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The LCNTDR Collection: Advances in scientific research for NTD control

The London Centre for Neglected Tropical Disease Research (LCNTDR) is an innovative research collaboration, bringing together leading experts to tackle diseases which affect the lives of over 1.7 billion of the poorest people across the globe.

LCNTDR undertakes cutting-edge research to build the evidence base around the design, implementation and evaluation of neglected tropical disease prevention, control, elimination and eradication programmes.

LCNTDR was launched in 2013 with the aim of providing focused operational and research support for NTD control. LCNTDR member institutions house world renowned NTD experts with a wide range of specialties, making the Centre a valuable resource for cross-sectoral research and collaboration. The founding members of the LCNTDR are the Royal Veterinary CollegeImperial College London, the London School of Hygiene & Tropical Medicine and the Natural History Museum.

From 2021, LCNTDR has been expanding its membership base, welcoming institutions engaged in NTD research based either in London or in countries where NTDs are endemic. New London based institutional members include St George’s University of London, London School of Economics and Politics, University of Greenwich, University of Surrey, Kingston University, UKNEQAS and UCL Hospital for Tropical Diseases.  International members include Ethiopian Public Health Institute, University of Papua New Guinea, C. K. Tedam University of Technology and Applied Sciences (Ghana) and Kwame Nkrumah University of Science and Technology (Ghana).

LCNTDR is committed to addressing the priorities outlined in Ending the neglected to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021-2030, as reflected in our Mission and Objectives. LCNTDR recognises the huge progress made in combatting NTDs since its inception, but also that a commitment to research and innovation is needed to achieve and sustain 2030 road map targets.


View all collections published in Parasites & Vectors


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  1. This paper describes changes in the prevalence and intensity of schistosome parasite infections in a project integrating mass drug administration (MDA), water, sanitation, and hygiene (WaSH), and behavioral ch...

    Authors: Birhan Mengsitu, Ewnetu Firdawek Liyew, Melkie Chernet, Geremew Tasew, Santiago Rayment Gomez, Rosie Maddren, Benjamin Collyer, Ufaysa Anjulo, Adugna Tamiru, Kathryn Forbes, Zelalem Mehari, Kebede Deribe, Teshale Yadeta, Mihretab Salasibew, Getachew Tollera and Roy Anderson
    Citation: Parasites & Vectors 2024 17:113
  2. Despite successful control efforts in China over the past 60 years, zoonotic schistosomiasis caused by Schistosoma japonicum remains a threat with transmission ongoing and the risk of localised resurgences prompt...

    Authors: Daniel A. J. Parsons, Anthony J. Walker, Aidan M. Emery, Joanne P. Webster and Scott P. Lawton
    Citation: Parasites & Vectors 2023 16:97
  3. The Geshiyaro project is a 5-year intervention to assess the impact of community- and school-based water, sanitation, and hygiene (WaSH) interventions on reducing infection with soil-transmitted helminths (STH...

    Authors: Anna E. Phillips, Alison K. Ower, Kalkidan Mekete, Ewnetu Firdawek Liyew, Rosie Maddren, Habtamu Belay, Melkie Chernet, Ufaysa Anjulo, Birhan Mengistu, Mihretab Salasibew, Geremew Tasew and Roy Anderson
    Citation: Parasites & Vectors 2022 15:410
  4. Despite considerable public health efforts over the past 20 years, childhood stunting (physical and/or cognitive) levels globally remain unacceptably high—at 22% amongst children under 5 years old in 2020. The...

    Authors: E. Raj, B. Calvo-Urbano, C. Heffernan, J. Halder and J. P. Webster
    Citation: Parasites & Vectors 2022 15:135
  5. Gastrointestinal (GI) helminth infections cause significant morbidity in both humans and animals worldwide. Specific and sensitive diagnosis is central to the surveillance of such infections and to determine t...

