This special issue of Microbial Cell Factories covers the topic of 'Constructing 'intelligent' microbial cell factories' by dynamic and systems metabolic engineering approaches.
Edited by Prof Long Liu, Jiangnan University, China
This special issue of Microbial Cell Factories covers the topic of 'Constructing 'intelligent' microbial cell factories' by dynamic and systems metabolic engineering approaches.
Edited by Prof Long Liu, Jiangnan University, China
In industrial fermentation, pH fluctuation resulted from microbial metabolism influences the strain performance and the final production. The common way to control pH is adding acid or alkali after probe detec...
Citation: Microbial Cell Factories 2020 19:202
Cinnamyl alcohol is not only a kind of flavoring agent and fragrance, but also a versatile chemical applied in the production of various compounds. At present, the preparation of cinnamyl alcohol depends on pl...
Citation: Microbial Cell Factories 2020 19:163
Escherichia coli BL21 is arguably the most popular host for industrial production of proteins, and industrial fermentations are often plagued by phage infections. The CRISPR/Cas system is guided by a gRNA to clea...
Citation: Microbial Cell Factories 2020 19:136
Genome streamlining is a feasible strategy for constructing an optimum microbial chassis for synthetic biology applications. Genomic islands (GIs) are usually regarded as foreign DNA sequences, which can be ob...
Citation: Microbial Cell Factories 2020 19:70
Bacillus licheniformis 2709 is extensively applied as a host for the high-level production of heterologous proteins, but Bacillus cells often possess unfavorable wild-type properties, such as production of viscou...
Citation: Microbial Cell Factories 2020 19:45
Microbial cell factories are widely used in the production of acidic products such as organic acids and amino acids. However, the metabolic activity of microbial cells and their production efficiency are sever...
Citation: Microbial Cell Factories 2019 18:136
Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting materia...
Citation: Microbial Cell Factories 2019 18:132
Many fermented foods and beverages are produced through the action of complex microbial communities. Synthetic biology approaches offer the ability to genetically engineer these communities to improve the prop...
Citation: Microbial Cell Factories 2019 18:101
Microorganisms have long been used as chemical plant to convert simple substrates into complex molecules. Various metabolic pathways have been optimised over the past few decades, but the progresses were limit...
Citation: Microbial Cell Factories 2019 18:82
Non-conventional yeasts are playing important roles as cell factories for bioproduction of biofuels, food additives and proteins with outstanding natural characteristics. However, the precise genome editing is...
Citation: Microbial Cell Factories 2019 18:63
Nature has evolved exquisite sensing mechanisms to detect cellular and environmental signals surrounding living organisms. These biosensors have been widely used to sense small molecules, detect environmental ...
Citation: Microbial Cell Factories 2019 18:61
Naturally occurring carotenoids have been isolated and used as colorants, antioxidants, nutrients, etc. in many fields. There is an ever-growing demand for carotenoids production. To comfort this, microbial pr...
Citation: Microbial Cell Factories 2019 18:55
Metabolic engineering allows for the rewiring of basic metabolism to overproduce both native and non-native metabolites. Among these biomolecules, nutraceuticals have received considerable interest due to thei...
Citation: Microbial Cell Factories 2019 18:46
Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbia...
Citation: Microbial Cell Factories 2019 18:41
Streptomyces chattanoogensis L10 is the industrial producer of natamycin and has been proved a highly efficient host for diverse natural products. It has an enormous potential to be developed as a versatile cell ...
Citation: Microbial Cell Factories 2019 18:16
The shortage of food based feedstocks has been one of the stumbling blocks in industrial biomanufacturing. The acetone bioproduction from the traditional acetone–butanol–ethanol fermentation is limited by the ...
Citation: Microbial Cell Factories 2019 18:6
Glucosamine-6-phosphate N-acetyltransferase (GNA1) is the key enzyme that causes overproduction of N-acetylglucosamine in Bacillus subtilis. Previously, we increased GlcNAc production by promoting the expression ...
Citation: Microbial Cell Factories 2019 18:1