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Immunogenomics in health and disease

Guest editor: Robert Holt

Our understanding of how the human immune system functions in health and disease is broadening as never before due to the intersection of immunology with high-throughput technologies, and the emergence of the immunogenomics field. To capture the advances in this exciting area Genome Medicine is pleased to present a special issue focused on Immunogenomics in health and disease.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest editor declares no competing interests.

  1. Content type: Research

    The heat shock transcriptional response is essential to effective cellular function under stress. This is a highly heritable trait but the nature and extent of inter-individual variation in heat shock response...

    Authors: Peter Humburg, Narelle Maugeri, Wanseon Lee, Bert Mohr and Julian C. Knight

    Citation: Genome Medicine 2016 8:87

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  2. Content type: Method

    Accurate characterization of the repertoire of the T-cell receptor (TCR) alpha and beta chains is critical to understanding adaptive immunity. Such characterization has many applications across such fields as ...

    Authors: David Redmond, Asaf Poran and Olivier Elemento

    Citation: Genome Medicine 2016 8:80

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  3. Content type: Research

    IL-4-driven alternative macrophage activation and proliferation are characteristic features of both antihelminthic immune responses and wound healing in contrast to classical macrophage activation, which prima...

    Authors: Zsolt Czimmerer, Tamas Varga, Mate Kiss, Cesaré Ovando Vázquez, Quang Minh Doan-Xuan, Dominik Rückerl, Sudhir Gopal Tattikota, Xin Yan, Zsuzsanna S. Nagy, Bence Daniel, Szilard Poliska, Attila Horvath, Gergely Nagy, Eva Varallyay, Matthew N. Poy, Judith E. Allen…

    Citation: Genome Medicine 2016 8:63

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  4. Content type: Research

    The study of human B cell response to dengue virus (DENV) infection is critical to understand serotype-specific protection and the cross-reactive sub-neutralizing response. Whereas the first is beneficial and ...

    Authors: Elizabeth Ernestina Godoy-Lozano, Juan Téllez-Sosa, Gilberto Sánchez-González, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Aarón Salinas-Rodríguez, Bernardo Cortina-Ceballos, Héctor Vivanco-Cid, Karina Hernández-Flores, Jennifer M. Pfaff, Kristen M. Kahle, Benjamin J. Doranz, Rosa Elena Gómez-Barreto, Humberto Valdovinos-Torres, Irma López-Martínez, Mario H. Rodriguez…

    Citation: Genome Medicine 2016 8:23

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  5. Content type: Method

    Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and res...

    Authors: Jasreet Hundal, Beatriz M. Carreno, Allegra A. Petti, Gerald P. Linette, Obi L. Griffith, Elaine R. Mardis and Malachi Griffith

    Citation: Genome Medicine 2016 8:11

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  6. Content type: Method

    String-of-beads polypeptides allow convenient delivery of epitope-based vaccines. The success of a polypeptide relies on efficient processing: constituent epitopes need to be recovered while avoiding neo-epito...

    Authors: Benjamin Schubert and Oliver Kohlbacher

    Citation: Genome Medicine 2016 8:9

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  7. Content type: Research

    Hemophagocytic lymphohistiocytosis (HLH) is a rapid-onset, potentially fatal hyperinflammatory syndrome. A prompt molecular diagnosis is crucial for appropriate clinical management. Here, we validated and pros...

    Authors: Bianca Tesi, Kristina Lagerstedt-Robinson, Samuel C. C. Chiang, Eya Ben Bdira, Miguel Abboud, Burcu Belen, Omer Devecioglu, Zehra Fadoo, Allen E. J. Yeoh, Hans Christian Erichsen, Merja Möttönen, Himmet Haluk Akar, Johanna Hästbacka, Zuhre Kaya, Susana Nunes, Turkan Patiroglu…

    Citation: Genome Medicine 2015 7:130

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  8. Content type: Research

    Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication followin...