    Authors: Marina Papaiakovou, D. Timothy J. Littlewood, Stephen R. Doyle, Robin B. Gasser and Cinzia Cantacessi
    Citation: Parasites & Vectors 2022 15:118
  6. Schistosomiasis is a disease that poses major threats to human and animal health, as well as the economy, especially in sub-Saharan Africa (SSA). Whilst many studies have evaluated the economic impact of schis...

    Authors: Praise Adeyemo, Elsa Léger, Elizabeth Hollenberg, Nicolas Diouf, Mariama Sène, Joanne P. Webster and Barbara Häsler
    Citation: Parasites & Vectors 2022 15:101
  7. In January 2021, the World Health Organization published the 2021–2030 roadmap for the control of neglected tropical diseases (NTDs). The goal for schistosomiasis is to achieve elimination as a public health p...

    Authors: Klodeta Kura, Diepreye Ayabina, T. Deirdre Hollingsworth and Roy M. Anderson
    Citation: Parasites & Vectors 2022 15:55
  8. Cysticercosis is a zoonotic neglected tropical disease (NTD) that affects humans and pigs following the ingestion of Taenia solium eggs. Human cysticercosis poses a substantial public health burden in endemic cou...

    Authors: Erika Galipó, Matthew A. Dixon, Claudio Fronterrè, Zulma M. Cucunubá, Maria-Gloria Basáñez, Kim Stevens, Astrid Carolina Flórez Sánchez and Martin Walker
    Citation: Parasites & Vectors 2021 14:590
  9. Chagas disease remains a significant public health problem in Latin America. There are only two chemotherapy drugs, nifurtimox and benznidazole, and both may have severe side effects. After complete chemothera...

    Authors: Niamh Murphy, M. Victoria Cardinal, Tapan Bhattacharyya, Gustavo F. Enriquez, Natalia P. Macchiaverna, Alejandra Alvedro, Héctor Freilij, Pablo Martinez de Salazar, Israel Molina, Pascal Mertens, Quentin Gilleman, Ricardo E. Gürtler and Michael A. Miles
    Citation: Parasites & Vectors 2021 14:543
  10. Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One go...

    Authors: Carolin Vegvari, Federica Giardina, Sumali Bajaj, Veronica Malizia, Robert J. Hardwick, James E. Truscott, Antonio Montresor, Sake J. de Vlas, Luc E. Coffeng and Roy M. Anderson
    Citation: Parasites & Vectors 2021 14:220
  11. Ethiopia has set the ambitious national targets of eliminating soil-transmitted helminths (STH) and schistosomiasis (SCH) as public health problems by 2020, and breaking their transmission by 2025. This system...

    Authors: Rosie Maddren, Anna Phillips, Alison Ower, Toby Landeryou, Birhan Mengistu, Ufaysa Anjulo, Ewnetu Firdawek, Nebiyu Negussu and Roy Anderson
    Citation: Parasites & Vectors 2021 14:97

    The Correction to this article has been published in Parasites & Vectors 2023 16:203

  12. The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study site...

    Authors: James E. Truscott, Robert J. Hardwick, Marleen Werkman, Puthupalayam Kaliappan Saravanakumar, Malathi Manuel, Sitara S. R. Ajjampur, Kristjana H. Ásbjörnsdóttir, Kalua Khumbo, Stefan Witek-McManus, James Simwanza, Gilles Cottrell, Parfait Houngbégnon, Moudachirou Ibikounlé, Judd L. Walson and Roy M. Anderson
    Citation: Parasites & Vectors 2021 14:67
  13. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinated a five-year study implemented in several countries, including Niger, to provide an evidence-base for programmatic deci...

    Authors: Anna E. Phillips, Zilahatou Tohon, Neerav A. Dhanani, Boubacar Sofo, Issa Gnandou, Boubacar Sidikou, Adamou Garba Noma, Bassirou Madougou, Oumarou Alto, Hannatou Sebangou, Kader M. Halilou, Roumanatou Andia, Amadou Garba, Alan Fenwick and Amina A. Hamidou
    Citation: Parasites & Vectors 2020 13:557
  14. The World Health Organization-recommended strategy for trachoma elimination as a public health problem is known by the acronym “SAFE”, where “F” stands for facial cleanliness to reduce transmission of ocular Chla...

