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Immunity and inflammation in Cardiovascular Disorders

Guest Editors:

Vennela Boyalla: University of Manchester, UK
Enrique Gallego-Colon: Escuela Naval Militar (E.N.M.), Spain
Michael Spartalis: National and Kapodistrian University of Athens, Greece

BMC Cardiovascular Disorders has published this Collection on Immunity and inflammation in Cardiovascular Disorders. Despite great advances in the diagnosis and treatment of cardiovascular diseases (CVD), it remains one of the leading causes of morbidity and mortality worldwide. Recent evidence indicates immuno-inflammatory activation may play a pivotal role in pathogenic mechanisms of CVD, opening novel pharmacological opportunities. Local and systemic dysregulation of the immune system and inflammatory pathways impact local myocardial tissue that may play a role in the pathophysiology of many CVDs, including heart failure, myocardial infarction, pericardial disease, cardiomyopathies, atherosclerosis, and rhythm disorders.

Meet the Guest Editors

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Vennela BoyallaUniversity of Manchester, UK

Dr Vennela Boyalla is an academic cardiology trainee in Manchester (United Kingdom). After graduating MBChB (MD) from University of Manchester, Vennela was appointed as an Academic Foundation Programme working on telemedicine trials in heart failure. She then gained Membership to the Royal College of Physicians (MRPC) during her internal medicine training. Following, Vennela worked as a PhD research fellow at Imperial College London running a multi-centre randomised controlled trial comparing ablation strategies in non-paroxysmal atrial fibrillation, which was funded by National Institute of Health Research (NIHR). She is now pursuing research interests in treating inflammation and obesity to help manage atrial fibrillation, while training in clinical cardiology. She has been appointed as Women in Cardiology trainee representative for Northwest England in the United Kingdom. During her spare time, she loves politics and cooking.

Enrique Gallego-ColonEscuela Naval Militar (E.N.M.), Spain

Dr Enrique J. Gallego-Colon is a clinician and translational researcher in cardiology at Escuela Naval Militar (E.N.M.) and Associate Professor at Escuela Militar de Sanidad (EMISAN). For his PhD, he was awarded with a Marie Curie Early Stage Researcher, EU-FP7 to perform his Phd studies at the Imperial College London were he joined the cardiac regeneration group lead by Prof. Nadia Rosenthal. His main research interest is on cardiovascular health as well as the disease process development (atherosclerosis, stroke and myocardial infarction) with particular emphasis to the molecular mechanisms of cardiovascular immunity and regeneration. Especially interested on investigating novel therapeutic approaches to achieve functional recovery through enhancing the reparative processes of the of the damaged myocardium and reversal of adverse heart remodeling. His research overlaps with these clinical areas but also covers broad aspects of medicine and innovation. He is member of the European Society of Cardiology as well as the American Society of Cardiology.

Michael Spartalis: National and Kapodistrian University of Athens, Greece

Dr. Michael Spartalis is an Attending Cardiologist, Certified Electrophysiology Specialist, and Certified Cardiac Device Specialist. Currently, an Academic Scholar at the 3rd Department of Cardiology, National and Kapodistrian University of Athens, Clinical Scholar at Harvard Medical School, and an Expert on medical devices at the European Commission. His work focuses on cardiovascular medicine, cardiac electrophysiology, device therapy, and antiplatelet therapy. He currently works on evidence regarding the beneficial therapy with colchicine for atherosclerosis via anti-inflammation and decrease in hypertriglyceridemia. He holds an MD and a PhD from National and Kapodistrian University of Athens, Medical School, a MSc in Thrombosis, Hemorrhage and Transfusion medicine from National and Kapodistrian University of Athens, Medical School, a MHCM from Conservatoire National des Arts et Métiers, and a Master in Interventional Electrophysiology from Università Vita-Salute San Raffaele. Most recently, he completed the Oxford's Leadership Program.

About the collection

This article collection of BMC Cardiovascular Disorders collected articles describing research exploring the molecular mechanisms underlying CVD, studies with translational potential, as well as pre-clinical and clinical investigations. 

