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Day of Immunology 2015

Immunology does not excite a media frenzy, yet it infiltrates and underpins so many scientific disciplines. Immunological research is diverse and the articles featured in this series exemplify perfectly its wide-ranging nature.

This is a retrospective collection, collated from previously published articles from BioMed Central journals.

  1. Acute ulcerative colitis is an inflammation-driven condition of the bowel. It hampers the general homeostasis of gut, resulting in decreased mucus production and epithelial cell renewal. Adiponectin (APN), an ...

    Authors: Kamaljeet Kaur, Arpit Saxena, Bianca Larsen, Samantha Truman, Nathan Biyani, Emma Fletcher, Manjeshwar Shrinath Baliga, Venkatesh Ponemone, Shweta Hegde, Anindya Chanda and Raja Fayad
    Citation: Journal of Inflammation 2015 12:35
  2. Whilst there have been a number of insights into the subsets of CD4+ T cells induced by pathogenic Bacillus anthracis infections in animal models, how these findings relate to responses generated in naturally inf...

    Authors: Rebecca J Ingram, Stephanie Ascough, Catherine J Reynolds, Gökhan Metan, Mehmet Doganay, Les Baillie, Diane E Williamson, John H Robinson, Bernard Maillere, Rosemary J Boyton and Daniel M Altmann
    Citation: Cell & Bioscience 2015 5:20
  3. Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection (CDI) that often fails standard antibiotic therapy. Despite its widespread recent use, however, littl...

    Authors: Alexa Weingarden, Antonio González, Yoshiki Vázquez-Baeza, Sophie Weiss, Gregory Humphry, Donna Berg-Lyons, Dan Knights, Tatsuya Unno, Aleh Bobr, Johnthomas Kang, Alexander Khoruts, Rob Knight and Michael J Sadowsky
    Citation: Microbiome 2015 3:10
  4. Development of a tumor is a very complex process, and invasion and metastasis of malignant tumors are hallmarks and are difficult problems to overcome. The tumor microenvironment plays an important role in con...

    Authors: Xue Yang, Dan-Dan Yu, Fei Yan, Ying-Ying Jing, Zhi-Peng Han, Kai Sun, Lei Liang, Jing Hou and Li-Xin Wei
    Citation: Cell & Bioscience 2015 5:14
  5. To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat.

    Authors: Min Shi, Fang Cui, Ai-Jing Liu, Hui-Jie Ma, Ming Cheng, Shu-Xia Song, Fang Yuan, De-Pei Li and Yi Zhang
    Citation: Journal of Inflammation 2015 12:23
  6. Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact th...

    Authors: Erika Jensen-Jarolim
    Citation: World Allergy Organization Journal 2015 8:60
  7. In the present study, we examined the inhibitory effects of a methanolic extract, dichloromethane fraction, water layer, and polyhydroxylated sterols (1–4) isolated from the Vietnamese starfish Protoreaster nodos...

    Authors: Nguyen Phuong Thao, Bui Thi Thuy Luyen, Jung Eun Koo, Sohyun Kim, Young Sang Koh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Phan Van Kiem, Young Ho Kim and Chau Van Minh
    Citation: Biological Research 2015 48:12
  8. Excessive and inappropriate immune responses are the hallmark of several autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn’s disease (CD) and ulcerative colitis (UC). A complex etiol...

    Authors: Jeremy S Schaefer, Taraq Attumi, Antone R Opekun, Bincy Abraham, Jason Hou, Harold Shelby, David Y Graham, Charles Streckfus and John R Klein
    Citation: BMC Immunology 2015 16:5
  9. Para-phenylenediamine (PPD) is the main allergen causing adverse reactions to hair dyes and a frequent cause of occupational-related skin sensitization among hairdressers and beauticians. The immunologic mecha...

    Authors: Valentina Bordignon, Francesca Palamara, Giorgia Altomonte, Isabella Sperduti, Mario Pietravalle, Claudia Cavallotti, Paola Cordiali-Fei, Maria Pia Fuggetta, Antonio Cristaudo and Fabrizio Ensoli
    Citation: BMC Immunology 2015 16:4
  10. Accumulating evidence suggests that neuroinflammation plays an important role in the progression of Parkinson’s disease (PD). Excessively activated microglia produce several pro-inflammatory enzymes and pro-in...

    Authors: Shou-Peng Fu, Jian-Fa Wang, Wen-Jing Xue, Hong-Mei Liu, Bing-run Liu, Ya-Long Zeng, Su-Nan Li, Bing-Xu Huang, Qing-Kang Lv, Wei Wang and Ju-Xiong Liu
    Citation: Journal of Neuroinflammation 2015 12:9
  11. Leptospirosis is a zoonotic spirochaetal illness that is endemic in many tropical countries. The research base on leptospirosis is not as strong as other tropical infections such as malaria. However, it is a l...

    Authors: Senaka Rajapakse, Chaturaka Rodrigo, Shiroma M Handunnetti and Sumadhya Deepika Fernando
    Citation: Annals of Clinical Microbiology and Antimicrobials 2015 14:2
  12. IL-6 is a pro-inflammatory cytokine which has many well-defined effects. Its synthesis and release from mononuclear cells of drug-sensitized patients was related before to in vitro drug-allergy diagnostics but ha...

    Authors: Joseph M Baló-Banga, Katalin Schweitzer, Susan Lakatos and Sándor Sipka
    Citation: World Allergy Organization Journal 2015 8:83
  13. Acquisition of the M1 or M2 phenotypes by microglia has been shown to occur during the development of pathological conditions, with M1 activation being widely involved in neurotoxicity in relation with the ana...

