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Lewy Body Dementia

Edited by Ian McKeith and James Galvin

Lewy body dementia is the second most frequent cause of dementia after Alzheimer’s disease and consists of two related syndromes: dementia with Lewy bodies and Parkinson’s disease dementia. Both syndromes have largely overlapping features and pathologies. This special series, published in Alzheimer's Research & Therapy, takes a translational view of Lewy body dementia from bedside to bench and back.

This series of articles has not been sponsored and all articles have undergone the journal’s standard peer review process overseen by the Series Editors, with final decisions made by the Editors in Chief. The Series Editors and Editors in Chief declare no competing interests.

  1. Review

    Comprehensive treatment of dementia with Lewy bodies

    Dementia with Lewy bodies is an under-recognized disease; it is responsible for up to 20 % of all dementia cases. Accurate diagnosis is essential because the management of dementia with Lewy bodies is more com...

    Brendon P Boot

    Alzheimer's Research & Therapy 2015 7:45

    Published on: 29 May 2015

  2. Research

    Neural correlates of visual hallucinations in dementia with Lewy bodies

    The aim of this study was to investigate the association between visual hallucinations in dementia with Lewy bodies (DLB) and brain perfusion using single-photon emission computed tomography.

    Camille Heitz, Vincent Noblet, Benjamin Cretin, Nathalie Philippi, Laurent Kremer, Mélanie Stackfleth, Fabrice Hubele, Jean Paul Armspach, Izzie Namer and Frédéric Blanc

    Alzheimer's Research & Therapy 2015 7:6

    Published on: 17 February 2015

  3. Research

    The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer’s disease

    Depression and psychosis are two of the most severe neuropsychiatric symptoms (NPS) in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Both NPS have negative effects on cognitive performance and ...

    Yannick Vermeiren, Debby Van Dam, Tony Aerts, Sebastiaan Engelborghs, Jean-Jacques Martin and Peter P De Deyn

    Alzheimer's Research & Therapy 2015 7:7

    Published on: 11 February 2015

  4. Research

    Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test

    Excessive daytime sleepiness is a commonly reported problem in dementia with Lewy bodies (DLB). We examined the relationship between nighttime sleep continuity and the propensity to fall asleep during the day ...

    Tanis J Ferman, Glenn E Smith, Dennis W Dickson, Neill R Graff-Radford, Siong-Chi Lin, Zbigniew Wszolek, Jay A Van Gerpen, Ryan Uitti, David S Knopman, Ronald C Petersen, Joseph E Parisi, Michael H Silber and Bradley F Boeve

    Alzheimer’s Research & Therapy 2014 6:76

    Published on: 10 December 2014

  5. Review

    Alpha-synuclein biology in Lewy body diseases

    α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understanding a group of neurodegenerative disorders called α-synucleinopathies, which are characterized by the presenc...

    Woojin Scott Kim, Katarina Kågedal and Glenda M Halliday

    Alzheimer's Research & Therapy 2014 6:73

    Published on: 27 October 2014

  6. Review

    Biomarkers in biological fluids for dementia with Lewy bodies

    Dementia with Lewy bodies (DLB) has become the second most common neurodegenerative dementia due to demographic ageing. Differential diagnosis is still troublesome especially in early stages of the disease, si...

    Sebastian Schade and Brit Mollenhauer

    Alzheimer's Research & Therapy 2014 6:72

    Published on: 16 October 2014

  7. Research

    Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry

    Compared to Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) is usually associated with a more complex clinical picture and higher burden of care. Yet, few investigations have been performed on comorb...

    Seyed-Mohammad Fereshtehnejad, Soheil Damangir, Pavla Cermakova, Dag Aarsland, Maria Eriksdotter and Dorota Religa

    Alzheimer's Research & Therapy 2014 6:65

    Published on: 6 October 2014

  8. Research

    Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an 11C altropane positron emission tomography study

    The biological basis of cognitive impairment in parkinsonian diseases is believed to be multifactorial. We investigated the contribution of dopamine deficiency to cognition in Parkinson disease (PD) and dement...

    Marta Marquie, Joseph J Locascio, Dorene M Rentz, J Alex Becker, Trey Hedden, Keith A Johnson, John H Growdon and Stephen N Gomperts

    Alzheimer's Research & Therapy 2014 6:52

    Published on: 27 August 2014

  9. Research

    Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

    The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB)...

    Oskar Hansson, Sara Hall, Annika Öhrfelt, Henrik Zetterberg, Kaj Blennow, Lennart Minthon, Katarina Nägga, Elisabet Londos, Shiji Varghese, Nour K Majbour, Abdulmonem Al-Hayani and Omar MA El-Agnaf

    Alzheimer's Research & Therapy 2014 6:25

    Published on: 7 May 2014

  10. Review

    Lewy body dementia: the impact on patients and caregivers

    Lewy body dementia (LBD) is the second most common neurodegenerative dementia in older adults, yet there remains a delay in diagnosis that limits healthcare providers’ ability to maximize therapeutic outcomes ...

    Yael R Zweig and James E Galvin

    Alzheimer's Research & Therapy 2014 6:21

    Published on: 25 April 2014

  11. Review

    Neuroimaging characteristics of dementia with Lewy bodies

    This review summarises the findings and applications from neuroimaging studies in dementia with Lewy bodies (DLB), highlighting key differences between DLB and other subtypes of dementia. We also discuss the i...

    Elijah Mak, Li Su, Guy B Williams and John T O’Brien

    Alzheimer's Research & Therapy 2014 6:18

    Published on: 9 April 2014