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Host-microbiota interaction in gastrointestinal and metabolic diseases

Lead guest editor: Dr. Julie Chan

The human gastrointestinal (GI) tract harbors a large amount of microorganisms, including bacteria, virus, archaea, and fungi, which are collectively defined as the GI microbiota. Presence of commensal bacteria in the GI tract was a long-known fact that did not draw much interest in the gastroenterological field over several decades, except in the cases of intestinal barrier dysfunction and septic complications. This neglected field was put into mainstream research in the post-human genome era, with accumulating evidence showing that GI microbiota is involved not only in the maintenance of physiological homeostasis but also in disease development throughout the body. The research in GI microbiota provides unforeseen molecular and genetic targets to understand the mechanisms of disease progression. However, teasing out the critical player(s) among this complex microbial ecosystem with genes 100-fold higher than those of the host would be a challenge for scientists to be used as novel strategies to treat human diseases. This special issue is dedicated to reviews that discuss various aspects of host-microbiota interaction in physiological states and in the context of human diseases such as gastrointestinal infection, inflammatory bowel disease, irritable bowel syndrome, colorectal cancers, and metabolic disorders.

  1. Content type: Review

    Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors leading to chronic inflammation in the intestin...

    Authors: Linda Chia-Hui Yu

    Citation: Journal of Biomedical Science 2018 25:79

    Published on:

  2. Content type: Review

    Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well...

    Authors: Matteo M Pusceddu and Melanie G Gareau

    Citation: Journal of Biomedical Science 2018 25:73

    Published on: