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The LCNTDR Collection: Advances in scientific research for NTD control

The neglected tropical diseases (NTDs) are a diverse group of 17 communicable diseases which occur primarily in tropical and subtropical climates, affecting over 149 countries and one billion people globally. These diseases are considered “neglected” because they disproportionately affect people living in poverty, and until recently, were largely overlooked by the international community. Over the past several years, there have been major advances in the areas of advocacy, control implementation funding, and drug donation for NTDs. Many new tools are available for NTD diagnosis and control, and the goal of controlling, or in some cases, eliminating them as a public health problem is becoming more feasible. In order to ensure the most effective and efficient use of the monetary and pharmaceutical commitments to the fight against NTDs, evidence-based research (performed in conjunction with country-based control implementation programmes) must constantly be taking place to evaluate NTD control strategies.

The London Centre for Neglected Tropical Disease Research (LCNTDR) was launched in 2013 with the aim of providing focused operational and research support for NTD control. The LCNTDR, a joint initiative of the Natural History Museum, the London School of Hygiene & Tropical Medicine, the Royal Veterinary College, the Partnership for Child Development, the Schistosomiasis Control Initiative, and Imperial College London, undertakes interdisciplinary research to build the evidence base around the design, implementation, monitoring and evaluation of NTD control and elimination programmes.

This series features recent advances in scientific research for NTD control executed by LCNTDR member institutions and their collaborators. It aims to highlight the wide range of work being undertaken by the LCNTDR towards achieving the United Nations Millennium Development Goals as well as supporting the objectives of the London Declaration on Neglected Tropical Diseases.

Collection published: 27 January 2016

View all collections published in Parasites & Vectors


  1. Research article

    A cross-sectional survey of soil-transmitted helminthiases in two Myanmar villages receiving mass drug administration: epidemiology of infection with a focus on adults

    Soil-transmitted helminths (STH) are still highly prevalent in southeast Asia. The country of Myanmar has had ongoing mass drug administration (MDA) programmes since 2003 in an attempt to control STH and reduc...

    Julia C. Dunn, Alison A. Bettis, Nay Yee Wyine, Aye Moe Moe Lwin, Soe Thiha Lwin, Khine Khine Su, Myint Myint Sein, Aung Tun, Nay Soe Maung and Roy M. Anderson

    Parasites & Vectors 2017 10:374

    Published on: 4 August 2017

  2. Research

    Identifying optimal threshold statistics for elimination of hookworm using a stochastic simulation model

    There is an increased focus on whether mass drug administration (MDA) programmes alone can interrupt the transmission of soil-transmitted helminths (STH). Mathematical models can be used to model these interve...

    James E. Truscott, Marleen Werkman, James E. Wright, Sam H. Farrell, Rajiv Sarkar, Kristjana Ásbjörnsdóttir and Roy M. Anderson

    Parasites & Vectors 2017 10:321

    Published on: 30 June 2017

  3. Research

    Developing a mathematical model for the evaluation of the potential impact of a partially efficacious vaccine on the transmission dynamics of Schistosoma mansoni in human communities

    There is currently no vaccine available to protect humans against infection with the schistosome digenean parasites, although candidate formulations for Schistosoma mansoni are under trial in animal models, inclu...

    Andria Stylianou, Christoforos Hadjichrysanthou, James E. Truscott and Roy M. Anderson

    Parasites & Vectors 2017 10:294

    Published on: 17 June 2017

  4. Research

    Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR

    Understanding and quantifying the sources and implications of error in the measurement of helminth egg intensity using Kato-Katz (KK) and the newly emerging “gold standard” quantitative polymerase chain reacti...

    Alice V. Easton, Rita G. Oliveira, Martin Walker, Elise M. O’Connell, Sammy M. Njenga, Charles S. Mwandawiro, Joanne P. Webster, Thomas B. Nutman and Roy M. Anderson

    Parasites & Vectors 2017 10:256

    Published on: 25 May 2017

  5. Research

    The past matters: estimating intrinsic hookworm transmission intensity in areas with past mass drug administration to control lymphatic filariasis

    Current WHO guidelines for soil-transmitted helminth (STH) control focus on mass drug administration (MDA) targeting preschool-aged (pre-SAC) and school-aged children (SAC), with the goal of eliminating STH as...