    Authors: Dirk S. Paul, Allison Jones, Rob S. Sellar, Neema P. Mayor, Andrew Feber, Amy P. Webster, Neuza Afonso, Ruhena Sergeant, Richard M. Szydlo, Jane F. Apperley, Martin Widschwendter, Stephen Mackinnon, Steven G. E. Marsh, J. Alejandro Madrigal, Vardhman K. Rakyan, Karl S. Peggs…

    Citation: Genome Medicine 2015 7:128

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  9. Content type: Method

    Deep sequencing of recombined T cell receptor (TCR) genes and transcripts has provided a view of T cell repertoire diversity at an unprecedented resolution. Beyond profiling peripheral blood, analysis of tissu...

    Authors: Scott D. Brown, Lisa A. Raeburn and Robert A. Holt

    Citation: Genome Medicine 2015 7:125

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  10. Content type: Research

    Despite the potential to produce antibodies that can neutralize different virus (heterotypic neutralization), there is no knowledge of why vaccination against influenza induces protection predominantly against...

    Authors: Bernardo Cortina-Ceballos, Elizabeth Ernestina Godoy-Lozano, Juan Téllez-Sosa, Marbella Ovilla-Muñoz, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Rosa Elena Gómez-Barreto, Humberto Valdovinos-Torres, Irma López-Martínez, Rodrigo Aparicio-Antonio, Mario H. Rodríguez and Jesús Martínez-Barnetche

    Citation: Genome Medicine 2015 7:124

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  11. Content type: Research

    The adaptive immune system generates a remarkable range of antigen-specific T-cell receptors (TCRs), allowing the recognition of a diverse set of antigens. Most of this diversity is encoded in the complementar...

    Authors: Jared Dean, Ryan O. Emerson, Marissa Vignali, Anna M. Sherwood, Mark J. Rieder, Christopher S. Carlson and Harlan S. Robins

    Citation: Genome Medicine 2015 7:123

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  12. Content type: Research

    Activation and differentiation of T-helper (Th) cells into Th1 and Th2 types is a complex process orchestrated by distinct gene activation programs engaging a number of genes. This process is crucial for a rob...

    Authors: Kartiek Kanduri, Subhash Tripathi, Antti Larjo, Henrik Mannerström, Ubaid Ullah, Riikka Lund, R. David Hawkins, Bing Ren, Harri Lähdesmäki and Riitta Lahesmaa

    Citation: Genome Medicine 2015 7:122

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  13. Content type: Database

    Human cancer cell lines are an important resource for research and drug development. However, the available annotations of cell lines are sparse, incomplete, and distributed in multiple repositories. Re-analyz...

    Authors: Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin and John C. Castle

    Citation: Genome Medicine 2015 7:118

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  14. Content type: Research

    Gene profiling of diffuse large B cell lymphoma (DLBCL) has revealed broad gene expression deregulation compared to normal B cells. While many studies have interrogated well known and annotated genes in DLBCL,...

    Authors: Akanksha Verma, Yanwen Jiang, Wei Du, Lauren Fairchild, Ari Melnick and Olivier Elemento

    Citation: Genome Medicine 2015 7:110

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  15. Content type: Research

    Cancers adapt to immune-surveillance through evasion. Immune responses against carcinoma and melanoma converge on cytotoxic effectors and IFNγ-STAT1-IRF1 signalling. Local IFN-driven immune checkpoint expressi...

    Authors: Matthew A. Care, David R. Westhead and Reuben M. Tooze

    Citation: Genome Medicine 2015 7:96

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  16. Content type: Research

    The prevalence of allergic diseases are increasing worldwide, emphasizing the need to elucidate their pathogeneses. The aims of this study were to use a two-stage design to identify DNA methylation levels at c...

    Authors: Todd M. Everson, Genevieve Lyons, Hongmei Zhang, Nelís Soto-Ramírez, Gabrielle A. Lockett, Veeresh K. Patil, Simon K. Merid, Cilla Sӧderhӓll, Erik Melén, John W. Holloway, S. Hasan Arshad and Wilfried Karmaus

    Citation: Genome Medicine 2015 7:89

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