Topics of interest included, but were not limited to:

● Immunity and inflammation in Atherosclerosis
● Inflammation and Atrial Fibrillation
● Immunity and inflammation in Acute Coronary Syndrome and Myocardial Infarction
● Immunity and inflammation in Hypertension
● Immunity and inflammation in Metabolic syndrome
● Immunity and inflammation in Heart failure
● Immunity and inflammation in Valvulopathies
● Immunity and inflammation in Myocarditis and Pericarditis
● Immunity and inflammation in Peripheral artery disease (PAD)
● Pharmacological interventions

  1. In the current systematic review and meta-analysis, we aim to analyze the existing literature to evaluate the role of inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lympho...

    Authors: Yuexia Zhao, Arshin Ghaedi, Pouria Azami, Seyed Ali Nabipoorashrafi, Hamed Bazrafshan Drissi, Maryam Amin Dezfouli, Shirin Sarejloo, Brandon Lucke-Wold, John Cerillo, Monireh Khanzadeh, Negar Jafari and Shokoufeh Khanzadeh
    Citation: BMC Cardiovascular Disorders 2024 24:276

    The Correction to this article has been published in BMC Cardiovascular Disorders 2024 24:296

  2. Acute myocardial infarction (AMI) is indeed a significant cause of mortality and morbidity in individuals with coronary heart disease. Ferroptosis, an iron-dependent cell death, is characterized by the accumul...

    Authors: Xinyu Wu, Jingru Li, Shengjie Chai, Chaguo Li, Si Lu, Suli Bao, Shuai Yu, Hao Guo, Jie He, Yunzhu Peng, Huang Sun and Luqiao Wang
    Citation: BMC Cardiovascular Disorders 2024 24:123
  3. Predicting the prognosis of primary percutaneous coronary intervention(PPCI) in ST-segment elevation myocardial infarction (STEMI) patients in the perioperative period is of great clinical significance. The in...

    Authors: Ailin Liu, Na Sun, Feiyu Gao, Xiaotong Wang, Hong Zhu and Defeng Pan
    Citation: BMC Cardiovascular Disorders 2024 24:67
  4. Many studies have found that miR-26a-5p plays an essential role in the progression of pathological cardiac hypertrophy, however, there is still no evidence on whether miR-26a-5p is related to the activation of...

    Authors: Li-qun Tang, Wei Wang, Qi-feng Tang and Ling-ling Wang
    Citation: BMC Cardiovascular Disorders 2024 24:18
  5. Endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilatory and vasoconstrictive effects and may play an important role in the development of heart failure. An increasing ...

    Authors: Peng Yang, Yujing Wu, Fangfei Li, Jiangfeng Tang, Zhenzhong Zheng and Qingshan Tian
    Citation: BMC Cardiovascular Disorders 2024 24:11
  6. Optimal medical therapy (OMT) for uncomplicated type B aortic dissection (uTBAD) provides excellent short-term outcomes during follow up; however, its long-term therapeutic effectiveness is unsatisfactory. Thi...

    Authors: Ruirong Chen, Sheng Su, Changjin Wang, Yuan Liu, Wenhui Huang, Songyuan Luo, Fan Yang and Jianfang Luo
    Citation: BMC Cardiovascular Disorders 2024 24:7
  7. Inflammatory markers may provide insights into the underlying mechanisms of slow coronary flow (SCF), including subclinical atherosclerosis and endothelial dysfunction. Interleukin-34 (IL-34), known for its ro...

    Authors: Mehdi Karasu and Hasan Ata Bolayır
    Citation: BMC Cardiovascular Disorders 2024 24:2
  8. Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD).

    Authors: Nadia Bouzidi and Habib Gamra
    Citation: BMC Cardiovascular Disorders 2023 23:586
  9. Renal function decline is a frequently encountered complication in patients with chronic coronary syndrome. Aside from traditional cardiovascular risk factors, the inflammatory burden emerged as the novel phen...

    Authors: Ting-Wei Kao, Chin-Chou Huang, Hsin-Bang Leu, Wei-Hsian Yin, Wei-Kung Tseng, Yen-Wen Wu, Tsung-Hsien Lin, Hung-I Yeh, Kuan-Cheng Chang, Ji-Hung Wang, Chau-Chung Wu and Jaw-Wen Chen
    Citation: BMC Cardiovascular Disorders 2023 23:564
  10. Inflammation and immune cells are closely intertwined mechanisms that contribute to the progression of heart failure (HF). Nonetheless, there is a paucity of information regarding the distinct features of dysr...