    Authors: Emma M. Harding-Esch, Martin J. Holland, Jean-François Schémann, Mactar Sissoko, Boubacar Sarr, Robert M. R. Butcher, Sandra Molina-Gonzalez, Aura A. Andreasen, David C. W. Mabey and Robin L. Bailey
    Citation: Parasites & Vectors 2020 13:556
  15. Schistosomiasis control programmes primarily use school-based surveys to identify areas for mass drug administration of preventive chemotherapy. However, as the spatial distribution of schistosomiasis can be h...

    Authors: Kimberly M Fornace, Claudio Fronterrè, Fiona M. Fleming, Hope Simpson, Honorat Zoure, Maria Rebollo, Pauline Mwinzi, Penelope Vounatsou and Rachel L. Pullan
    Citation: Parasites & Vectors 2020 13:555
  16. Schistosomiasis remains an endemic parasitic disease causing much morbidity and, in some cases, mortality. The World Health Organization (WHO) has outlined strategies and goals to combat the burden of disease ...

    Authors: Klodeta Kura, Robert J. Hardwick, James E. Truscott, Jaspreet Toor, T. Deirdre Hollingsworth and Roy M. Anderson
    Citation: Parasites & Vectors 2020 13:554
  17. The clinical signs of active trachoma are often present in the absence of ocular Chlamydia trachomatis infection, particularly following mass drug administration. Treatment decisions following impact surveys and ...

    Authors: Tamsyn R. Derrick, Natalia Sandetskaya, Harry Pickering, Andreas Kölsch, Athumani Ramadhani, Elias Mafuru, Patrick Massae, Aiweda Malisa, Tara Mtuy, Matthew J. Burton, Martin J. Holland and Dirk Kuhlmeier
    Citation: Parasites & Vectors 2020 13:533
  18. The most commonly used diagnostic tool for soil-transmitted helminths (STH) is the Kato-Katz (KK) thick smear technique. However, numerous studies have suggested that the sensitivity of KK can be problematic, ...

    Authors: Julia C. Dunn, Marina Papaiakovou, Kay Thwe Han, Darren Chooneea, Alison A. Bettis, Nay Yee Wyine, Aye Moe Moe Lwin, Nay Soe Maung, Raju Misra, D. T. J. Littlewood and Roy M. Anderson
    Citation: Parasites & Vectors 2020 13:324
  19. Urogenital schistosomiasis, caused by infection with Schistosoma haematobium, is endemic in Niger but complicated by the presence of Schistosoma bovis, Schistosoma curassoni and S. haematobium group hybrids along...

    Authors: Tom Pennance, Fiona Allan, Aidan Emery, Muriel Rabone, Jo Cable, Amadou Djirmay Garba, Amina Amadou Hamidou, Joanne P. Webster, David Rollinson and Bonnie L. Webster
    Citation: Parasites & Vectors 2020 13:268
  20. Dengue is a mosquito-borne viral disease caused by one of four serotypes (DENV1-4). Infection provides long-term homologous immunity against reinfection with the same serotype. Plaque reduction neutralization ...

    Authors: Sorawat Sangkaew, Li Kiang Tan, Lee Ching Ng, Neil M. Ferguson and Ilaria Dorigatti
    Citation: Parasites & Vectors 2020 13:32
  21. Trachoma, caused by ocular Chlamydia trachomatis, is the leading infectious cause of blindness worldwide. Sudan first reported trachoma in the 1930s and has since been consistently endemic. Ocular C. trachomatis ...

