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Lobular Breast Cancer

This special series takes a translational view of lobular breast cancer, from bedside to bench and back. The second most common breast cancer subtype, lobular breast cancer displays many unique molecular and clinical properties. Leaders in the field explore the molecular biology, pathology, risk factors, imaging, treatment and prognosis of this breast cancer.

Prof. Ulrich Lehmann. Hannover Medical School

  1. Review

    Lobular breast cancer series: imaging

    The limitations of mammography in the detection and evaluation of invasive lobular carcinoma (ILC) have long been recognized, presenting real clinical challenges in treatment planning for these tumors. However...

    Karen Johnson, Deba Sarma and E Shelley Hwang

    Breast Cancer Research 2015 17:94

    Published on: 11 July 2015

  2. Review

    Molecular drivers of lobular carcinoma in situ

    Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesi...

    Greg J. Logan, David J. Dabbs, Peter C. Lucas, Rachel C. Jankowitz, Daniel D. Brown, Beth Z. Clark, Steffi Oesterreich and Priscilla F. McAuliffe

    Breast Cancer Research 2015 17:76

    Published on: 4 June 2015

  3. Review

    Lobular breast cancer: molecular basis, mouse and cellular models

    Infiltrating lobular breast cancer (ILC) is the most common special breast cancer subtype. With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being confined almost exclusiv...

    Matthias Christgen and Patrick WB Derksen

    Breast Cancer Research 2015 17:16

    Published on: 8 February 2015

  4. Review

    Invasive lobular carcinoma of the breast: morphology, biomarkers and ’omics

    Invasive lobular carcinoma of the breast is the most common ‘special’ morphological subtype of breast cancer, comprising up to 15% of all cases. Tumours are generally of a good prognostic phenotype, being low ...

    Amy E McCart Reed, Jamie R Kutasovic, Sunil R Lakhani and Peter T Simpson

    Breast Cancer Research 2015 17:12

    Published on: 30 January 2015

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