    Marleen Werkman, James E. Truscott, Jaspreet Toor, James E. Wright and Roy M. Anderson

    Parasites & Vectors 2017 10:254

    Published on: 23 May 2017

  6. Research

    Evaluating the variation in the projected benefit of community-wide mass treatment for schistosomiasis: Implications for future economic evaluations

    The majority of schistosomiasis control programmes focus on targeting school-aged children. Expanding the use of community-wide mass treatment to reach more adults is under consideration. However, it should be...

    Hugo C. Turner, James E. Truscott, Alison A. Bettis, Sam H. Farrell, Arminder K. Deol, Jane M. Whitton, Fiona M. Fleming and Roy M. Anderson

    Parasites & Vectors 2017 10:213

    Published on: 28 April 2017

  7. Research

    Profiling and validation of individual and patterns of Chlamydia trachomatis-specific antibody responses in trachomatous trichiasis

    Ocular Chlamydia trachomatis (Ct) infection causes trachoma, the leading infectious cause of blindness. A Ct D/UW3 proteome microarray and sera from Gambian adults with trachomatous trichiasis (TT) or healthy mat...

    Harry Pickering, Sarah E. Burr, Tamsyn Derrick, Pateh Makalo, Hassan Joof, Richard D. Hayward and Martin J. Holland

    Parasites & Vectors 2017 10:143

    Published on: 13 March 2017

  8. Research

    Assessing the interruption of the transmission of human helminths with mass drug administration alone: optimizing the design of cluster randomized trials

    A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is ...

    Roy Anderson, Sam Farrell, Hugo Turner, Judd Walson, Christl A. Donnelly and James Truscott

    Parasites & Vectors 2017 10:93

    Published on: 17 February 2017

  9. Research

    Association of community sanitation usage with soil-transmitted helminth infections among school-aged children in Amhara Region, Ethiopia

    Globally, in 2010, approximately 1.5 billion people were infected with at least one species of soil-transmitted helminth (STH), Ascaris lumbricoides, Trichuris trichiura, hookworm (Ancylostoma duodenale and Necat...

    William E. Oswald, Aisha E. P. Stewart, Michael R. Kramer, Tekola Endeshaw, Mulat Zerihun, Berhanu Melak, Eshetu Sata, Demelash Gessese, Tesfaye Teferi, Zerihun Tadesse, Birhan Guadie, Jonathan D. King, Paul M. Emerson, Elizabeth K. Callahan, Matthew C. Freeman, W. Dana Flanders…

    Parasites & Vectors 2017 10:91

    Published on: 17 February 2017

  10. Research

    Assessing the impact of intervention strategies against Taenia solium cysticercosis using the EPICYST transmission model

    The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organiz...

    Peter Winskill, Wendy E. Harrison, Michael D. French, Matthew A. Dixon, Bernadette Abela-Ridder and María-Gloria Basáñez

    Parasites & Vectors 2017 10:73

    Published on: 9 February 2017

  11. Research

    Urogenital schistosomiasis transmission on Unguja Island, Zanzibar: characterisation of persistent hot-spots

    Elimination of urogenital schistosomiasis transmission is a priority for the Zanzibar Ministry of Health. Preventative chemotherapy together with additional control interventions have successfully alleviated m...

    Tom Pennance, Bobbie Person, Mtumweni Ali Muhsin, Alipo Naim Khamis, Juma Muhsin, Iddi Simba Khamis, Khalfan Abdallah Mohammed, Fatma Kabole, David Rollinson and Stefanie Knopp

    Parasites & Vectors 2016 9:646

    Published on: 16 December 2016

  12. Research

    Development and evaluation of a Markov model to predict changes in schistosomiasis prevalence in response to praziquantel treatment: a case study of Schistosoma mansoni in Uganda and Mali

    Understanding whether schistosomiasis control programmes are on course to control morbidity and potentially switch towards elimination interventions would benefit from user-friendly quantitative tools that fac...