    Authors: Abdulazeem Abdulsalam Ibrahim Alkhidir, Martin J. Holland, Wafa Ibrahim Elhag, Charlotte A. Williams, Judith Breuer, Abdah Elfatih Elemam, Khalid Mohamed Khalid El Hussain, Mohammed Elfatih Hussein Ournasseir and Harry Pickering
    Citation: Parasites & Vectors 2019 12:518
  22. Accurate diagnosis of urogenital schistosomiasis is vital for surveillance and control programmes. While a number of diagnostic techniques are available there is a need for simple, rapid and highly sensitive p...

    Authors: Penelope Rostron, Tom Pennance, Faki Bakar, David Rollinson, Stefanie Knopp, Fiona Allan, Fatma Kabole, Said M. Ali, Shaali M. Ame and Bonnie L. Webster
    Citation: Parasites & Vectors 2019 12:514
  23. National deworming programmes rely almost exclusively on mass drug administration (MDA) to children to control morbidity caused by these parasitic infections. The provision of other interventions, consisting o...

    Authors: Kalkidan Mekete, Alison Ower, Julia Dunn, Heven Sime, Gemechu Tadesse, Ebba Abate, Nebiyu Nigussu, Fikreselasie Seife, Emily McNaughton, Roy Malcolm Anderson and Anna Elizabeth Phillips
    Citation: Parasites & Vectors 2019 12:503
  24. Schistosomiasis is a neglected tropical disease, targeted by the World Health Organization for reduction in morbidity by 2020. It is caused by parasitic flukes that spread through contamination of local water ...

    Authors: Benjamin S. Collyer, Hugo C. Turner, T. Déirdre Hollingsworth and Matt J. Keeling
    Citation: Parasites & Vectors 2019 12:499
  25. Sound knowledge of the abundance and distribution of intermediate host snails is key to understanding schistosomiasis transmission and to inform effective interventions in endemic areas.

    Authors: Muriel Rabone, Joris Hendrik Wiethase, Fiona Allan, Anouk Nathalie Gouvras, Tom Pennance, Amina Amadou Hamidou, Bonnie Lee Webster, Rabiou Labbo, Aidan Mark Emery, Amadou Djirmay Garba and David Rollinson
    Citation: Parasites & Vectors 2019 12:498
  26. Mass drug administration (MDA) with azithromycin is a cornerstone of the trachoma elimination strategy. Although the global prevalence of active trachoma has declined considerably, prevalence persists or even ...

    Authors: Emma M. Harding-Esch, Martin J. Holland, Jean-François Schémann, Ansumana Sillah, Boubacar Sarr, Linus Christerson, Harry Pickering, Sandra Molina-Gonzalez, Isatou Sarr, Aura A. Andreasen, David Jeffries, Chris Grundy, David C. W. Mabey, Bjorn Herrmann and Robin L. Bailey
    Citation: Parasites & Vectors 2019 12:497
  27. The strategy of pooling stool specimens has been extensively used in the field of parasitology in order to facilitate the screening of large numbers of samples whilst minimizing the prohibitive cost of single ...

    Authors: Marina Papaiakovou, James Wright, Nils Pilotte, Darren Chooneea, Fabian Schär, James E. Truscott, Julia C. Dunn, Iain Gardiner, Judd L. Walson, Steven A. Williams and D. Timothy J. Littlewood
    Citation: Parasites & Vectors 2019 12:443
  28. As many countries with endemic soil-transmitted helminth (STH) burdens achieve high coverage levels of mass drug administration (MDA) to treat school-aged and pre-school-aged children, understanding the detail...

    Authors: James E. Truscott, Alison K. Ower, Marleen Werkman, Katherine Halliday, William E. Oswald, Paul M. Gichuki, Carlos Mcharo, Simon Brooker, Sammy M. Njenga, Charles Mwandariwo, Judd L. Walson, Rachel Pullan and Roy Anderson
    Citation: Parasites & Vectors 2019 12:442
  29. Sibship reconstruction is a form of parentage analysis that can be used to identify the number of helminth parental genotypes infecting individual hosts using genetic data on only their offspring. This has the...

