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Immunotherapy against cancer and immune disorders

Edited by Dr John T. Kung

This article collection, published in Journal of Biomedical Science, is dedicated to reviewing studies that use various different approaches that target activation of distinct immune cell pathways to therapeutically treat cancer and immune disorders.

This series of articles has not been sponsored. All articles have undergone the journal's standard peer review process overseen by the Guest Editor. The Guest Editor declares no competing interests.

  1. Review

    Cancer immunotherapies targeting the PD-1 signaling pathway

    Immunotherapy has recently emerged as the fourth pillar of cancer treatment, joining surgery, radiation, and chemotherapy. While early immunotherapies focused on accelerating T-cell activity, current immune-ch...

    Yoshiko Iwai, Junzo Hamanishi, Kenji Chamoto and Tasuku Honjo

    Journal of Biomedical Science 2017 24:26

    Published on: 4 April 2017

  2. Review

    Escape from IFN-γ-dependent immunosurveillance in tumorigenesis

    Immune interferon (IFN), also known as IFN-γ, promotes not only immunomodulation but also antimicrobial and anticancer activity. After IFN-γ binds to the complex of IFN-γ receptor (IFNGR) 1-IFNGR2 and subseque...

    Chiou-Feng Lin, Chih-Ming Lin, Kang-Yun Lee, Szu-Yuan Wu, Po-Hao Feng, Kuan-Yuan Chen, Hsiao-Chi Chuang, Chia-Ling Chen, Yu-Chih Wang, Po-Chun Tseng and Tsung-Ting Tsai

    Journal of Biomedical Science 2017 24:10

    Published on: 1 February 2017

  3. Review

    Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials

    Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomod...

    Li-Tzu Wang, Chiao-Hsuan Ting, Men-Luh Yen, Ko-Jiunn Liu, Huey-Kang Sytwu, Kenneth K. Wu and B. Linju Yen

    Journal of Biomedical Science 2016 23:76

    Published on: 4 November 2016

  4. Review

    Perspectives for therapeutic HPV vaccine development

    Human papillomavirus (HPV) infections and associated diseases remain a serious burden worldwide. It is now clear that HPV serves as the etiological factor and biologic carcinogen for HPV-associated lesions and...

    Andrew Yang, Emily Farmer, T. C. Wu and Chien-Fu Hung

    Journal of Biomedical Science 2016 23:75

    Published on: 4 November 2016

  5. Research

    A phase I clinical study of immunotherapy for advanced colorectal cancers using carcinoembryonic antigen-pulsed dendritic cells mixed with tetanus toxoid and subsequent IL-2 treatment

    To better evaluate and improve the efficacy of dendritic cell (DC)-based cancer immunotherapy, we conducted a clinical study of patients with advanced colorectal cancer using carcinoembryonic antigen (CEA)-pul...

    Ko-Jiunn Liu, Tsu-Yi Chao, Jang-Yang Chang, Ann-Lii Cheng, Hui-Ju Ch’ang, Woei-Yau Kao, Yu-Chen Wu, Wei-Lan Yu, Tsai-Rong Chung and Jacqueline Whang-Peng

    Journal of Biomedical Science 2016 23:64

    Published on: 24 August 2016