    Authors: Shengnan Li, Tiantian Ge, Xuan Xu, Liang Xie, Sifan Song, Runqian Li, Hao Li and Jiayi Tong
    Citation: BMC Cardiovascular Disorders 2023 23:560
  11. Monocytes and dendritic cells (DC) are both key inflammatory cells, with recognized effects on cardiac repair. However, there are distinct subsets of monocytes with potential for beneficial or detrimental effe...

    Authors: Sílvia Martins, Natália António, Ricardo Rodrigues, Tiago Carvalheiro, Cândida Tomaz, Lino Gonçalves and Artur Paiva
    Citation: BMC Cardiovascular Disorders 2023 23:558
  12. The development of new-onset atrial fibrillation (NOAF) after acute myocardial infarction (AMI) is a clinical complication that requires a better understanding of the causative risk factors. This study aimed t...

    Authors: Qingyi Zeng, Wei Li, Zhenghua Luo, Haiyan Zhou, Zhonggang Duan and Xin Lin Xiong
    Citation: BMC Cardiovascular Disorders 2023 23:448
  13. Allicin is a bioactive compound with potent antioxidative activity and plays a protective effect in myocardial damage and fibrosis. The role and mechanism of Allicin in septic cardiomyopathy are unclear. In th...

    Authors: Fangyuan Sun, Kailiang Xu, Jiayi Zhou, Wei Zhang, Guihe Duan and Ming Lei
    Citation: BMC Cardiovascular Disorders 2023 23:410
  14. Cardiac remodeling and dysfunction can be caused by atrial fibrillation (AF). The aim of this research is to investigate the relationship between the systemic inflammatory response index (SIRI) and left ventri...

    Authors: Runze Chi, Xiaoli Shan, ChunPing Guan, Hao Yang, Xiangkun Wang, Bingong Li and Qing Zhang
    Citation: BMC Cardiovascular Disorders 2023 23:377
  15. Heart failure (HF) continues to be the major cause of hospitalizations. Despite numerous significant therapeutic progress, the mortality rate of HF is still high. This longitudianl cohort study aimed to invest...

    Authors: Chia-Chen Wu, Chia-Hui Wu, Chien-Ho Lee and Cheng-I Cheng
    Citation: BMC Cardiovascular Disorders 2023 23:312
  16. Diabetes is a serious and quickly expanding global health problem. Cardiovascular disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM) patients. Coronary slow flow (CSF) is characterise...

    Authors: Moataz Ali Hasan Ali Elsanan, Islam Hussein Hassan Hussein Tahoon, Ghada Ibrahim Mohamed, Shimaa Gamal ZeinElabdeen and Islam Elsayed Shehata
    Citation: BMC Cardiovascular Disorders 2023 23:244
  17. Acute coronary syndrome(ACS) is the leading cause of mortality and disability worldwide. Immune response has been confirmed to play a vital role in the occurrence and development of ACS. The objective of this ...

    Authors: Muzhi Lin, Bing Wang, Bo Wei, Chao Li, Lin Tu, Xiaohan Zhu, Zheyi Wu, Guangwei Huang, Xiyang Lu, Guobao Xiong, Shanglin Lu, Xinglin Yang, Peng Li, Xingde Liu, Wei Li, Yuming Lu…
    Citation: BMC Cardiovascular Disorders 2023 23:220
  18. Recent studies have developed our understanding of the role of the immune system and inflammation in Cardiovascular Disease (CVD), opening new avenues for risk stratification and therapeutic intervention. Howe...

    Authors: Vennela Boyalla, Enrique Gallego-Colon and Michael Spartalis
    Citation: BMC Cardiovascular Disorders 2023 23:148
  19. Atherosclerosis (AS) is a chronic inflammatory disease, as a main cause leading to vascular diseases worldwide. Although increasing studies have focused on macrophages in AS, the exact relating mechanism is st...

    Authors: Juping Wang, Congna Zhao, Baonan Zhang and Xiaoyan Liu
    Citation: BMC Cardiovascular Disorders 2023 23:141

Submission Guidelines

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This Collection welcomes submission of Research Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Immunity and inflammation in Cardiovascular Disorders" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.