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Anti-malaria drug efficacy and resistance

malaria treatment © jarun011 / stock.adobe.com

Artemisinin-based combination therapies (ACTs) has been adopted as first-line treatments for uncomplicated Plasmodium falciparum malaria as an integral part of the recent success in global malaria control. Between 2010 and 2017, an estimated 2.74 billion treatment courses of ACTs was delivered. However, the efficacy of ACTs is endangered by the emergence of resistance to artemisinin and partner drug which becomes a major threat to malaria elimination. We are delighted to present a cross-journal series to highlight the studies on efficiency of ACTs and implications of antimalarial drug resistance.

  1. The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination ther...

    Authors: Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke I. Ayede, Chimere Agomo, Onikepe A. Folarin, Grace O. Gbotosho, Christian Happi, Stephen Oguche, Henrietta U. Okafor, Martin Meremikwu, Philip Agomo, William Ogala, Ismaila Watila, Olugbenga Mokuolu…
    Citation: Infectious Diseases of Poverty 2019 8:69
    Content type: Research Article Published on:

  2. In acute falciparum malaria, asexual parasite reduction ratio two days post-treatment initiation (PRRD2) ≥ 10 000 per cycle has been used as a measure of the rapid clearance of parasitaemia and efficacy of art...

    Authors: Kazeem Akano, Godwin Ntadom, Chimere Agomo, Christian T. Happi, Onikepe A. Folarin, Grace O. Gbotosho, Olugbenga Mokuolu, Finomo Finomo, Joy C. Ebenebe, Nma Jiya, Jose Ambe, Robinson Wammanda, George Emechebe, Oluwabunmi K. Basorun, Olubunmi A. Wewe, Sikiru Amoo…
    Citation: Infectious Diseases of Poverty 2018 7:122
    Content type: Research Article Published on:

  3. As Ethiopia is one of the sub-Saharan countries with a great burden of malaria the effectiveness of first line anti-malarial drugs is the major concern. The aim of this study was to synthesize the available ev...

    Authors: Mohammed Biset Ayalew
    Citation: Infectious Diseases of Poverty 2017 6:157
    Content type: Scoping Review Published on:

  4. Drug resistance is one of the greatest challenges of malaria control programmes, with the monitoring of parasite resistance to artemisinins or to Artemisinin Combination Therapy (ACT) partner drugs critical to...

    Authors: Tobias O. Apinjoh, Regina N. Mugri, Olivo Miotto, Hanesh F. Chi, Rolland B. Tata, Judith K. Anchang-Kimbi, Eleanor M. Fon, Delphine A. Tangoh, Robert V. Nyingchu, Christopher Jacob, Roberto Amato, Abdoulaye Djimde, Dominic Kwiatkowski, Eric A. Achidi and Alfred Amambua-Ngwa
    Citation: Infectious Diseases of Poverty 2017 6:136
    Content type: Research Article Published on:

  5. This study examined evolving malaria profiles from January, 2010 to December, 2014 to evaluate achievements and challenges of implementing measures to prevent and control spread of artemisinin resistance in My...

    Authors: Thet Wai Nwe, Tin Oo, Khin Thet Wai, Shuisen Zhou, Johan van Griensven, Palanivel Chinnakali, Safieh Shah and Aung Thi
    Citation: Infectious Diseases of Poverty 2017 6:76
    Content type: Research Article Published on:

  6. Malaria is a major cause of morbidity and mortality in many African countries and parts of Asia and South America. Novel approaches to combating the disease have emerged in recent years and several drug candid...

    Authors: Akshaya Srikanth Bhagavathula, Asim Ahmed Elnour and Abdulla Shehab
    Citation: Infectious Diseases of Poverty 2016 5:103
    Content type: Scoping Review Published on: