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Intraocular Lens Technologies

Guest Editors:
Andreas F. Borkenstein: Private Practice Borkenstein & Borkenstein, Austria
Ramin Khoramnia: University of Heidelberg, Germany
Nambi Nallasamy: University of Michigan, USA
Ibrahim Toprak:  Pamukkale University, Turkey 

This BMC Ophthalmology collection collates original research articles and review articles regarding New Intraocular Lens Technologies with a special focus on presbyopia correcting IOLs, new and innovative EDoF and enhanced monofocal intraocular lenses.

Meet the Guest Editors

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Andreas F. Borkenstein: Private Practice Borkenstein & Borkenstein, Austria

Andreas F. Borkenstein  is an Austrian ophthalmologist specializing in cataract and refractive surgery. In addition, he collaborates scientifically with international research groups: Focuses include optical bench analysis of intraocular lenses, evaluating lens designs, description and analysis of iatrogenically created defects in IOLs (YAG-pits) or evaluation of new viscoelastics (OVDs). He also regularly participates in multicentre clinical evaluations of new premium lenses.

Ramin Khoramnia: University of Heidelberg, Germany

Ramin Khoramnia is an Associate Professor, Senior Physician and high-volume surgeon in the Department of Ophthalmology, University of Heidelberg in Germany. He is head of the department for refractive and experimental surgery. Furthermore, he is doing research in the David J. Apple International Laboratory for Ocular Pathology, where his work is mainly focused on biomaterials, drugs, and intraocular lens optics. Prof. Dr. Khoramnia is a key opinion leader (KOL) and well-known expert in the field of presbyopia treatment, cataract and refractive surgery (including different kinds of premium intraocular lenses and surgical devices), and retinal diseases (especially intravitreal medication for macular diseases).  His clinical experience and research interests include presbyopia treatment, cataract surgery (biomaterials, intraocular lenses, optics, and ophthalmic viscoelastic devices), refractive laser technology and surgery, diagnostic tools, retinal diseases, corneal and uveitic diseases.

Nambi Nallasamy:  University of Michigan, USA

Dr Nallasamy is an Assistant Professor of Ophthalmology and Visual Sciences as well as an Assistant Professor of Computational Medicine and Bioinformatics at University of Michigan. A graduate of Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology, Dr Nallasamy completed his ophthalmology residency at Duke University Eye Center, followed by a cornea, external disease, and refractive surgery fellowship at Bascom Palmer Eye Institute. Dr Nallasamy combines a busy clinical practice with research in the development and application of machine learning techniques to improve ophthalmic diagnostics and surgical treatment planning. He is actively involved in the clinical and surgical training of ophthalmology residents and cornea fellows, as well as the training of masters and PhD students in the University of Michigan Department of Computational Medicine and Bioinformatics. 

Ibrahim Toprak:  Pamukkale University, Turkey

IIbrahim Toppak is an Associate Professor of ophthalmology at the Pamukkale University, Faculty of Medicine, Denizli, Turkey. Cornea, Cataract & Refractive surgery are my primary areas of interest.


About the collection

Approximately 35 million cataract surgeries are performed annually worldwide. A large number of implantable lenses are available, and surgeons can choose from a variety of intraocular lenses (IOLs). In order to provide the best possible care and to allow patients to live a spectacle-independent life, it is very important for the clinical ophthalmologist and for the surgeon to have a sound knowledge of the technology and optical principles in order to select the best possible option in the individual case.

To achieve a sustained good functional outcome after implantation of an intraocular lens (IOL), two factors in particular are of major importance, namely the optics and the material of the IOL. Advancements in surgical techniques have changed the spectrum of complications and reasons for explantation when using IOLs.

On the flipside, reports of material opacification have increased in the literature and calcifications in hydrophilic IOLs have been reported. For hydrophobic IOLs, the development of "glistenings" has been described. 

This Special Collection aimed to collate original research articles and review articles regarding New Intraocular Lens Technologies with a special focus on presbyopia correcting IOLs, new and innovative EDoF and enhanced monofocal intraocular lenses. We were looking for research, both from laboratory and clinical studies including new findings in the field of optical and material properties of IOLs. We also accepted high-quality systematic reviews and meta-analyses in this field.

Potential topics include but are not limited to the following:

  • Extended Depth of Focus (EDOF) IOLs and enhanced monofocal IOLs
  • Multifocal IOLs
  • “Modern” monofocal IOLs (also named „monofocal plus” or monoEDOF IOLs)
  • IOL power calculation
  • Experimental and laboratory research of new IOL designs
  • Analysis of optical principles and evaluation of optical quality
  • Clinical studies presenting long-term results focussing on optical quality and side effects 
  • IOL opacification or calcification
  • Undesirable effects like dysphotopsia (halo and glare) or glistenings 
  • Optical bench measurements
  • IOL material interaction
  • Surface coating

(i.e. Image credit: Peter Adams / Getty)

  1. Postoperative performance, including best corrected distance visual acuity (BCDVA) and optical metrics (from the OQAS and iTrace devices), was compared among 4 different intraocular lenses (IOLs).

