Skip to main content

Lewy Body Dementia

Edited by Ian McKeith and James Galvin

Lewy body dementia is the second most frequent cause of dementia after Alzheimer’s disease and consists of two related syndromes: dementia with Lewy bodies and Parkinson’s disease dementia. Both syndromes have largely overlapping features and pathologies. This special series, published in Alzheimer's Research & Therapy, takes a translational view of Lewy body dementia from bedside to bench and back.

This series of articles has not been sponsored and all articles have undergone the journal’s standard peer review process overseen by the Series Editors, with final decisions made by the Editors in Chief. The Series Editors and Editors in Chief declare no competing interests.

  1. Dementia with Lewy bodies is an under-recognized disease; it is responsible for up to 20 % of all dementia cases. Accurate diagnosis is essential because the management of dementia with Lewy bodies is more com...

    Authors: Brendon P Boot
    Citation: Alzheimer's Research & Therapy 2015 7:45
    Content type: Review Published on:

  2. The aim of this study was to investigate the association between visual hallucinations in dementia with Lewy bodies (DLB) and brain perfusion using single-photon emission computed tomography.

    Authors: Camille Heitz, Vincent Noblet, Benjamin Cretin, Nathalie Philippi, Laurent Kremer, Mélanie Stackfleth, Fabrice Hubele, Jean Paul Armspach, Izzie Namer and Frédéric Blanc
    Citation: Alzheimer's Research & Therapy 2015 7:6
    Content type: Research Published on:

  3. Depression and psychosis are two of the most severe neuropsychiatric symptoms (NPS) in dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD). Both NPS have negative effects on cognitive performance and ...

    Authors: Yannick Vermeiren, Debby Van Dam, Tony Aerts, Sebastiaan Engelborghs, Jean-Jacques Martin and Peter P De Deyn
    Citation: Alzheimer's Research & Therapy 2015 7:7
    Content type: Research Published on:

  5. The efficacy of a cholinesterase inhibitor, donepezil, in patients with dementia with Lewy bodies (DLB) was investigated to confirm the superiority over placebo in the 12-week, double-blind phase of this phase...

    Authors: Manabu Ikeda, Etsuro Mori, Kazutaka Matsuo, Masaki Nakagawa and Kenji Kosaka
    Citation: Alzheimer's Research & Therapy 2015 7:4
    Content type: Research Published on:

  6. Excessive daytime sleepiness is a commonly reported problem in dementia with Lewy bodies (DLB). We examined the relationship between nighttime sleep continuity and the propensity to fall asleep during the day ...

    Authors: Tanis J Ferman, Glenn E Smith, Dennis W Dickson, Neill R Graff-Radford, Siong-Chi Lin, Zbigniew Wszolek, Jay A Van Gerpen, Ryan Uitti, David S Knopman, Ronald C Petersen, Joseph E Parisi, Michael H Silber and Bradley F Boeve
    Citation: Alzheimer’s Research & Therapy 2014 6:76
    Content type: Research Published on:

  7. α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understanding a group of neurodegenerative disorders called α-synucleinopathies, which are characterized by the presenc...

    Authors: Woojin Scott Kim, Katarina KÃ¥gedal and Glenda M Halliday
    Citation: Alzheimer's Research & Therapy 2014 6:73
    Content type: Review Published on:

  8. Dementia with Lewy bodies (DLB) has become the second most common neurodegenerative dementia due to demographic ageing. Differential diagnosis is still troublesome especially in early stages of the disease, si...

    Authors: Sebastian Schade and Brit Mollenhauer
    Citation: Alzheimer's Research & Therapy 2014 6:72
    Content type: Review Published on:

  9. Compared to Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) is usually associated with a more complex clinical picture and higher burden of care. Yet, few investigations have been performed on comorb...

    Authors: Seyed-Mohammad Fereshtehnejad, Soheil Damangir, Pavla Cermakova, Dag Aarsland, Maria Eriksdotter and Dorota Religa
    Citation: Alzheimer's Research & Therapy 2014 6:65
    Content type: Research Published on:

  10. The aim of this review was to investigate whether there is a faster cognitive decline in dementia with Lewy bodies (DLB) than in Alzheimer’s disease (AD) over time.

    Authors: Monica H Breitve, Luiza J Chwiszczuk, Minna J Hynninen, Arvid Rongve, Kolbjørn Brønnick, Carmen Janvin and Dag Aarsland
    Citation: Alzheimer's Research & Therapy 2014 6:53
    Content type: Research Published on:

  12. The biological basis of cognitive impairment in parkinsonian diseases is believed to be multifactorial. We investigated the contribution of dopamine deficiency to cognition in Parkinson disease (PD) and dement...

    Authors: Marta Marquie, Joseph J Locascio, Dorene M Rentz, J Alex Becker, Trey Hedden, Keith A Johnson, John H Growdon and Stephen N Gomperts
    Citation: Alzheimer's Research & Therapy 2014 6:52
    Content type: Research Published on:

  14. The objective was to study whether α-synuclein oligomers are altered in the cerebrospinal fluid (CSF) of patients with dementia, including Parkinson disease with dementia (PDD), dementia with Lewy bodies (DLB)...

    Authors: Oskar Hansson, Sara Hall, Annika Öhrfelt, Henrik Zetterberg, Kaj Blennow, Lennart Minthon, Katarina Nägga, Elisabet Londos, Shiji Varghese, Nour K Majbour, Abdulmonem Al-Hayani and Omar MA El-Agnaf
    Citation: Alzheimer's Research & Therapy 2014 6:25
    Content type: Research Published on:

  15. Lewy body dementia (LBD) is the second most common neurodegenerative dementia in older adults, yet there remains a delay in diagnosis that limits healthcare providers’ ability to maximize therapeutic outcomes ...

    Authors: Yael R Zweig and James E Galvin
    Citation: Alzheimer's Research & Therapy 2014 6:21
    Content type: Review Published on:

  16. This review summarises the findings and applications from neuroimaging studies in dementia with Lewy bodies (DLB), highlighting key differences between DLB and other subtypes of dementia. We also discuss the i...

    Authors: Elijah Mak, Li Su, Guy B Williams and John T O’Brien
    Citation: Alzheimer's Research & Therapy 2014 6:18
    Content type: Review Published on: