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The LCNTDR Collection: Advances in scientific research for NTD control

The neglected tropical diseases (NTDs) are a diverse group of 17 communicable diseases which occur primarily in tropical and subtropical climates, affecting over 149 countries and one billion people globally. These diseases are considered “neglected” because they disproportionately affect people living in poverty, and until recently, were largely overlooked by the international community. Over the past several years, there have been major advances in the areas of advocacy, control implementation funding, and drug donation for NTDs. Many new tools are available for NTD diagnosis and control, and the goal of controlling, or in some cases, eliminating them as a public health problem is becoming more feasible. In order to ensure the most effective and efficient use of the monetary and pharmaceutical commitments to the fight against NTDs, evidence-based research (performed in conjunction with country-based control implementation programmes) must constantly be taking place to evaluate NTD control strategies.

The London Centre for Neglected Tropical Disease Research (LCNTDR) was launched in 2013 with the aim of providing focused operational and research support for NTD control. The LCNTDR, a joint initiative of the Natural History Museum, the London School of Hygiene & Tropical Medicine, the Royal Veterinary College, the Partnership for Child Development, the Schistosomiasis Control Initiative, and Imperial College London, undertakes interdisciplinary research to build the evidence base around the design, implementation, monitoring and evaluation of NTD control and elimination programmes.

This series features recent advances in scientific research for NTD control executed by LCNTDR member institutions and their collaborators. It aims to highlight the wide range of work being undertaken by the LCNTDR towards achieving the United Nations Millennium Development Goals as well as supporting the objectives of the London Declaration on Neglected Tropical Diseases.

Collection published: 27 January 2016

View all collections published in Parasites & Vectors

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  1. Content type: Research

    Clinical signs of active (inflammatory) trachoma are found in many children in the Solomon Islands, but the majority of these individuals have no serological evidence of previous infection with Chlamydia trachoma...

    Authors: Hristina Vasileva, Robert Butcher, Harry Pickering, Oliver Sokana, Kelvin Jack, Anthony W. Solomon, Martin J. Holland and Chrissy h. Roberts

    Citation: Parasites & Vectors 2018 11:104

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  2. Content type: Research

    Trachoma, the leading infectious cause of blindness worldwide, is caused by conjunctival Chlamydia trachomatis infection. Trachoma is diagnosed clinically by observation of conjunctival inflammation and/or scarri...

    Authors: Harry Pickering, Martin J. Holland, Anna R. Last, Matthew J. Burton and Sarah E. Burr

    Citation: Parasites & Vectors 2018 11:102

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  3. Content type: Review

    The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are in...

    Authors: James E. Wright, Marleen Werkman, Julia C. Dunn and Roy M. Anderson

    Citation: Parasites & Vectors 2018 11:65

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  4. Content type: Short report

    Onchocerciasis and lymphatic filariasis (LF) are major filarial infections targeted for elimination in most endemic sub-Saharan Africa (SSA) countries by 2020/2025. The current control strategies are built upo...

    Authors: Jorge Cano, Maria-Gloria Basáñez, Simon J. O’Hanlon, Afework H. Tekle, Samuel Wanji, Honorat G. Zouré, Maria P. Rebollo and Rachel L. Pullan

    Citation: Parasites & Vectors 2018 11:70

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  5. Content type: Research

    Visceral leishmaniasis (VL) is a neglected tropical disease (NTD), caused by the intracellular protozoan parasites Leishmania donovani and Leishmania infantum. Symptomatic VL is considered fatal when left untreat...

    Authors: Francisco J. Salguero, Waldo L. Garcia-Jimenez, Isadora Lima and Karin Seifert

    Citation: Parasites & Vectors 2018 11:73

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  6. Content type: Research

    Trachoma, a neglected tropical disease, is caused by ocular infection with Chlamydia trachomatis (Ct). The World Health Organization (WHO) recommends three annual rounds of community mass drug treatment with azit...

    Authors: Anna R. Last, Sarah E. Burr, Emma Harding-Esch, Eunice Cassama, Meno Nabicassa, Chrissy h. Roberts, David C. W. Mabey, Martin J. Holland and Robin L. Bailey

    Citation: Parasites & Vectors 2017 10:624

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  7. Content type: Research

    Schistosoma mansoni is a parasite of profound medical importance. Current control focusses on mass praziquantel (PZQ) treatment of populations in endemic areas, termed Preventative Che...

    Authors: Charlotte M. Gower, Florian Gehre, Sara R. Marques, Poppy H. L. Lamberton, Nicholas J. Lwambo and Joanne P. Webster

    Citation: Parasites & Vectors 2017 10:593

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  8. Content type: Research

    Investigating the effect of successive annual deworming rounds on the spatiotemporal distribution of infection prevalence and numbers at risk for soil-transmitted helminths (STHs) can help identify communities...

    Authors: Mohamad Assoum, Giuseppina Ortu, Maria-Gloria Basáñez, Colleen Lau, Archie C. A. Clements, Kate Halton, Alan Fenwick and Ricardo J. Soares Magalhães

    Citation: Parasites & Vectors 2017 10:583

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  9. Content type: Research article

    Soil-transmitted helminths (STH) are still highly prevalent in southeast Asia. The country of Myanmar has had ongoing mass drug administration (MDA) programmes since 2003 in an attempt to control STH and reduc...

    Authors: Julia C. Dunn, Alison A. Bettis, Nay Yee Wyine, Aye Moe Moe Lwin, Soe Thiha Lwin, Khine Khine Su, Myint Myint Sein, Aung Tun, Nay Soe Maung and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:374

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  10. Content type: Research

    There is an increased focus on whether mass drug administration (MDA) programmes alone can interrupt the transmission of soil-transmitted helminths (STH). Mathematical models can be used to model these interve...

    Authors: James E. Truscott, Marleen Werkman, James E. Wright, Sam H. Farrell, Rajiv Sarkar, Kristjana Ásbjörnsdóttir and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:321

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  11. Content type: Research

    There is currently no vaccine available to protect humans against infection with the schistosome digenean parasites, although candidate formulations for Schistosoma mansoni are under trial in animal models, inclu...

    Authors: Andria Stylianou, Christoforos Hadjichrysanthou, James E. Truscott and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:294

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  12. Content type: Research

    Systematic non-compliance to chemotherapeutic treatment among a portion of the eligible population is thought to be a major obstacle to the elimination of helminth infections by mass drug administration (MDA)....

    Authors: Sam H. Farrell, James E. Truscott and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:291

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  13. Content type: Research

    Understanding and quantifying the sources and implications of error in the measurement of helminth egg intensity using Kato-Katz (KK) and the newly emerging “gold standard” quantitative polymerase chain reacti...

    Authors: Alice V. Easton, Rita G. Oliveira, Martin Walker, Elise M. O’Connell, Sammy M. Njenga, Charles S. Mwandawiro, Joanne P. Webster, Thomas B. Nutman and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:256

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  14. Content type: Research

    Current WHO guidelines for soil-transmitted helminth (STH) control focus on mass drug administration (MDA) targeting preschool-aged (pre-SAC) and school-aged children (SAC), with the goal of eliminating STH as...

    Authors: Marleen Werkman, James E. Truscott, Jaspreet Toor, James E. Wright and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:254

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  15. Content type: Research

    The majority of schistosomiasis control programmes focus on targeting school-aged children. Expanding the use of community-wide mass treatment to reach more adults is under consideration. However, it should be...

    Authors: Hugo C. Turner, James E. Truscott, Alison A. Bettis, Sam H. Farrell, Arminder K. Deol, Jane M. Whitton, Fiona M. Fleming and Roy M. Anderson

    Citation: Parasites & Vectors 2017 10:213

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  16. Content type: Research

    Ocular Chlamydia trachomatis (Ct) infection causes trachoma, the leading infectious cause of blindness. A Ct D/UW3 proteome microarray and sera from Gambian adults with trachomatous trichiasis (TT) or healthy mat...

    Authors: Harry Pickering, Sarah E. Burr, Tamsyn Derrick, Pateh Makalo, Hassan Joof, Richard D. Hayward and Martin J. Holland

    Citation: Parasites & Vectors 2017 10:143

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  17. Content type: Research

    A method is outlined for the use of an individual-based stochastic model of parasite transmission dynamics to assess different designs for a cluster randomized trial in which mass drug administration (MDA) is ...

    Authors: Roy Anderson, Sam Farrell, Hugo Turner, Judd Walson, Christl A. Donnelly and James Truscott

    Citation: Parasites & Vectors 2017 10:93

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  18. Content type: Research

    Globally, in 2010, approximately 1.5 billion people were infected with at least one species of soil-transmitted helminth (STH), Ascaris lumbricoides, Trichuris trichiura, hookworm (Ancylostoma duodenale and Necat...

    Authors: William E. Oswald, Aisha E. P. Stewart, Michael R. Kramer, Tekola Endeshaw, Mulat Zerihun, Berhanu Melak, Eshetu Sata, Demelash Gessese, Tesfaye Teferi, Zerihun Tadesse, Birhan Guadie, Jonathan D. King, Paul M. Emerson, Elizabeth K. Callahan, Matthew C. Freeman, W. Dana Flanders…

    Citation: Parasites & Vectors 2017 10:91

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  19. Content type: Research

    The pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organiz...

    Authors: Peter Winskill, Wendy E. Harrison, Michael D. French, Matthew A. Dixon, Bernadette Abela-Ridder and María-Gloria Basáñez

    Citation: Parasites & Vectors 2017 10:73

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  20. Content type: Research

    Elimination of urogenital schistosomiasis transmission is a priority for the Zanzibar Ministry of Health. Preventative chemotherapy together with additional control interventions have successfully alleviated m...

    Authors: Tom Pennance, Bobbie Person, Mtumweni Ali Muhsin, Alipo Naim Khamis, Juma Muhsin, Iddi Simba Khamis, Khalfan Abdallah Mohammed, Fatma Kabole, David Rollinson and Stefanie Knopp

    Citation: Parasites & Vectors 2016 9:646

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  21. Content type: Research

    Understanding whether schistosomiasis control programmes are on course to control morbidity and potentially switch towards elimination interventions would benefit from user-friendly quantitative tools that fac...

    Authors: Arminder Deol, Joanne P. Webster, Martin Walker, Maria-Gloria Basáñez, T. Déirdre Hollingsworth, Fiona M. Fleming, Antonio Montresor and Michael D. French

    Citation: Parasites & Vectors 2016 9:543

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  22. Content type: Research

    Vector-biting behaviour is important for vector-borne disease (VBD) epidemiology. The proportion of blood meals taken on humans (the human blood index, HBI), is a component of the biting rate per vector on hum...

    Authors: Poppy H. L. Lamberton, Robert A. Cheke, Martin Walker, Peter Winskill, J. Lee Crainey, Daniel A. Boakye, Mike Y. Osei-Atweneboana, Iñaki Tirados, Michael D. Wilson, Anthony Tetteh-Kumah, Sampson Otoo, Rory J. Post and María-Gloria Basañez

    Citation: Parasites & Vectors 2016 9:432

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  23. Content type: Research

    Trusted literate, or semi-literate, community drug distributors (CDDs) are the primary implementers in integrated preventive chemotherapy (IPC) programmes for Neglected Tropical Disease (NTD) control. The CDDs...

    Authors: Fiona M. Fleming, Fred Matovu, Kristian S. Hansen and Joanne P. Webster

    Citation: Parasites & Vectors 2016 9:345

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