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Immunobiology of Human Space Exploration

Topical Collection for Immunity & Ageing: Immunobiology of Human Space Exploration, Guest Edited by Brian E. Crucian and Richard J. Simpson.

Space travel is associated with immune dysregulation that may increase clinical risk in future exploration crew. Prolonged orbital spaceflight missions have shown a number of immune and clinical changes that are akin to advanced human aging, including alterations to the peripheral T-cell and NK-cell compartments, impairments in humoral immunity, latent viral reactivation, and persistent hypersensitivity. We seek articles that are focused on immune dysregulation during spaceflight and spaceflight analog environments, particularly when immunological endpoints that overlap with human aging are considered. Articles focused on the effectiveness of countermeasures designed to mitigate the risk of immune dysregulation during space travel are particularly encouraged. Articles may be commentaries or original research.

This Collection welcomes submission of Research Articles, Data Notes, Case Reports, Study Protocols, and Database Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Immunobiology of Human Space Exploration" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.


  1. The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned long-duration missions, such as the deployment of the Lunar Gateway and pos...

    Authors: Coralie Fonte, Pauline Jacob, Anne Vanet, Stéphanie Ghislin and Jean-Pol Frippiat
    Citation: Immunity & Ageing 2023 20:64