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Immunotherapy in type 1 diabetes

Editor:

Sérgio Vencio, MD, PhD, MSc, Institute of Pharmaceutical Sciences (ICF), Brazil
Marcello Casaccia Bertoluci, MD, PhD, Universidade Federal do Rio Grande do Sul, Brazil

Submission Status: Closed


This collection is no longer accepting submissions.


Diabetology & Metabolic Syndrome is calling for submissions to our collection on Immunotherapy in type 1 diabetes. Type 1 diabetes is an autoimmune disease and characterize by the cell death of islet β-cells by patient’s immune system. Although discovery of insulin and its administration remained as only possible therapy, risk of long-term effects on eye and kidney along with chances of mortality remains concerning. Unfortunately, most data regarding immunotherapy are at the experimental level and only pre-clinical trial results are available. More research is needed to conclude its safety and efficacy in larger populations. However, in future, immunotherapy remains as the hope for treating Type 1 diabetes without insulin administration.

Image credit: © Gilnature / Getty Images / iStock

  1. Mesenchymal stem cell infusion and vitamin D supplementation may have immunomodulatory actions that could prolong the preservation of residual insulin secretion in patients with type 1 diabetes (T1D). Interven...

    Authors: Isabella Sued Leão, Joana Rodrigues Dantas, Débora Baptista Araújo, Maria Eduarda Nascimento Ramos, Karina Ribeiro Silva, Leandra S. Batista, Maria de Fátima Carvalho Pereira, Ronir Raggio Luiz, César Cláudio da Silva, Angelo Maiolino, Carmen Lúcia Kuniyoshi Rebelatto, Débora Regina Daga, Alexandra Cristina Senegaglia, Paulo Roberto Slud Brofman, José Egídio Paulo de Oliveira, Lenita Zajdenverg…
    Citation: Diabetology & Metabolic Syndrome 2024 16:114
  2. Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca2+ pathways have been id...

    Authors: Sofi Imtiyaz Ali, Ahmed M. E. Elkhalifa, Showkat Ul Nabi, Faisal Sualeh Hayyat, Mehak Nazar, Syed Taifa, Rabia Rakhshan, Iqra Hussain Shah, Muzaffer Shaheen, Imtiyaz Ahmad Wani, Umar Muzaffer, Ovais Shabir Shah, Dil Mohammad Makhdoomi, Elsadig Mohamed Ahmed, Khalil A. A. Khalil, Elsharif.A. Bazie…
    Citation: Diabetology & Metabolic Syndrome 2024 16:110
  3. Regulatory T cells (Tregs) are involved in the maintenance of immune homeostasis and immune regulation. Clinical trials on the adoptive transfer of Tregs have been ongoing for > 10 years. However, many unresol...

    Authors: Yuanjie Bi, Ran Kong, Yani Peng, Donghua Cai, Yu Zhang, Fan Yang, Xia Li, Wen Deng, Fang Liu, Binbin He, Chuqing Cao, Chao Deng, Xiaohan Tang, Li Fan, Haibo Yu and Zhiguang Zhou
    Citation: Diabetology & Metabolic Syndrome 2024 16:71

About the collection

Diabetology & Metabolic Syndrome is calling for submissions to our collection on Immunotherapy in type 1 diabetes. Type 1 diabetes is an autoimmune disease and characterize by the cell death of islet β-cells by patient’s immune system. Once these cells are destroyed, no regeneration occurs, leading to high blood glucose level. Although discovery of insulin and its administration remained as only possible therapy, risk of long-term effects on eye and kidney along with chances of mortality remains concerning. One possible cure is the immunotherapy after the early screening and detection of type 1 diabetes before the onset of the disease, when a reasonable amount of the cells is still actively producing insulin. Immunotherapy for type 1 diabetes includes islet cell transplantation and subsequent administration of immune modulating drugs, antigen specific therapies and thus reduction of body’s immune response or enhancing tolerance to β-cell antigens, in most of the cases generating concerning side effects.  Unfortunately, most data regarding immunotherapy are at the experimental level and only pre-clinical trial results are available. More research is needed to conclude its safety and efficacy in larger populations. However, in future, immunotherapy remains as the hope for treating Type 1 diabetes without insulin administration.

This collection thus encourages manuscript (original articles, reviews, clinical interventions, case study) addressing recent advances in the overall theme of immunotherapy in type 1 diabetes and the respective outcomes.

Submission Guidelines

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This Collection welcomes submission of Research Articles, Data Notes, Case Reports, Study Protocols, and Database Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a collection, please select "Immunotherapy in type 1 diabetes" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.