    Authors: Giovanna Pepe, Giorgia Calderazzi, Marcella De Maglie, Alessandro Maria Villa and Elisabetta Vegeto
    Citation: Journal of Neuroinflammation 2014 11:211
  14. Alzheimer’s disease (AD) is a complex disease resulting in neurodegeneration and cognitive impairment. Investigations on environmental factors implicated in AD are scarce and the etiology of the disease remain...

    Authors: Federico Licastro, Ilaria Carbone, Elena Raschi and Elisa Porcellini
    Citation: Immunity & Ageing 2014 11:22
  15. The reproducible nature of HIV-1 escape from HLA-restricted CD8+ T-cell responses allows the identification of HLA-associated viral polymorphisms “at the population level” – that is, via analysis of cross-sect...

    Authors: Eric Martin, Jonathan M Carlson, Anh Q Le, Denis R Chopera, Rachel McGovern, Manal A Rahman, Carmond Ng, Heiko Jessen, Anthony D Kelleher, Martin Markowitz, Todd M Allen, M-J Milloy, Mary Carrington, Mark A Wainberg and Zabrina L Brumme
    Citation: Retrovirology 2014 11:64
  16. The effect of the chronic stress of bereavement on immunity is poorly understood. Previous studies have demonstrated negative effects on immunity in older adults, and those who report higher depressive symptom...

    Authors: Ana Vitlic, Riyad Khanfer, Janet M Lord, Douglas Carroll and Anna C Phillips
    Citation: Immunity & Ageing 2014 11:13
  17. Activation of nuclear factor-kappa B (NF- κ B) as a mechanism of host defense against infection and stress is the central mediator of inflammatory responses. A normal (acute) inflammatory response is activated on...

    Authors: Srabani Pal, Ashish Bhattacharjee, Asif Ali, Narayan C Mandal, Subhash C Mandal and Mahadeb Pal
    Citation: Journal of Inflammation 2014 11:23
  18. The imbalance between Th17 and Treg cells has been studied in various diseases including allergic asthma but their roles have not been fully understood in the development of the late phase asthmatic response.

    Authors: Amrit Singh, Masatsugu Yamamoto, Jian Ruan, Jung Young Choi, Gail M Gauvreau, Sven Olek, Ulrich Hoffmueller, Christopher Carlsten, J Mark FitzGerald, Louis-Philippe Boulet, Paul M O'Byrne and Scott J Tebbutt
    Citation: Allergy, Asthma & Clinical Immunology 2014 10:32
  19. Allergic sensitization is the outcome of a complex interplay between the allergen and the host in a given environmental context. The first barrier encountered by an allergen on its way to sensitization is the ...

    Authors: Ronald van Ree, Lone Hummelshøj, Maud Plantinga, Lars K Poulsen and Emily Swindle
    Citation: Clinical and Translational Allergy 2014 4:12
  20. It is now known that clinically derived viruses are most commonly R5 tropic with very low infectivity in macrophages. As these viruses utilize CD4 inefficiently, defective entry has been assumed to be the domi...

    Authors: Petra Mlcochova, Sarah A Watters, Greg J Towers, Mahdad Noursadeghi and Ravindra K Gupta
    Citation: Retrovirology 2014 11:25
  21. Allergy to cow’s milk protein (CMP) may cause gastrointestinal (GI) symptoms in the absence of CMP specific IgE. The immunological mechanisms involved in such disease are not fully understood. Therefore we exa...

    Authors: Laura Merras-Salmio, Kaija-Leena Kolho, Anna S Pelkonen, Mikael Kuitunen, Mika J Mäkelä and Erkki Savilahti
    Citation: Clinical and Translational Allergy 2014 4:8
  22. Up to 30% of patients with food allergies have clinical reactivity to more than one food allergen. Although there is currently no cure, oral immunotherapy (OIT) is under investigation. Pilot data have shown th...

    Authors: Philippe Bégin, Tina Dominguez, Shruti P Wilson, Liane Bacal, Anjuli Mehrotra, Bethany Kausch, Anthony Trela, Morvarid Tavassoli, Elisabeth Hoyte, Gerri O’Riordan, Alanna Blakemore, Scott Seki, Robert G Hamilton and Kari C Nadeau
    Citation: Allergy, Asthma & Clinical Immunology 2014 10:7
  23. Low-grade inflammatory state causes the development of the principal chronic-degenerative pathologies related with ageing. Consequently, it is required a better comprehension of the physiologic origins and the...

    Authors: Anna Maria Berghella, Ida Contasta, Giuseppe Marulli, Carlo D’Innocenzo, Ferdinando Garofalo, Francesca Gizzi, Marco Bartolomucci, Giacomo Laglia, Marisa Valeri, Mario Gizzi, Mauro Friscioni, Mario Barone, Tiziana Del Beato, Enzo Secinaro and Patrizia Pellegrini
    Citation: Immunity & Ageing 2014 11:3
  24. Chronic spontaneous urticaria (CSU) is an immune-inflammatory disease, characterized by acute phase response (APR) and immune activation. There has been increasing evidence showing that vitamin D deficiency/in...

    Authors: Alicja Grzanka, Edyta Machura, Bogdan Mazur, Maciej Misiolek, Jerzy Jochem, Jacek Kasperski and Alicja Kasperska-Zajac
    Citation: Journal of Inflammation 2014 11:2
  25. Resistance to antibiotics has increased dramatically over the past few years and has now reached a level that places future patients in real danger. Microorganisms such as Escherichia coli and Klebsiella pneumoni...

    Authors: Jean Carlet, Vincent Jarlier, Stephan Harbarth, Andreas Voss, Herman Goossens and Didier Pittet
    Citation: Antimicrobial Resistance and Infection Control 2012 1:11