Skip to main content

All Reviews Collection

Mobile DNA homepage

Repository for all published Review articles. Contributions from some of the leading researchers working with mobile DNA.

  2. Transposable elements (TEs) are major components of all vertebrate genomes that can cause deleterious insertions and genomic instability. However, depending on the specific genomic context of their insertion s...

    Authors: Ema Etchegaray, Magali Naville, Jean-Nicolas Volff and Zofia Haftek-Terreau
    Citation: Mobile DNA 2021 12:1
    Content type: Review Published on:

  3. Insertion sequences (IS) are ubiquitous transposable elements with a very simple organization: two inverted repeats flanking a transposase coding gene. IS982 is one of 26 insertion sequence families known so far....

    Authors: Nancy Fayad, Mireille Kallassy Awad and Jacques Mahillon
    Citation: Mobile DNA 2020 11:24
    Content type: Review Published on:

  5. Transposable elements in prokaryotes are found in many forms and therefore a robust nomenclature system is needed in order to allow researchers to describe and search for them in publications and databases. He...

    Authors: Supathep Tansirichaiya, Md. Ajijur Rahman and Adam P. Roberts
    Citation: Mobile DNA 2019 10:40
    Content type: Review Published on:

  7. Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape i...

    Authors: Liane Gagnier, Victoria P. Belancio and Dixie L. Mager
    Citation: Mobile DNA 2019 10:15
    Content type: Review Published on:

  8. Human stem cells harbor significant potential for basic and clinical translational research as well as regenerative medicine. Currently ~ 3000 adult and ~ 30 pluripotent stem cell-based, interventional clinica...

    Authors: Gerald G. Schumann, Nina V. Fuchs, Pablo Tristán-Ramos, Attila Sebe, Zoltán Ivics and Sara R. Heras
    Citation: Mobile DNA 2019 10:9
    Content type: Review Published on:

  9. Retrotransposons are transposable elements (TEs) capable of “jumping” in germ, embryonic and tumor cells and, as is now clearly established, in the neuronal lineage. Mosaic TE insertions form part of a broader...

    Authors: Geoffrey J. Faulkner and Victor Billon
    Citation: Mobile DNA 2018 9:22
    Content type: Review Published on:

  15. Cancer arises from a series of genetic and epigenetic changes, which result in abnormal expression or mutational activation of oncogenes, as well as suppression/inactivation of tumor suppressor genes. Aberrant...

    Authors: Artem Babaian and Dixie L. Mager
    Citation: Mobile DNA 2016 7:24
    Content type: Review Published on:

  16. Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on the non-long terminal repeat ret...

    Authors: John L. Goodier
    Citation: Mobile DNA 2016 7:16
    Content type: Review Published on:

  17. Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of transposable elements (TE) such as retrotransposons. On a shorter time scale it has been established that new TE in...

    Authors: Dustin C. Hancks and Haig H. Kazazian Jr.
    Citation: Mobile DNA 2016 7:9
    Content type: Review Published on:

  19. Tandem C2H2-type zinc finger proteins (ZFPs) constitute the largest transcription factor family in animals. Tandem-ZFPs bind DNA in a sequence-specific manner through arrays of multiple zinc finger domains tha...

    Authors: Gernot Wolf, David Greenberg and Todd S. Macfarlan
    Citation: Mobile DNA 2015 6:17
    Content type: Review Published on:

  20. Present in the genomes of bacteria and eukaryotic organelles, group II introns are an ancient class of ribozymes and retroelements that are believed to have been the ancestors of nuclear pre-mRNA introns. Desp...

    Authors: Steven Zimmerly and Cameron Semper
    Citation: Mobile DNA 2015 6:7
    Content type: Review Published on:

  21. Transposable elements (TEs) are major components of genomes. Their mobilization may affect genomic expression and be a threat to genetic stability. This is why they have to be tightly regulated by a dedicated ...

    Authors: Emmanuelle Théron, Cynthia Dennis, Emilie Brasset and Chantal Vaury
    Citation: Mobile DNA 2014 5:28
    Content type: Review Published on:

  23. Transposable elements (TEs) are major structural components of eukaryotic genomes; however, mobilization of TEs generally has negative effects on the host genome. To counteract this threat, host cells have evo...

    Authors: Soichiro Yamanaka, Mikiko C Siomi and Haruhiko Siomi
    Citation: Mobile DNA 2014 5:22
    Content type: Review Published on:

  24. Processed pseudogenes are copies of messenger RNAs that have been reverse transcribed into DNA and inserted into the genome using the enzymatic activities of active L1 elements. Processed pseudogenes generally...

    Authors: Haig H Kazazian Jr
    Citation: Mobile DNA 2014 5:20
    Content type: Commentary Published on:

  26. LINE-1s (L1s), the only currently active autonomous mobile DNA in humans, occupy at least 17% of human DNA. Throughout evolution, the L1 has also been responsible for genomic insertion of thousands of processe...

    Authors: John L Goodier
    Citation: Mobile DNA 2014 5:11
    Content type: Commentary Published on:

  27. Group I introns are intervening sequences that have invaded tRNA, rRNA and protein coding genes in bacteria and their phages. The ability of group I introns to self-splice from their host transcripts, by actin...

    Authors: Georg Hausner, Mohamed Hafez and David R Edgell
    Citation: Mobile DNA 2014 5:8
    Content type: Review Published on:

  30. Mobile group II introns are bacterial retrotransposons that combine the activities of an autocatalytic intron RNA (a ribozyme) and an intron-encoded reverse transcriptase to insert site-specifically into DNA. ...

    Authors: Peter J Enyeart, Georg Mohr, Andrew D Ellington and Alan M Lambowitz
    Citation: Mobile DNA 2014 5:2
    Content type: Review Published on:

  31. Group I introns are a distinct class of RNA self-splicing introns with an ancient origin. All known group I introns present in eukaryote nuclei interrupt functional ribosomal RNA genes located in ribosomal DNA...

    Authors: Annica Hedberg and Steinar D Johansen
    Citation: Mobile DNA 2013 4:17
    Content type: Review Published on:

  36. The centromeric and pericentromeric regions of plant chromosomes are colonized by Ty3/gypsy retrotransposons, which, on the basis of their reverse transcriptase sequences, form the chromovirus CRM clade. Despi...

    Authors: Pavel Neumann, Alice Navrátilová, Andrea Koblížková, Eduard Kejnovský, Eva Hřibová, Roman Hobza, Alex Widmer, Jaroslav Doležel and Jiří Macas
    Citation: Mobile DNA 2011 2:4
    Content type: Research Published on:

  40. Scientific history has had a profound effect on the theories of evolution. At the beginning of the 21st century, molecular cell biology has revealed a dense structure of information-processing networks that us...

    Authors: James A Shapiro
    Citation: Mobile DNA 2010 1:4
    Content type: Review Published on: