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Systemic lupus erythematosus

Written by renowned experts in the field, this collection of review articles provides an in-depth discussion of recent developments in the genetic background, pathogenesis and treatment of systemic lupus erythematosus. An unrestricted educational grant from UCB has enabled BioMed Central to make this series free to access online. UCB has had no input into the content of the series or the articles themselves. All published articles have been independently prepared by the authors, and have been subject to the journal’s standard peer review process.

  1. Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic component and is characterized by chronic inflammation and the production of anti-nuclear auto-antibodies. In the era of genome...

    Authors: Sandra G Guerra, Timothy J Vyse and Deborah S Cunninghame Graham
    Citation: Arthritis Research & Therapy 2012 14:211
  2. Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammatio...

    Authors: Tamara K Nowling and Gary S Gilkeson
    Citation: Arthritis Research & Therapy 2011 13:250
  3. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclea...

    Authors: Thomas Dörner, Claudia Giesecke and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2011 13:243
  4. The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their protein and gene expression profile...

    Authors: Noam Jacob and William Stohl
    Citation: Arthritis Research & Therapy 2011 13:228
  5. The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-react...

    Authors: Annica Hedberg, Elin S Mortensen and Ole P Rekvig
    Citation: Arthritis Research & Therapy 2011 13:214