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Systemic lupus erythematosus

Written by renowned experts in the field, this collection of review articles provides an in-depth discussion of recent developments in the genetic background, pathogenesis and treatment of systemic lupus erythematosus. An unrestricted educational grant from UCB has enabled BioMed Central to make this series free to access online. UCB has had no input into the content of the series or the articles themselves. All published articles have been independently prepared by the authors, and have been subject to the journal’s standard peer review process.

  1. Review

    The genetics of lupus: a functional perspective

    Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and is characterized by chronic inflammation and the production of anti-nuclear auto-antibodies. In the era of genome...

    Sandra G Guerra, Timothy J Vyse and Deborah S Cunninghame Graham

    Arthritis Research & Therapy 2012 14:211

    Published on: 29 May 2012

  2. Review

    Mechanisms of tissue injury in lupus nephritis

    Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammatio...

    Tamara K Nowling and Gary S Gilkeson

    Arthritis Research & Therapy 2011 13:250

    Published on: 21 December 2011

  3. Review

    Mechanisms of B cell autoimmunity in SLE

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclea...

    Thomas Dörner, Claudia Giesecke and Peter E Lipsky

    Arthritis Research & Therapy 2011 13:243

    Published on: 27 October 2011

  4. Review

    Cytokine disturbances in systemic lupus erythematosus

    The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their protein and gene expression profile...

    Noam Jacob and William Stohl

    Arthritis Research & Therapy 2011 13:228

    Published on: 6 July 2011

  5. Review

    Chromatin as a target antigen in human and murine lupus nephritis

    The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-react...

    Annica Hedberg, Elin S Mortensen and Ole P Rekvig

    Arthritis Research & Therapy 2011 13:214

    Published on: 18 April 2011

  6. Review

    Abnormalities of T cell signaling in systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in targ...

    Vaishali R Moulton and George C Tsokos

    Arthritis Research & Therapy 2011 13:207

    Published on: 17 March 2011