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Elimination of neglected tropical diseases

Guest edited by Robert Bergquist, Adrian Hopkins and Xiao-Nong Zhou

An article collection published in Infectious Diseases of Poverty.

New Content ItemInspired by the 'roadmap' developed by the World Health Organization (WHO) in 2011 for the control, elimination and eradication of a group of infectious diseases named neglected tropical diseases (NTDs), senior government officials from endemic and donor countries, global health organizations, major pharmaceutical companies, Bill Gates of the Bill & Melinda Gates Foundation and WHO's then Director General Margaret Chan signed the London Declaration in January 2012, a commitment to control or eliminate 10 diseases by the end of this decade. This joint effort to do something about infections strongly associated with poverty in tropical and subtropical environments, was endorsed by all member states through the World Health Assembly (WHA) NTD resolution (1948-2013) in 2013 and has since become the largest public health initiatives in history. Eliminate NTDs is indeed one of indicators listed in the United Nation’s Sustainable Development Goal (2015-2030), which is linked with a crucial component of universal health coverage aiming to lift the burden of disease from populations in low-income and middle-income countries with limited access to health services and conceptualized as “leaving no one behind”.

Stakeholders have chartered a course toward health and sustainability among the world’s poorest communities offering them global eradication of dracunculiasis, blinding trachoma, leprosy, human African trypanosomiasis, lymphatic filariasis and elimination at the regional level of rabies, endemic treponematoses (endemic syphilis, pinta and yaws), Chagas disease, visceral leishmaniasis, onchocerciasis and schistosomiasis by 2020. However, the fourth progress report from Uniting to Combat Neglected Tropical Diseases issued in 2016 finds that many deadlines have been missed. Still there is hope that the above mentioned five NTDs could be eliminated or eradicated within the next few years with continued significant gains for the other NTDs. On the other hand, for roughly an equal number of diseases (trichuriasis, hookworm disease, food-borne trematodiases, cystic echinococcosis) progress has been minimal or stalled. In some cases, we are losing ground, especially for some of the vector-borne and zoonotic diseases, including dengue and other arbovirus infections, leishmaniasis, Chagas disease.

This intention of this issue is to show the progress and challenges in NTD elimination in different geographic settings around the world giving the current status and prospects for each disease. Particularly, some of successive stories will be published to share experiences with other counties or regions in order to promote the global elimination program on NTDs. 

  1. In certain settings, the prevalence and severity of schistosoma infection do not lessen despite repeated rounds of preventative chemotherapy; these areas are known as hotspots. This study aimed to investigate ...

    Authors: Ramy Mohamed Ghazy, Walid Ismail Ellakany, Mai M. Badr, Nehad E. M. Taktak, Heba Elhadad, Sarah M. Abdo, Ayat Hagag, Abdel Rahman Hussein and Mohamed Mostafa Tahoun
    Citation: Infectious Diseases of Poverty 2022 11:102
  2. In its new roadmap for neglected tropical diseases, the World Health Organization proposes three important strategic shifts: (i) Stronger accountability which shifting from process to impact indicators; (ii) I...

    Authors: Melissa Krizia Vieri, Makoy Yibi Logora, Kamran Rafiq and Robert Colebunders
    Citation: Infectious Diseases of Poverty 2021 10:70
  3. The Upper West region of Ghana is mostly made up of rural communities and is highly endemic for lymphatic filariasis (LF), with a significant burden of disability due to lymphedema and hydrocele. The aim of th...

    Authors: Solomon Abotiba Atinbire, Benjamin Marfo, Bright Alomatu, Collins Ahorlu, Paul Saunderson and Stefanie Weiland
    Citation: Infectious Diseases of Poverty 2021 10:64
  4. As a neglected cross-species parasitic disease transmitted between canines and livestock, echinococcosis remains a global public health concern with a heavy disease burden. In China, especially in the epidemic...

    Authors: Shi-Jie Yang, Ning Xiao, Jing-Zhong Li, Yu Feng, Jun-Ying Ma, Gong-Sang Quzhen, Qing Yu, Ting Zhang, Shi-Cheng Yi and Xiao-Nong Zhou
    Citation: Infectious Diseases of Poverty 2021 10:50
  5. Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination. The aim of this study is to investigate the...

    Authors: Fang Huang, Li Zhang, Jing-Bo Xue, Hong-Ning Zhou, Aung Thi, Jun Zhang, Shui-Sen Zhou, Zhi-Gui Xia and Xiao-Nong Zhou
    Citation: Infectious Diseases of Poverty 2020 9:158
  6. Oncomelania hupensis is the only intermediate host of Schistosoma japonicum and plays a decisive role in its transmission. The variation of water level greatly affects the reproduction and growth of snails. There...

