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Role of lipids and lipid metabolism in cancer

New Content ItemEdited by Christa Buechler and Luiz Fernandes

Lipids in Health and Disease invites you to contribute a manuscript to our new thematic series, “Role of lipids and lipid metabolism in cancer”.

There is emerging evidence that lipids and lipid metabolism are essential for cancer growth. In hepatocellular carcinoma a decline of apoptotic lipids like ceramides is supposed to hinder death of cancer cells. Accumulation of saturated fats may protect the cells from oxidative stress. Enhanced lipogenesis is essential for cell proliferation. Disturbed lipid metabolism was also described in other cancers. The identification of suitable serum lipid biomarkers as diagnostic tools is in the focus of current research. Lipid metabolism may also become a target for cancer therapy.

All submissions should be made by June 30th, 2022.

The collection of papers in this Special Issue addresses the role of lipids and lipid metabolism in cancer. We warmly welcome all articles and reviews on solid and non-solid tumors.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

Please find out more about our journal and its policies, here. Submission guidelines can be found here, and please submit to the series via our submission system (there will be a field for which you can indicate if you are submitting to this series).

  1. The molecular diversity exhibited by diffuse large B-cell lymphoma (DLBCL) is a significant obstacle facing current precision therapies. However, scoring using the International Prognostic Index (IPI) is inade...

    Authors: Zhaoli Zhang, Chong Zhao, Shaoxin Yang, Wei Lu and Jun Shi
    Citation: Lipids in Health and Disease 2024 23:20
  2. Studies have shown that integrating anlotinib with programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors enhances survival rates among progressive non–small-cell lung cancer (NSCLC) patients l...

    Authors: Li Liu, Shuo Zhang, Hai-Yan Yang, Chun-Hua Zhou, Yi Xiong, Nong Yang and Ye Tian
    Citation: Lipids in Health and Disease 2024 23:16
  3. Colorectal cancer (CRC) is a major global health concern, necessitating the identification of biomarkers and molecular subtypes for improved clinical management. This study aims to evaluate the clinical value ...

    Authors: Jing Han, Shangshang Li, Qiong Zhan, Yuchao Hu, Chaoxiang Zhong, Jie Yang and Zhengcai Qiu
    Citation: Lipids in Health and Disease 2023 22:217
  4. Gastric cancer (GC) is a pressing global clinical issue, with few treatment options and a poor prognosis. The onset and spread of stomach cancer are significantly influenced by changes in lipid metabolism-rela...

    Authors: Jinze Zhang, He Wang, Yu Tian, Tianfeng Li, Wei Zhang, Li Ma, Xiangjuan Chen and Yushan Wei
    Citation: Lipids in Health and Disease 2023 22:212
  5. Ceramide, a bioactive signaling sphingolipid, has long been implicated in cancer. Members of the ceramide synthase (CerS) family determine the acyl chain lengths of ceramides, with ceramide synthase 4 (CerS4) ...

    Authors: Su-Jeong Kim, Incheol Seo, Min Hee Kim, Joo-Won Park, Shin Kim and Woo-Jae Park
    Citation: Lipids in Health and Disease 2023 22:183
  6. Adipose tissue, which is mainly composed of adipocytes, is a crucial component of the tumor microenvironment, particularly in breast cancer. Adipocytes surround breast cancer cells and may participate in cell‒...

    Authors: Jinna Wu, Jia Li, Huiya Xu, Ni Qiu, Xiaojia Huang and Hongsheng Li
    Citation: Lipids in Health and Disease 2023 22:153
  7. To explore the impact of visceral obesity (VO) measured by preoperative abdominal computed tomography (CT) on postoperative infectious complications for colorectal cancer (CRC) patients and establish a predict...

    Authors: Wenshan Zhai, Yi Yang, Keyao Zhang, Lei Sun, Meng Luo, Xue Han, Min Wang, Zhiping Wang and Fang Gao
    Citation: Lipids in Health and Disease 2023 22:139
  8. Anlotinib has demonstrated encouraging clinical outcomes in the treatment of lung cancer, soft tissue sarcoma and thyroid carcinoma. Several clinical studies have shown a relationship between anlotinib treatme...

