Skip to main content

Metabolic regulation of lipids and fatty acids and risk of cardiometabolic disease

Edited by Vibeke Telle-Hansen

New Content ItemLipids in Health and Disease invites you to contribute a manuscript to our new thematic series, “Metabolic regulation of lipids and fatty acids and risk of cardiometabolic disease”.

Our everyday food choices have a major impact on health, by either increasing or decreasing the risk of disease. Lipids and fatty acids are well known to play an important part in metabolic regulation, including the risk of cardiometabolic disease. Diet is also one of the most important modulators of gut microbiota composition, in which the short chain fatty acids derived from bacterial fermentation in the gut have been suggested to impact the host’s lipid metabolism. However, there is a lack of mechanistic insights into their impact on lipid metabolism and metabolic regulation.

Interindividual differences in the response to environmental stimuli, including the diet, metabolic regulation and risk profiles is a focus area within the field of molecular nutrition, aiming at a personalized nutrition or precision nutrition approach to prevention and treatment of diet-related diseases. To succeed with precision nutrition, a more profound description of the metabolic regulatory mechanisms of lipids and fatty acids, including interindividual differences, is necessary to enhance our understanding of the development of cardiometabolic disease, and how to prevent it.

This Special Issue aims to include original research and up-to-date reviews on individual regulation of lipids and fatty acids, in relation to different risk profiles (metabotypes) of cardiometabolic disease.

Fatty acids, lipids, metabolic regulation, gut microbiota, gut microbiota metabolites, metabotypes, cardiometabolic disease


  • Individual response to dietary fat, and the effect on lipid metabolism and cardiometabolic regulation

  • Dietary fat and regulation of gut microbiota

  • Individual gut microbiota signature, effect on lipid metabolism and cardiometabolic regulation

  • Microbiota derived metabolites, lipid metabolism and cardiometabolic regulation

Questions to be answered:

  • What are the individual differences in the response to fatty acids and lipids?
  • Do dietary fatty acids and lipids affect the gut microbiota, and are there individual differences?
  • What is the mechanistic link between gut microbiota and the hosts’ lipid metabolism?
  • How do short chain fatty acids (SCFA) affect metabolic regulation, including gene transcription?
  • How do microbial lipids alter intestinal and circulating lipid concentrations, and thereby impact metabolic regulation of the host?

All submissions should be made by June 30th, 2022.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).

  1. Non-high-density lipoprotein cholesterol (non-HDL-C) may be an independent risk factor for cardio-cerebrovascular disease (CVD); however, the cutoff level in patients on maintenance hemodialysis (MHD) is unknown.

    Authors: Denggui Luo, Yueming Luo, Yanhong Zou, Yuanzhao Xu, Bo Fu, Dong Yang, Jun Yang, Cai Xu, Shuyi Ling, Shunmin Li and Airong Qi
    Citation: Lipids in Health and Disease 2021 20:159
  2. Acylcarnitine is an intermediate product of fatty acid oxidation. It is reported to be closely associated with the occurrence of diabetic cardiomyopathy (DCM). However, the mechanism of acylcarnitine affecting...

    Authors: Dan-meng Zheng, Zhen-ni An, Ming-hao Ge, Dong-zhuo Wei, Ding-wen Jiang, Xue-jiao Xing, Xiao-lei Shen and Chang Liu
    Citation: Lipids in Health and Disease 2021 20:151
  3. Dyslipidemia is a feature of impaired metabolic health in conjunction with impaired glucose metabolism and central obesity. However, the contribution of factors to postprandial lipemia in healthy but metabolic...

    Authors: Stephanie M. Wilson, Adam P. Maes, Carl J. Yeoman, Seth T. Walk and Mary P. Miles
    Citation: Lipids in Health and Disease 2021 20:107
  4. The deleterious effect of maternal high-fat diet (HFD) on the fetal rat liver may cause later development of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the effect of mater...

    Authors: Szu-Wei Huang, Yu-Che Ou, Kuo-Shu Tang, Hong-Ren Yu, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Jiunn-Ming Sheen, Chih-Yao Hou, Ching-Chou Tsai and Mao-Meng Tiao
    Citation: Lipids in Health and Disease 2021 20:100