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The LCNTDR Collection: Advances in scientific research for NTD control

Neglected tropical diseases (NTDs) are a diverse group of 20 diseases that affect over 1.7 billion people globally. These diseases are considered “neglected” because they disproportionately affect people living in poverty, and until recently, were largely overlooked by the international community. Over the past several years, there have been major advances in the areas of advocacy, control implementation funding, cross-sectoral collaboration and drug donation for NTDs. Many new tools are available for NTD diagnosis and the goals of control, elimination and eradication are becoming more feasible. In order to ensure the most effective and efficient use of resources to tackle NTDs, evidence-based research (performed in conjunction with country-based control implementation programmes) must constantly be taking place to evaluate NTD strategies.

The London Centre for Neglected Tropical Disease Research (LCNTDR) was launched in 2013 with the aim of providing focused operational and research support for NTDs. LCNTDR, a joint initiative of the Natural History Museum, the London School of Hygiene & Tropical Medicine, the Royal Veterinary College, the Partnership for Child Development, the SCI Foundation (formerly known as the Schistosomiasis Control Initiative) and Imperial College London, undertakes interdisciplinary research to build the evidence base around the design, implementation, monitoring and evaluation of NTD programmes.

This series features recent advances in scientific research for NTDs executed by LCNTDR member institutions and their collaborators. It aims to highlight the wide range of work being undertaken by the LCNTDR towards achieving the United Nations Sustainable Development Goals well as supporting the objectives of the World Health Organization road map for neglected tropical disease 2021-2030.


View all collections published in Parasites & Vectors


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  1. The majority of schistosomiasis control programmes focus on targeting school-aged children. Expanding the use of community-wide mass treatment to reach more adults is under consideration. However, it should be...

    Authors: Hugo C. Turner, James E. Truscott, Alison A. Bettis, Sam H. Farrell, Arminder K. Deol, Jane M. Whitton, Fiona M. Fleming and Roy M. Anderson
    Citation: Parasites & Vectors 2017 10:213
  2. The filarial nematodes Wuchereria bancrofti (Cobbold, 1877), Brugia malayi (Brug, 1927) and B. timori Partono, Purnomo, Dennis, Atmosoedjono, Oemijati & Cross, 1977 cause lymphatic diseases in humans in the tropi...

    Authors: Shigehiko Uni, Ahmad Syihan Mat Udin, Takeshi Agatsuma, Weerachai Saijuntha, Kerstin Junker, Rosli Ramli, Hasmahzaiti Omar, Yvonne Ai-Lian Lim, Sinnadurai Sivanandam, Emilie Lefoulon, Coralie Martin, Daicus Martin Belabut, Saharul Kasim, Muhammad Rasul Abdullah Halim, Nur Afiqah Zainuri, Subha Bhassu…
    Citation: Parasites & Vectors 2017 10:194
  3. Ocular Chlamydia trachomatis (Ct) infection causes trachoma, the leading infectious cause of blindness. A Ct D/UW3 proteome microarray and sera from Gambian adults with trachomatous trichiasis (TT) or healthy mat...

    Authors: Harry Pickering, Sarah E. Burr, Tamsyn Derrick, Pateh Makalo, Hassan Joof, Richard D. Hayward and Martin J. Holland
    Citation: Parasites & Vectors 2017 10:143
  4. A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is ...

    Authors: Roy Anderson, Sam Farrell, Hugo Turner, Judd Walson, Christl A. Donnelly and James Truscott
    Citation: Parasites & Vectors 2017 10:93
  5. Globally, in 2010, approximately 1.5 billion people were infected with at least one species of soil-transmitted helminth (STH), Ascaris lumbricoides, Trichuris trichiura, hookworm (Ancylostoma duodenale and Necat...

    Authors: William E. Oswald, Aisha E. P. Stewart, Michael R. Kramer, Tekola Endeshaw, Mulat Zerihun, Berhanu Melak, Eshetu Sata, Demelash Gessese, Tesfaye Teferi, Zerihun Tadesse, Birhan Guadie, Jonathan D. King, Paul M. Emerson, Elizabeth K. Callahan, Matthew C. Freeman, W. Dana Flanders…
    Citation: Parasites & Vectors 2017 10:91
  6. The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organiz...

    Authors: Peter Winskill, Wendy E. Harrison, Michael D. French, Matthew A. Dixon, Bernadette Abela-Ridder and María-Gloria Basáñez
    Citation: Parasites & Vectors 2017 10:73
  7. Elimination of urogenital schistosomiasis transmission is a priority for the Zanzibar Ministry of Health. Preventative chemotherapy together with additional control interventions have successfully alleviated m...

    Authors: Tom Pennance, Bobbie Person, Mtumweni Ali Muhsin, Alipo Naim Khamis, Juma Muhsin, Iddi Simba Khamis, Khalfan Abdallah Mohammed, Fatma Kabole, David Rollinson and Stefanie Knopp
    Citation: Parasites & Vectors 2016 9:646
  8. Understanding whether schistosomiasis control programmes are on course to control morbidity and potentially switch towards elimination interventions would benefit from user-friendly quantitative tools that fac...

    Authors: Arminder Deol, Joanne P. Webster, Martin Walker, Maria-Gloria Basáñez, T. Déirdre Hollingsworth, Fiona M. Fleming, Antonio Montresor and Michael D. French
    Citation: Parasites & Vectors 2016 9:543
  9. Vector-biting behaviour is important for vector-borne disease (VBD) epidemiology. The proportion of blood meals taken on humans (the human blood index, HBI), is a component of the biting rate per vector on hum...

