakkarach, Hooi Ling Foo, Adelene Ai-Lian Song, Nur Elina Abdul Mutalib, Sunee Nitisinprasert and Ulaiwan Withayagiat
    Citation: Microbial Cell Factories 2021 20:36
    Content type: Research Published on:

  4. Exocrine pancreatic insufficiency (EPI) is characterized by the loss of active pancreatic enzymes and a resulting severely reduced food digestion. EPI therapy requires orally applied pancreatic enzyme replacem...

    Authors: Sabrina Ritz, Daniela Hahn, Haleluya T. Wami, Karin Tegelkamp, Ulrich Dobrindt and Juergen Schnekenburger
    Citation: Microbial Cell Factories 2020 19:221
    Content type: Research Published on:

  5. Diet, loss of aryl hydrocarbon receptor (AhR) expression and their modification of the gut microbiota community composition and its metabolites affect the development of colorectal cancer (CRC). However, the c...

    Authors: Fang Yang, Jennifer A. A. DeLuca, Rani Menon, Erika Garcia-Vilarato, Evelyn Callaway, Kerstin K. Landrock, Kyongbum Lee, Stephen H. Safe, Robert S. Chapkin, Clinton D. Allred and Arul Jayaraman
    Citation: Microbial Cell Factories 2020 19:219
    Content type: Research Published on:

  6. All of humans and other mammalian species are colonized by some types of microorganisms such as bacteria, archaea, unicellular eukaryotes like fungi and protozoa, multicellular eukaryotes like helminths, and v...

    Authors: Taha Baghbani, Hossein Nikzad, Javid Azadbakht, Fatemeh Izadpanah and Hamed Haddad Kashani
    Citation: Microbial Cell Factories 2020 19:217
    Content type: Review Published on:

  7. T helper (Th)17 and regulatory T (Treg) cells with toll-like receptor (TLR)-2 have been acknowledged to play a critical role in chronic rhinosinusitis with nasal polyposis (CRSwNP). However, its pathogenesis h...

    Authors: Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Sajad Ahmad Dar, Shafiul Haque, Neelima Gupta, Sonal Sharma, Vishnampettai Ganapathysubramanian Ramachandran, Sanskriti Sharma, Charu Jain and Shipra Sharma
    Citation: Microbial Cell Factories 2020 19:215
    Content type: Research Published on:

  8. Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this inc...

    Authors: Wallace Jeng Yang Chee, Shu Yih Chew and Leslie Thian Lung Than
    Citation: Microbial Cell Factories 2020 19:203
    Content type: Review Published on:

  9. Probiotics have several health benefits by modulating gut microbiome; however, techno-functional limitations such as viability controls have hampered their full potential applications in the food and pharmaceu...

    Authors: Basavaprabhu H. Nataraj, Syed Azmal Ali, Pradip V. Behare and Hariom Yadav
    Citation: Microbial Cell Factories 2020 19:168
    Content type: Review Published on:

  10. Obesity is a major problem worldwide and severely affects public safety. As a metabolite of gut microbiota, endogenous butyric acid participates in energy and material metabolism. Considering the serious side ...

    Authors: Liang Bai, Mengxue Gao, Xiaoming Cheng, Guangbo Kang, Xiaocang Cao and He Huang
    Citation: Microbial Cell Factories 2020 19:94
    Content type: Research Published on:

  11. Autoimmune diseases have been associated with changes in the gut microbiome. In this study, the gut microbiome was evaluated in individuals with dry eye and bacterial compositions were correlated to dry eye (D...

    Authors: Roberto Mendez, Arjun Watane, Monika Farhangi, Kara M. Cavuoto, Tom Leith, Shrish Budree, Anat Galor and Santanu Banerjee
    Citation: Microbial Cell Factories 2020 19:90
    Content type: Research Published on:

  12. Resistance to therapy is one of the major factors that contribute to dismal survival statistics in pancreatic cancer. While there are many tumor intrinsic and tumor microenvironment driven factors that contrib...

    Authors: Kousik Kesh, Roberto Mendez, Leila Abdelrahman, Santanu Banerjee and Sulagna Banerjee
    Citation: Microbial Cell Factories 2020 19:75
    Content type: Research Published on:

  13. In the last decade, increasing evidence has shown that changes in human gut microbiota are associated with diseases, such as obesity. The excreted/secreted proteins (secretome) of the gut microbiota affect the...

    Authors: Luigui Gallardo-Becerra, Fernanda Cornejo-Granados, Rodrigo García-López, Alejandra Valdez-Lara, Shirley Bikel, Samuel Canizales-Quinteros, Blanca E. López-Contreras, Alfredo Mendoza-Vargas, Henrik Nielsen and Adrián Ochoa-Leyva
    Citation: Microbial Cell Factories 2020 19:61
    Content type: Research Published on:

  14. The gut microbiota that inhabit our gastrointestinal tract are well known to play an important role in maintaining human health in many aspects, including facilitating the digestion and absorption of nutrients...

    Authors: Zhao Zhou, Xin Chen, Huakang Sheng, Xiaolin Shen, Xinxiao Sun, Yajun Yan, Jia Wang and Qipeng Yuan
    Citation: Microbial Cell Factories 2020 19:56
    Content type: Review Published on:

  16. Spore-forming bacteria of the Bacillus genus are widely used probiotics known to exert their beneficial effects also through the stimulation of the host immune response. The oral delivery of B. toyonensis spores ...

    Authors: Francisco Denis S. Santos, Arianna Mazzoli, Ana Raquel Maia, Anella Saggese, Rachele Isticato, Fabio Leite, Susanna Iossa, Ezio Ricca and Loredana Baccigalupi
    Citation: Microbial Cell Factories 2020 19:42
    Content type: Research Published on:

  17. The gut microbiota can significantly affect the function of the intestinal barrier. Some intestinal probiotics (such as Lactobacillus, Bifidobacteria, a few Escherichia coli strains, and a new generation of probi...

    Authors: Qing Liu, Zhiming Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Qixiao Zhai and Wei Chen
    Citation: Microbial Cell Factories 2020 19:23
    Content type: Review Published on: