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The impact of acute and chronic medical disorders on accelerated cognitive decline

Edited by Carol Brayne and Daniel Davis

It is increasingly recognised that cognitive decline can be precipitated by acute events, such as delirium, surgery or intensive care unit admission. Moreover, cognitive impairment is observed in connection with many chronic systemic disorders, such as heart failure and diabetes. This special series, published in Alzheimer's Research & Therapy, explores how acute and chronic systemic illness might lead to permanent decrements in cognition, and addresses how processes outside the brain might interact, influence and affect the pathophysiology of cognitive decline and dementia.

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Series Editors, with final decisions made by the Editors-in-Chief. The Series Editors and Editors-in-Chief declare no competing interests.

  1. Review

    Frailty and the risk of cognitive impairment

    Aging occurs as a series of small steps, first causing cellular damage and then affecting tissues and organs. This is also true in the brain. Frailty, a state of increased risk due to accelerated deficit accum...

    Samuel D. Searle and Kenneth Rockwood

    Alzheimer's Research & Therapy 2015 7:54

    Published on: 3 August 2015

  2. Review

    Lung disease as a determinant of cognitive decline and dementia

    Almost 40 million people currently live with dementia but this is estimated to double over the next 20 years; despite this, research identifying modifiable risk factors is scarce. There is increasing evidence ...

    James W Dodd

    Alzheimer's Research & Therapy 2015 7:32

    Published on: 21 March 2015

  3. Review

    Kidney disease as a determinant of cognitive decline and dementia

    Chronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of tradit...

    Thorleif Etgen

    Alzheimer's Research & Therapy 2015 7:29

    Published on: 17 March 2015