    Authors: Poppy H. L. Lamberton, Robert A. Cheke, Martin Walker, Peter Winskill, J. Lee Crainey, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Iñaki Tirados, Michael D. Wilson, Anthony Tetteh-Kumah, Sampson Otoo, Rory J. Post and María-Gloria Basañez
    Citation: Parasites & Vectors 2016 9:432
  10. Trusted literate, or semi-literate, community drug distributors (CDDs) are the primary implementers in integrated preventive chemotherapy (IPC) programmes for Neglected Tropical Disease (NTD) control. The CDDs...

    Authors: Fiona M. Fleming, Fred Matovu, Kristian S. Hansen and Joanne P. Webster
    Citation: Parasites & Vectors 2016 9:345
  11. The African Programme for Onchocerciasis Control has proposed provisional thresholds for the prevalence of microfilariae in humans and of L3 larvae in blackflies, below which mass drug administration (MDA) wit...

    Authors: Christian Bottomley, Valerie Isham, Sarai Vivas-Martínez, Annette C. Kuesel, Simon K. Attah, Nicholas O. Opoku, Sara Lustigman, Martin Walker and Maria-Gloria Basáñez
    Citation: Parasites & Vectors 2016 9:343
  12. Brucella melitensis causes production losses in ruminants and febrile disease in humans in Africa, Central Asia, the Middle East and elsewhere. Although traditionally understood to aff...

    Authors: Wendy Beauvais, Imadidden Musallam and Javier Guitian
    Citation: Parasites & Vectors 2016 9:55
  13. Animal African trypanosomiasis (AAT) is one of the biggest constraints to livestock production and a threat to food security in sub-Saharan Africa. In order to optimise the allocation of resources for AAT cont...

    Authors: H. R. Holt, R. Selby, C. Mumba, G. B. Napier and J. Guitian
    Citation: Parasites & Vectors 2016 9:53
  14. Schistosomiasis affects more than 800 million people, mostly in sub-Saharan Africa. A baseline sentinel site study was conducted in the Western half of Madagascar to determine the prevalence and intensity of s...

    Authors: Clara Fabienne Rasoamanamihaja, Alain Marcel Rahetilahy, Bruno Ranjatoarivony, Neerav Dhanani, Luciano Andriamaro, Samuel Hermas Andrianarisoa and Peter Mark Jourdan
    Citation: Parasites & Vectors 2016 9:50
  15. The clinical outcomes associated with Chagas disease remain poorly understood. In addition to the burden of morbidity, the burden of mortality due to Trypanosoma cruzi infection can be substantial, yet its quanti...

    Authors: Zulma M. Cucunubá, Omolade Okuwoga, María-Gloria Basáñez and Pierre Nouvellet
    Citation: Parasites & Vectors 2016 9:42
  16. By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug a...

    Authors: Martin Walker, Tarub S. Mabud, Piero L. Olliaro, Jean T. Coulibaly, Charles H. King, Giovanna Raso, Alexandra U. Scherrer, J. Russell Stothard, José Carlos Sousa-Figueiredo, Katarina Stete, Jürg Utzinger and Maria-Gloria Basáñez
    Citation: Parasites & Vectors 2016 9:41
  17. The World Health Organization (WHO) has set goals for onchocerciasis elimination in Latin America by 2015. Most of the six previously endemic countries are attaining this goal by implementing twice a year (and...

    Authors: Carlos Botto, María-Gloria Basañez, Marisela Escalona, Néstor J. Villamizar, Oscar Noya-Alarcón, José Cortez, Sarai Vivas-Martínez, Pablo Coronel, Hortencia Frontado, Jorge Flores, Beatriz Graterol, Oneida Camacho, Yseliam Tovar, Daniel Borges, Alba Lucia Morales, Dalila Ríos…
    Citation: Parasites & Vectors 2016 9:40
  18. Soil-transmitted helminth (STH) infections of humans fall within the World Health Organization’s (WHO) grouping termed the neglected tropical diseases (NTDs). It is estimated that they affect approximately 1.4...

    Authors: Julia C. Dunn, Hugo C. Turner, Aung Tun and Roy M. Anderson
    Citation: Parasites & Vectors 2016 9:31
  19. Preventive chemotherapy (PCT) programmes are used to control five of the highest burden neglected tropical diseases (NTDs): soil-transmitted helminth infections (hookworm, ascariasis, and trichuriasis), lympha...

    Authors: Kathryn V. Shuford, Hugo C. Turner and Roy M. Anderson
    Citation: Parasites & Vectors 2016 9:29
  20. Visceral Leishmaniasis (VL) is a neglected vector-borne disease. In India, it is transmitted to humans by Leishmania donovani-infected Phlebotomus argentipes sand flies. In 2005, VL was targeted for elimination b...

    Authors: Mary M. Cameron, Alvaro Acosta-Serrano, Caryn Bern, Marleen Boelaert, Margriet den Boer, Sakib Burza, Lloyd A. C. Chapman, Alexandra Chaskopoulou, Michael Coleman, Orin Courtenay, Simon Croft, Pradeep Das, Erin Dilger, Geraldine Foster, Rajesh Garlapati, Lee Haines…
    Citation: Parasites & Vectors 2016 9:25