    Arminder Deol, Joanne P. Webster, Martin Walker, Maria-Gloria Basáñez, T. Déirdre Hollingsworth, Fiona M. Fleming, Antonio Montresor and Michael D. French

    Parasites & Vectors 2016 9:543

    Published on: 12 October 2016

  13. Research

    Onchocerciasis transmission in Ghana: the human blood index of sibling species of the Simulium damnosum complex

    Vector-biting behaviour is important for vector-borne disease (VBD) epidemiology. The proportion of blood meals taken on humans (the human blood index, HBI), is a component of the biting rate per vector on hum...

    Poppy H. L. Lamberton, Robert A. Cheke, Martin Walker, Peter Winskill, J. Lee Crainey, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Iñaki Tirados, Michael D. Wilson, Anthony Tetteh-Kumah, Sampson Otoo, Rory J. Post and María-Gloria Basañez

    Parasites & Vectors 2016 9:432

    Published on: 5 August 2016

  14. Research

    Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings

    The African Programme for Onchocerciasis Control has proposed provisional thresholds for the prevalence of microfilariae in humans and of L3 larvae in blackflies, below which mass drug administration (MDA) wit...

    Christian Bottomley, Valerie Isham, Sarai Vivas-Martínez, Annette C. Kuesel, Simon K. Attah, Nicholas O. Opoku, Sara Lustigman, Martin Walker and Maria-Gloria Basáñez

    Parasites & Vectors 2016 9:343

    Published on: 14 June 2016

  15. Research

    Functional characterisation of Schistosoma japonicum acetylcholinesterase

    Acetylcholinesterase (AChE) is an important metabolic enzyme of schistosomes present in the musculature and on the surface of the blood stage where it has been implicated in the modulation of glucose scavengin...

    Hong You, Geoffrey N. Gobert, Xiaofeng Du, Gabor Pali, Pengfei Cai, Malcolm K. Jones and Donald P. McManus

    Parasites & Vectors 2016 9:328

    Published on: 10 June 2016

  16. Review

    Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India

    Visceral Leishmaniasis (VL) is a neglected vector-borne disease. In India, it is transmitted to humans by Leishmania donovani-infected Phlebotomus argentipes sand flies. In 2005, VL was targeted for elimination b...

    Mary M. Cameron, Alvaro Acosta-Serrano, Caryn Bern, Marleen Boelaert, Margriet den Boer, Sakib Burza, Lloyd A. C. Chapman, Alexandra Chaskopoulou, Michael Coleman, Orin Courtenay, Simon Croft, Pradeep Das, Erin Dilger, Geraldine Foster, Rajesh Garlapati, Lee Haines…

    Parasites & Vectors 2016 9:25

    Published on: 27 January 2016

  17. Research

    Baseline prevalence and intensity of schistosomiasis at sentinel sites in Madagascar: Informing a national control strategy

    Schistosomiasis affects more than 800 million people, mostly in sub-Saharan Africa. A baseline sentinel site study was conducted in the Western half of Madagascar to determine the prevalence and intensity of s...

    Clara Fabienne Rasoamanamihaja, Alain Marcel Rahetilahy, Bruno Ranjatoarivony, Neerav Dhanani, Luciano Andriamaro, Samuel Hermas Andrianarisoa and Peter Mark Jourdan

    Parasites & Vectors 2016 9:50

    Published on: 27 January 2016

  18. Research

    New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel

    By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug a...

    Martin Walker, Tarub S. Mabud, Piero L. Olliaro, Jean T. Coulibaly, Charles H. King, Giovanna Raso, Alexandra U. Scherrer, J. Russell Stothard, José Carlos Sousa-Figueiredo, Katarina Stete, Jürg Utzinger and Maria-Gloria Basáñez

    Parasites & Vectors 2016 9:41

    Published on: 27 January 2016

  19. Research

    Multi-parallel qPCR provides increased sensitivity and diagnostic breadth for gastrointestinal parasites of humans: field-based inferences on the impact of mass deworming

    Although chronic morbidity in humans from soil transmitted helminth (STH) infections can be reduced by anthelmintic treatment, inconsistent diagnostic tools make it difficult to reliably measure the impact of ...