    Authors: Shuanglin Guo, Hao Huang, Bowen Li, Mansha Huang, Lu Gao, Jingyi Chen, Yuying Zeng, Ye Yang, Lin Liu, Lu Cheng, Siyang Yao and Hao Cheng
    Citation: BMC Ophthalmology 2024 24:198
  2. Late-onset capsule block syndrome (CBS) is a rare complication of cataract phacoemulsification and the implantation of a posterior chamber intraocular lens (PCIOL), which manifests six months to years after su...

    Authors: Ying-Hua Du, Xiao-Fang Liang, Kazuyuki Hirooka, Hui-Ka Xia and Zhi-Yang Jia
    Citation: BMC Ophthalmology 2024 24:53
  3. Sutureless scleral fixed intraocular lens implantation (SF-IOL) has become one of the mainstream schemes in clinical treatment of aphakic eyes because of its advantages, such as avoiding dislocation of intraoc...

    Authors: Zhao Liu, Qian Xie, XingWang Chen, Bing Xie and ShanJun Cai
    Citation: BMC Ophthalmology 2023 23:493
  4. This study aims to identify the relationship between iris -ciliary angle (ICA) and the vault. Additionally, we also seek to investigate the chain mediating effects of the ICL haptic related factors on this rel...

    Authors: Weina Tan, Zheng Wang, Qingyan Zeng, Xiaohua Lei, Chao Pan, Bao Shu, Lina Jin and Qian Chen
    Citation: BMC Ophthalmology 2023 23:403
  5. Hydrophilic intraocular lens opacification is a rare complication due to calcification. With current new surgical techniques, including lamellar endothelial keratoplasty and vitrectomies, this irreversible com...

    Authors: Panos S. Gartaganis, Panagiota D. Natsi, Sotirios P. Gartaganis, Petros G. Koutsoukos, Evangelos Manousakis and Efthymios Karmiris
    Citation: BMC Ophthalmology 2023 23:359
  6. To determine the efficacy of cataract surgeries in blindness prevention programs in Chongqing.

    Authors: Yongguo Xiang, Xiaoqin Wang, Xiaochuan Cao, Fang Wei, Yu Chen, Jianchuan Ran, Zhengqin Long, Qunwu Tan, Zhenying Lai, Li Liu, Desheng Zhao, Liang Xiong, Bin Tang, Wenjuan Wan and Ke Hu
    Citation: BMC Ophthalmology 2023 23:353
  7. To evaluate if total keratometry (TK) is better than standard keratometry (K) for predicting an accurate intraocular lens (IOL) refractive outcome in virgin eyes using four IOL power calculation formulas.

    Authors: He Zhao, Xu Chen, Bo Liu, Xi Liu and Yong Liu
    Citation: BMC Ophthalmology 2023 23:346
  8. To evaluate anterior segment structural alterations after implantable collamer lens (ICL) implantation in myopic patients using swept-source quantitative optical coherence tomography (SS-OCT).

    Authors: Chuhao Tang, Tong Sun, Zhengze Sun, Hongyu Duan, Yilin Liu, Lu Zhao, Wenlong Li, Linbo Bian and Hong Qi
    Citation: BMC Ophthalmology 2023 23:193
  9. Precise ocular measurements are fundamental for achieving excellent target refraction following both cataract surgery and refractive lens exchange. Biometry devices with swept-source optical coherence tomograp...

    Authors: Piotr Kanclerz, Idan Hecht and Raimo Tuuminen
    Citation: BMC Ophthalmology 2023 23:182
  10. To determine the indications and surgical outcomes of intraocular lens (IOL) exchange in pseudophakic patients at Labbafinejad Tertiary Referral Center between 2014 and 2019.

    Authors: Mohammadreza Jafarinasab, Masomeh Kalantarion, Sadid Hooshmandi, Kiana Hassanpour, Danial Najdi, Bahareh Kheiri and Hamideh Sabbaghi
    Citation: BMC Ophthalmology 2023 23:127
  11. A new generation of enhanced monofocal IOLs has been introduced to slightly increase the depth of focus as compared to standard monofocal IOLs. The purpose of this study is to evaluate the effect of pupil size...

    Authors: Aixa Alarcon, Carmen Canovas, Bram Koopman, Milind V Pande, Douglas D Koch and Patricia Piers
    Citation: BMC Ophthalmology 2023 23:112
  12. New intraocular lenses (IOLs) have emerged since the originally coined monofocal and multifocal IOLs. The extended depth of focus (EDoF) and enhanced monofocal IOLs (mono-EDoF) that have appeared in the last d...

    Authors: Joaquín Fernández, Carlos Rocha-de-Lossada, Francisco Zamorano-Martín, Marina Rodríguez-Calvo-de-Mora and Manuel Rodríguez-Vallejo
    Citation: BMC Ophthalmology 2023 23:101
  13. To compare the intraocular lens (IOL) tilt and decentration and visual outcomes of transscleral sutured IOL fixation and sutureless flanged IOL fixation. To investigate the influence of IOL tilt and decentrati...

    Authors: Ying Cui, Qiyan Li, Xiangyu Shi and Dan Zhou
    Citation: BMC Ophthalmology 2023 23:23
  14. Neodymium:yttrium aluminum garnet (Nd:YAG) laser capsulotomy is a well-accepted, safe, and effective measure in the treatment of posterior capsule opacification. However, iatrogenic intraocular lens damage is ...

    Authors: A. F. Borkenstein, E. M. Borkenstein, P. Omidi and A. Langenbucher
    Citation: BMC Ophthalmology 2022 22:494