    Authors: Zhongling Zhu, Shan Xu, Jing Ren, Teng Jiang, Cai Zhang and Zhao Yan
    Citation: Lipids in Health and Disease 2023 22:134
  9. This study aimed to investigate the role of cholesterol metabolism-related genes in nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) invading the cavernous sinus and analyze the differences in immun...

    Authors: Tianshun Feng, Pengwei Hou, Shuwen Mu, Yi Fang, Xinxiong Li, Ziqi Li, Di Wang, Li Chen, Lingling Lu, Kunzhe Lin and Shousen Wang
    Citation: Lipids in Health and Disease 2023 22:127
  10. This study analyzed the clinical features and biomarkers of alcohol-associated liver disease (ALD) to investigate the diagnostic value of age, bilirubin, international normalized ratio (INR), and creatinine (A...

    Authors: Xiaoqing Jia, Rong Li, Xiaoting Zhang, Tao Zhou, Dalong Sun, Na Yang and Zheng Luo
    Citation: Lipids in Health and Disease 2023 22:117
  11. Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with limited treatment options, such as the chemotherapeutic agent, temozolomide (TMZ). However, many GBM tumors develop resistance to TMZ, whic...

    Authors: Tzu-Jen Kao, Chien-Liang Lin, Wen-Bin Yang, Hao-Yi Li and Tsung-I Hsu
    Citation: Lipids in Health and Disease 2023 22:114
  12. A previous study demonstrated that low-density lipoprotein cholesterol (LDL-C) is associated with hepatocellular carcinoma (HCC); however, the causality between them has not been proven due to conflicting rese...

    Authors: Jiali Cao, Ziwen Wang, Mengpei Zhu, Yumei Huang, Ze Jin and Zhifan Xiong
    Citation: Lipids in Health and Disease 2023 22:110
  13. As a common malignant tumour, pancreatic cancer (PC) has the worst clinical outcome. Early evaluation of the postoperative prognosis has certain clinical value. Low-density lipoprotein cholesterol (LDL-c), whi...

    Authors: Hanxuan Wang, Yulin Li, Jincan Huang, Youwei Ma, Shaocheng Lyu and Ren Lang
    Citation: Lipids in Health and Disease 2023 22:88
  14. Up to 85% of hepatocellular carcinoma (HCC) cases in China can be attributed to infection of hepatitis B virus (HBV). Lipid metabolism performs important function in hepatocarcinogenesis of HBV–related liver c...

    Authors: Lili Zhou, Shaohuai Xia, Yaoyao Liu, Qiang Ji, Lifeng Li, Xuan Gao, Xiaodi Guo, Xin Yi and Feng Chen
    Citation: Lipids in Health and Disease 2023 22:46
  15. Prostate cancer (PCa), the second most prevalent solid tumor among men worldwide, has caused greatly increasing mortality in PCa patients. The effects of lipid metabolism on tumor growth have been explored, bu...

    Authors: Tianyuan Zhai, Meng Dou, Yubo Ma, Hong Wang, Fang Liu, Liandong Zhang, Tie Chong, Ziming Wang and Li Xue
    Citation: Lipids in Health and Disease 2023 22:39
  16. Little is known about the association between the preoperative low-density lipoprotein cholesterol (LDL-C) level and prognosis in patients with renal cell carcinoma (RCC) after nephrectomy, and its prognostic ...

    Authors: Fan Cui, Huiyu Zhou, Dingyang Lv, Jie Wen, Qian Gong, Yi Rong, Yinbo Kang, Mohan Jia and Weibing Shuang
    Citation: Lipids in Health and Disease 2023 22:26
  17. The risk of postoperative recurrence is higher in lung cancer patients who smoke than non-smokers. However, objective evaluation of the postoperative recurrence risk is difficult using conventional pathologica...