    Alice V. Easton, Rita G. Oliveira, Elise M. O’Connell, Stella Kepha, Charles S. Mwandawiro, Sammy M. Njenga, Jimmy H. Kihara, Cassian Mwatele, Maurice R. Odiere, Simon J. Brooker, Joanne P. Webster, Roy M. Anderson and Thomas B. Nutman

    Parasites & Vectors 2016 9:38

    Published on: 27 January 2016

  20. Research

    Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus

    The World Health Organization (WHO) has set goals for onchocerciasis elimination in Latin America by 2015. Most of the six previously endemic countries are attaining this goal by implementing twice a year (and...

    Carlos Botto, María-Gloria Basañez, Marisela Escalona, Néstor J. Villamizar, Oscar Noya-Alarcón, José Cortez, Sarai Vivas-Martínez, Pablo Coronel, Hortencia Frontado, Jorge Flores, Beatriz Graterol, Oneida Camacho, Yseliam Tovar, Daniel Borges, Alba Lucia Morales, Dalila Ríos…

    Parasites & Vectors 2016 9:40

    Published on: 27 January 2016

  21. Research

    Can corneal pannus with trachomatous inflammation – follicular be used in combination as an improved specific clinical sign for current ocular Chlamydia trachomatis infection?

    Trachoma is a blinding disease caused by conjunctival infection with Chlamydia trachomatis (Ct). Mass drug administration (MDA) for trachoma control is administered based on the population prevalence of the clini...

    Tamsyn Derrick, Martin J. Holland, Eunice Cassama, Rod Markham-David, Meno Nabicassa, Michael Marks, Robin L. Bailey and Anna R. Last

    Parasites & Vectors 2016 9:30

    Published on: 27 January 2016

  22. Research

    Praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in Zanzibar: a cross-sectional survey

    Biannual mass drug administration (MDA) with praziquantel and additional interventions to eliminate urogenital schistosomiasis has been implemented on the Zanzibar islands, United Republic of Tanzania, since 2...

    Stefanie Knopp, Bobbie Person, Shaali M. Ame, Said M. Ali, Juma Muhsin, Saleh Juma, Iddi S. Khamis, Muriel Rabone, Lynsey Blair, Alan Fenwick, Khalfan A. Mohammed and David Rollinson

    Parasites & Vectors 2016 9:5

    Published on: 4 January 2016

  23. Research

    An economic evaluation of expanding hookworm control strategies to target the whole community

    The WHO treatment guidelines for the soil-transmitted helminths (STH) focus on targeting children for the control of morbidity induced by heavy infections. However, unlike the other STHs, the majority of hookw...

    Hugo C. Turner, James E. Truscott, Alison A. Bettis, Kathryn V. Shuford, Julia C. Dunn, T. Déirdre Hollingsworth, Simon J. Brooker and Roy M. Anderson

    Parasites & Vectors 2015 8:570

    Published on: 5 November 2015

  24. Short Report

    Development of novel multiplex microsatellite polymerase chain reactions to enable high-throughput population genetic studies of Schistosoma haematobium

    Human urogenital schistosomiasis caused by Schistosoma haematobium is widely distributed across Africa and is increasingly targeted for control and regional elimination. The development of new high-throughput, co...

    B. L. Webster, M. Rabone, T. Pennance, A. M. Emery, F. Allan, A. Gouvras, S. Knopp, A. Garba, A. A. Hamidou, K. A. Mohammed, S. M. Ame, D. Rollinson and J. P. Webster

    Parasites & Vectors 2015 8:432

    Published on: 20 August 2015

    The Erratum to this article has been published in Parasites & Vectors 2015 8:519

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