    Authors: M. Inês Neves, Joanne P. Webster and Martin Walker
    Citation: Parasites & Vectors 2019 12:441
  30. The baseline endemicity profile of lymphatic filariasis (LF) is a key benchmark for planning control programmes, monitoring their impact on transmission and assessing the feasibility of achieving elimination. ...

    Authors: Obiora A. Eneanya, Claudio Fronterre, Ifeoma Anagbogu, Chukwu Okoronkwo, Tini Garske, Jorge Cano and Christl A. Donnelly
    Citation: Parasites & Vectors 2019 12:440
  31. Schistosomiasis and food-borne trematodiases are not only of major public health concern, but can also have profound implications for livestock production and wildlife conservation. The zoonotic, multi-host na...

    Authors: Stefano Catalano, Amelia Symeou, Kirsty J. Marsh, Anna Borlase, Elsa Léger, Cheikh B. Fall, Mariama Sène, Nicolas D. Diouf, Davide Ianniello, Giuseppe Cringoli, Laura Rinaldi, Khalilou Bâ and Joanne P. Webster
    Citation: Parasites & Vectors 2019 12:439
  32. Soil-transmitted helminth (STH) infections affect predominantly socio-economically disadvantaged populations in sub-Saharan Africa, East Asia and the Americas. Previous mathematical modelling studies have eval...

    Authors: Carolin Vegvari, James E. Truscott, Klodeta Kura and Roy M. Anderson
    Citation: Parasites & Vectors 2019 12:438
  33. The World Health Organization (WHO) has set elimination (interruption of transmission) as an end goal for schistosomiasis. However, there is currently little guidance on the monitoring and evaluation strategy ...

    Authors: Jaspreet Toor, James E. Truscott, Marleen Werkman, Hugo C. Turner, Anna E. Phillips, Charles H. King, Graham F. Medley and Roy M. Anderson
    Citation: Parasites & Vectors 2019 12:437
  34. Trypanosoma cruzi, the protozoan agent of Chagas disease, is comprised of at least 6 genetic lineages (TcI-TcVI). Their geographical distribution, clinical associations and reservoir hosts are not fully elucidate...

    Authors: Niamh Murphy, Natalia P. Macchiaverna, M. Victoria Cardinal, Tapan Bhattacharyya, Pascal Mertens, Nicolas Zeippen, Yves Gustin, Quentin Gilleman, Ricardo E. Gürtler and Michael A. Miles
    Citation: Parasites & Vectors 2019 12:424
  35. Urine filtration and microhaematuria reagent strips are basic standard diagnostic methods to detect urogenital schistosomiasis. We assessed their accuracy for the diagnosis of light intensity infections with Schi...

    Authors: Stefanie Knopp, Shaali M Ame, Jan Hattendorf, Said M Ali, Iddi S Khamis, Faki Bakar, Mwanaidi A Khamis, Bobbie Person, Fatma Kabole and David Rollinson
    Citation: Parasites & Vectors 2018 11:552

    The Correction to this article has been published in Parasites & Vectors 2019 12:149

  36. Infections with soil-transmitted helminths and pathogenic intestinal protozoa pose a considerable public health burden, particularly in low- and middle-income countries, including Nepal. We assessed the extent...

    Authors: Akina Shrestha, Christian Schindler, Peter Odermatt, Jana Gerold, Séverine Erismann, Subodh Sharma, Rajendra Koju, Jürg Utzinger and Guéladio Cissé
    Citation: Parasites & Vectors 2018 11:532
  37. Biting aquatic insects belonging to the order Hemiptera have been suggested as potential vectors of Mycobacterium ulcerans in endemic areas for Buruli ulcer (BU). If this is the case, these insects would be expec...

    Authors: Jorge Cano, Antonio Rodríguez, Hope Simpson, Earnest N. Tabah, Jose F. Gómez and Rachel L. Pullan
    Citation: Parasites & Vectors 2018 11:501
  38. In 2012, the World Health Organization set goals for the elimination of onchocerciasis transmission by 2020 in selected African countries. Epidemiological data and mathematical modelling have indicated that el...