    Authors: Yusuke Takanashi, Tomoaki Kahyo, Takamitsu Hayakawa, Keigo Sekihara, Akikazu Kawase, Minako Kondo, Takuya Kitamoto, Yutaka Takahashi, Tomohito Sato, Haruhiko Sugimura, Norihiko Shiiya, Mitsutoshi Setou and Kazuhito Funai
    Citation: Lipids in Health and Disease 2023 22:15
  18. Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Intestina...

    Authors: Si Qin, Qian Su, Xiang Li, Muqing Shao, Yindi Zhang, Fadong Yu, Yinxing Ni and Jian Zhong
    Citation: Lipids in Health and Disease 2023 22:6
  19. Cholesterol is crucial for tumor immune microenvironment (TIME) remodeling. Serum lipoprotein cholesterol is closely associated with gastric cancer (GC) progression, but whether it affects TIME remodeling is u...

    Authors: Yi Zou, Xiaoyan Yu, Chenqi Zhou, Chunpeng Zhu and Ying Yuan
    Citation: Lipids in Health and Disease 2022 21:150
  20. Lipid metabolism and endoplasmic reticulum (ER) stress play an important role in the progression and metastasis of hepatocellular carcinoma (HCC). We aimed to establish lipid droplet (LD)-associated and ER str...

    Authors: Ziwei Guo and Jun Liang
    Citation: Lipids in Health and Disease 2022 21:146
  21. Visceral obesity is associated with cancer incidence and prognosis. Altered lipid profiles are frequently seen in visceral obese patients. The blood test of lipid profiles is more convenient and has no radical...

    Authors: Bo Gao, Xiangrui Li, Wenqing Chen, Shu’an Wang, Jian He, Yu Liu, Chao Ding and Xiaotian Chen
    Citation: Lipids in Health and Disease 2022 21:102
  22. To explore the relationship between the fatty acid lipophilic index (LI) of the erythrocyte membrane and oral cancer risk, as well as to evaluate the possibility of LI acting as a mediator of the association b...

    Authors: Yi Fan, Qing Chen, Yaping Wang, Jing Wang, Yanni Li, Sijie Wang, Yanfeng Weng, Qiujiao Yang, Chen Chen, Lisong Lin, Yu Qiu, Fa Chen, Jing Wang, Baochang He and Fengqiong Liu
    Citation: Lipids in Health and Disease 2022 21:96
  23. The relationship of consumption of dietary fat and fatty acids with esophageal squamous cell carcinoma (ESCC) risk remains unclear. This study aimed to explore the relationship of dietary fat and fatty acids i...

    Authors: Yu-Xuan Tang, Wenjing Zhao, Jun Li, Peng Xie, Shuyi Wang, Lubin Yan, Xiangbing Xing, Jiahai Lu, Lap-Ah Tse, Harry Hao-Xiang Wang and Xudong Liu
    Citation: Lipids in Health and Disease 2022 21:25
  24. Colorectal cancer (CRC) is one of the most common cancers worldwide characterized by disparities in age, gender, race and anatomic sites. The mechanism underlying pathogenesis, progression and disparities of C...

    Authors: Zhirong Liu, Christian R. Gomez, Ingrid Espinoza, Thuy Phuong T. Le, Veena Shenoy and Xinchun Zhou
    Citation: Lipids in Health and Disease 2022 21:22
  25. 15-lipoxygenase is one of the key enzymes for the metabolism of unsaturated fatty acids that its manipulation has been proposed recently as a new molecular target for regulating cancer cell growth. Aberrant ex...

    Authors: Mohammad Amin Vaezi, Banafsheh Safizadeh, Amir Reza Eghtedari, Seyedeh Sara Ghorbanhosseini, Mostafa Rastegar, Vahid Salimi and Masoumeh Tavakoli-Yaraki
    Citation: Lipids in Health and Disease 2021 20:169
  26. Laparoscopic colorectal surgery causes a lower stress response than open surgery. Adiponectin is mainly derived from adipocytes and has antidiabetic, antioxidative, and anti-inflammatory capabilities. The obje...

