Skip to main content

Modeling Johne's disease: from the inside out

© Ad P Koets et al.

This special issue of Veterinary Research is a compilation of work that explores and connects the dynamics of Mycobacterium avium ssp. paratuberculosis (MAP) - host interaction biology at multiple levels.

The aim of this work is to highlight the potential of mathematical modelling techniques in exploring knowledge gaps and alternative explanations for observations made in data from experimental and field studies, which may ultimately lead to a better understanding of this complex infection.

Edited by Prof Yrjo Grohn and Dr Ad Koets

Collection published: 19 June 2015

  1. Uptake of Mycobacterium avium subsp. paratuberculosis (MAP) by calves in the first days of life from colostrum, milk and faeces is regarded an important moment of transmission. The objective of this study was to ...

    Authors: Susanne WF Eisenberg, Victor PMG Rutten and Ad P Koets
    Citation: Veterinary Research 2015 46:70
  2. To better understand the mechanisms involved in the dynamics of Johne’s disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium avium ssp. paratuberculosis with a...

    Authors: Maia Martcheva, Suzanne Lenhart, Shigetoshi Eda, Don Klinkenberg, Eiichi Momotani and Judy Stabel
    Citation: Veterinary Research 2015 46:69
  3. Johne’s disease is an infectious gastrointestinal disease in ruminants caused by Mycobacterium avium subsp. paratuberculosis that causes diarrhea, emaciation, decreased milk production and eventually death. The d...

    Authors: Jessica Robins, Sarah Bogen, Auldon Francis, Annet Westhoek, Andrew Kanarek, Suzanne Lenhart and Shigetoshi Eda
    Citation: Veterinary Research 2015 46:68
  4. Many diseases are characterized by a long and varying sub-clinical period. Two main mechanisms can explain such periods: a slow progress toward disease or a sudden transition from a healthy state to a disease ...

    Authors: Yoram Louzoun, Rebecca Mitchell, Hilla Behar and Ynte Schukken
    Citation: Veterinary Research 2015 46:67
  5. The objective of this paper is to study shedding patterns of cows infected with Mycobacterium avium subsp. paratuberculosis (MAP). While multiple single farm studies of MAP dynamics were reported, there is not la...

    Authors: Rebecca M Mitchell, Ynte Schukken, Ad Koets, Maarten Weber, Douwe Bakker, Judy Stabel, Robert H Whitlock and Yoram Louzoun
    Citation: Veterinary Research 2015 46:66
  6. Longitudinal infection data on Mycobacterium avium subspecies paratuberculosis (MAP) was collected on three dairy farms in Northeastern United States during approximately 10 years. Precise data on animal chara...

    Authors: Ynte H Schukken, Robert H Whitlock, Dave Wolfgang, Yrjo Grohn, Annabelle Beaver, JoAnn VanKessel, Mike Zurakowski and Rebecca Mitchell
    Citation: Veterinary Research 2015 46:65
  7. Mycobacterium avium spp. paratuberculosis (MAP) causes a persistent infection and chronic inflammation of the gut in ruminants leading to bacterial shedding in feces in many infected animals. Alt...

    Authors: Vitaly V. Ganusov, Don Klinkenberg, Douwe Bakker and Ad P. Koets
    Citation: Veterinary Research 2015 46:62
  8. Johne’s disease or paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After ...

    Authors: Ad P Koets, Shigetoshi Eda and Srinand Sreevatsan
    Citation: Veterinary Research 2015 46:61