    Authors: Isobel Routledge, Martin Walker, Robert A. Cheke, Samir Bhatt, Pierre Baleguel Nkot, Graham A. Matthews, Didier Baleguel, Hans M. Dobson, Terry L. Wiles and Maria-Gloria Basañez
    Citation: Parasites & Vectors 2018 11:316
  39. Clinical signs of active (inflammatory) trachoma are found in many children in the Solomon Islands, but the majority of these individuals have no serological evidence of previous infection with Chlamydia trachoma...

    Authors: Hristina Vasileva, Robert Butcher, Harry Pickering, Oliver Sokana, Kelvin Jack, Anthony W. Solomon, Martin J. Holland and Chrissy h. Roberts
    Citation: Parasites & Vectors 2018 11:104
  40. Trachoma, the leading infectious cause of blindness worldwide, is caused by conjunctival Chlamydia trachomatis infection. Trachoma is diagnosed clinically by observation of conjunctival inflammation and/or scarri...

    Authors: Harry Pickering, Martin J. Holland, Anna R. Last, Matthew J. Burton and Sarah E. Burr
    Citation: Parasites & Vectors 2018 11:102
  41. Visceral leishmaniasis (VL) is a neglected tropical disease (NTD), caused by the intracellular protozoan parasites Leishmania donovani and Leishmania infantum. Symptomatic VL is considered fatal when left untreat...

    Authors: Francisco J. Salguero, Waldo L. Garcia-Jimenez, Isadora Lima and Karin Seifert
    Citation: Parasites & Vectors 2018 11:73
  42. Onchocerciasis and lymphatic filariasis (LF) are major filarial infections targeted for elimination in most endemic sub-Saharan Africa (SSA) countries by 2020/2025. The current control strategies are built upo...

    Authors: Jorge Cano, Maria-Gloria Basáñez, Simon J. O’Hanlon, Afework H. Tekle, Samuel Wanji, Honorat G. Zouré, Maria P. Rebollo and Rachel L. Pullan
    Citation: Parasites & Vectors 2018 11:70
  43. The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are in...

    Authors: James E. Wright, Marleen Werkman, Julia C. Dunn and Roy M. Anderson
    Citation: Parasites & Vectors 2018 11:65
  44. Trachoma, a neglected tropical disease, is caused by ocular infection with Chlamydia trachomatis (Ct). The World Health Organization (WHO) recommends three annual rounds of community mass drug treatment with azit...

    Authors: Anna R. Last, Sarah E. Burr, Emma Harding-Esch, Eunice Cassama, Meno Nabicassa, Chrissy h. Roberts, David C. W. Mabey, Martin J. Holland and Robin L. Bailey
    Citation: Parasites & Vectors 2017 10:624
  45. Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Che...

    Authors: Charlotte M. Gower, Florian Gehre, Sara R. Marques, Poppy H. L. Lamberton, Nicholas J. Lwambo and Joanne P. Webster
    Citation: Parasites & Vectors 2017 10:593
  46. Investigating the effect of successive annual deworming rounds on the spatiotemporal distribution of infection prevalence and numbers at risk for soil-transmitted helminths (STHs) can help identify communities...

    Authors: Mohamad Assoum, Giuseppina Ortu, Maria-Gloria Basáñez, Colleen Lau, Archie C. A. Clements, Kate Halton, Alan Fenwick and Ricardo J. Soares Magalhães
    Citation: Parasites & Vectors 2017 10:583
  47. Soil-transmitted helminths (STH) are still highly prevalent in southeast Asia. The country of Myanmar has had ongoing mass drug administration (MDA) programmes since 2003 in an attempt to control STH and reduc...

    Authors: Julia C. Dunn, Alison A. Bettis, Nay Yee Wyine, Aye Moe Moe Lwin, Soe Thiha Lwin, Khine Khine Su, Myint Myint Sein, Aung Tun, Nay Soe Maung and Roy M. Anderson
    Citation: Parasites & Vectors 2017 10:374