    Authors: Wenjiao Shi, Jian Lou, Xiaodan Zhang, Yun Ji, Xiaojian Weng and Jianer Du
    Citation: Lipids in Health and Disease 2021 20:166
  27. Anlotinib, a small molecule for multi-target tyrosine kinase inhibition, is the third or further line of defense for treatment of non-small cell lung cancer (NSCLC). Findings from an ALTER0303 phase III trial ...

    Authors: Mengqiu Tang, Chao Song, Yaowen Zhang, Xiaoyu Xu, Chen Wang, Zhanchun Zhang and Tian Chen
    Citation: Lipids in Health and Disease 2021 20:165
  28. The high drug resistance and metabolic reprogramming of clear cell renal cell carcinoma (ccRCC) are considered responsible for poor prognosis. In-depth research at multiple levels is urgently warranted to illu...

    Authors: Wen Li, Xiaobin Wang, Xianbin Zhang, Peng Gong, Degang Ding, Ning Wang and Zhifeng Wang
    Citation: Lipids in Health and Disease 2021 20:160
  29. Bladder cancer (BLCA) is a common cancer associated with an unfavorable prognosis. Increasing numbers of studies have demonstrated that lipid metabolism affects the progression and treatment of tumors. Therefo...

    Authors: Ke Zhu, Liu Xiaoqiang, Wen Deng, Gongxian Wang and Bin Fu
    Citation: Lipids in Health and Disease 2021 20:146
  30. Breast cancer is one of the main leading causes of women death. In recent years, attention has been focused on the role of lipoproteins, alterations of cholesterol metabolism and oxidative stress in the molecu...

    Authors: Gabriele Mazzuferi, Tiziana Bacchetti, Md Obaidul Islam and Gianna Ferretti
    Citation: Lipids in Health and Disease 2021 20:143
  31. Dysregulated lipid metabolism is critically involved in the development of hepatocellular carcinoma (HCC). The respective metabolic pathways affected in HCC can be identified using suitable experimental models...

    Authors: Elisabeth M. Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch and Christa Buechler
    Citation: Lipids in Health and Disease 2021 20:135
  32. Colorectal cancer (CRC) is a malignancy of the large intestine, whose development and prognosis have been demonstrated to be associated with altered lipid metabolism. High cholesterol intake is associated with...

    Authors: Ryuk Jun Kwon, Eun-Ju Park, Sang Yeoup Lee, Youngin Lee, Chungsu Hwang, Choongrak Kim and Young Hye Cho
    Citation: Lipids in Health and Disease 2021 20:104
  33. Intraductal papillary mucinous neoplasms (IPMNs) can potentially undergo malignant transformation. Studies have shown that high-density lipoprotein cholesterol (HDL-c) was associated with the risk of cancer. I...

    Authors: Cheng Wang, Tingting Lin, Xinru Wang, Zhicheng Yu, Xiaoling Zhuge, Wenjing Cui, Miaomiao Wang, Zhongqiu Wang, Chuangen Guo and Xiao Chen
    Citation: Lipids in Health and Disease 2021 20:94
  34. Accumulating evidence indicates alterations in lipid metabolism and lipid composition in neoplastic tissue. Earlier nuclear magnetic resonance studies showed that the contents of major lipid groups, such as tr...

    Authors: Alicja Pakiet, Kinga Sikora, Jarek Kobiela, Olga Rostkowska, Adriana Mika and Tomasz Sledzinski
    Citation: Lipids in Health and Disease 2021 20:85
  35. Pancreatic cancer is the fourth leading cause of cancer deaths in the United States both in females and in males, and is projected to become the second deadliest cancer by 2030. The overall 5-year survival rat...

    Authors: Rubing Bai, Artur Rebelo, Jörg Kleeff and Yoshiaki Sunami
    Citation: Lipids in Health and Disease 2021 20:58