    Authors: Fei Hu, Qi-Yue Li, Xiao-Feng Dai, Zhao-Jun Li, Shang-Biao Lv, Chun-Fang Lu, Yi-Feng Li, Min Yuan, Yue-Ming Liu, Ying Liu and Dan-Dan Lin
    Citation: Infectious Diseases of Poverty 2020 9:103
  7. Since the founding of the People’s Republic of China in 1949, considerable progress has been made in the control and elimination of the country’s initial set of 11 neglected tropical diseases. Indeed, eliminat...

    Authors: Men-Bao Qian, Jin Chen, Robert Bergquist, Zhong-Jie Li, Shi-Zhu Li, Ning Xiao, Jürg Utzinger and Xiao-Nong Zhou
    Citation: Infectious Diseases of Poverty 2019 8:86
  8. Before the founding of the People’s Republic of China 70 years ago, both extreme poverty and parasitic infections and other neglected tropical diseases were highly prevalent. Owing to social development, parti...

    Authors: Peter J. Hotez
    Citation: Infectious Diseases of Poverty 2019 8:85
  9. Lymphatic filariasis is endemic in nine of the eleven Member States of the World Health Organization South East Asia Region. This article describes the intensive interventions with the National Programme for E...

    Authors: Sunsanee Rojanapanus, Tanaporn Toothong, Patcharida Boondej, Suwich Thammapalo, Naraporn Khuanyoung, Weena Santabutr, Preecha Prempree, Deyer Gopinath and Kapa D. Ramaiah
    Citation: Infectious Diseases of Poverty 2019 8:38

    The Correction to this article has been published in Infectious Diseases of Poverty 2019 8:72

  10. Helminths are endemic in more than half of the world’s countries, raising serious public health concerns. Accurate diagnosis of helminth infection is crucial to control strategies. Traditional parasitological ...

    Authors: Miao-Han Deng, Lan-Yi Zhong, Okanurak Kamolnetr, Yanin Limpanont and Zhi-Yue Lv
    Citation: Infectious Diseases of Poverty 2019 8:20
  11. Snail control is an important component in the national schistosomiasis control programme in China, by application of chemical molluscicides, forestry projects, agriculture projects and water conservancy proje...

    Authors: Xiao Yang, Yi Zhang, Qi-Xiang Sun, Jin-Xing Zhou and Xiao-Nong Zhou
    Citation: Infectious Diseases of Poverty 2019 8:13
  12. The recent development of rapid diagnostic tests (RDTs) for human African trypanosomiasis (HAT) enables elimination programmes to decentralise serological screening services to frontline health facilities. How...

    Authors: Shona J. Lee and Jennifer J. Palmer
    Citation: Infectious Diseases of Poverty 2018 7:84
  13. Schistosomiasis and soil-transmitted helminthiasis (STH) are endemic diseases in Burundi. STH control is integrated into health facilities (HF) across the country, but schistosomiasis control is not. The prese...

    Authors: Paul Bizimana, Katja Polman, Jean-Pierre Van Geertruyden, Frédéric Nsabiyumva, Céline Ngenzebuhoro, Elvis Muhimpundu and Giuseppina Ortu
    Citation: Infectious Diseases of Poverty 2018 7:66
  14. The prevalence of schistosomiasis japonica has decreased significantly, and the responses changing from control to elimination in Jiangsu Province, P.R. China. How to estimate the change in prevalence of schis...

    Authors: Xin-Yao Wang, Jing Xu, Song Zhao, Wei Li, Jian-Feng Zhang, Jian He, Ashley M. Swing and Kun Yang
    Citation: Infectious Diseases of Poverty 2018 7:62
  15. Lymphatic filariasis (LF) is endemic in Myanmar and targeted for elimination. To highlight the National Programme to Eliminate Lymphatic Filariasis (NPELF) progress between 2000 and 2014, this paper describes ...

    Authors: Ni Ni Aye, Zaw Lin, Khin Nan Lon, Nay Yi Yi Linn, Thet Wai Nwe, Khin Mon Mon, Kapa Ramaiah, Hannah Betts and Louise A. Kelly-Hope
    Citation: Infectious Diseases of Poverty 2018 7:56
  16. Endemicity of lymphatic filariasis (LF) in Cambodia was proven in 1956 when microfilariae were detected in mosquitos in the Kratié province. In 2001, an extensive study confirmed the presence of both Brugia malay...

    Authors: Virak Khieu, Vandine Or, Chhakda Tep, Peter Odermatt, Reiko Tsuyuoka, Meng Chuor Char, Molly A. Brady, Joshua Sidwell, Aya Yajima, Rekol Huy, Kapa D. Ramaiah and Sinuon Muth
    Citation: Infectious Diseases of Poverty 2018 7:15
  17. Historically, the target in the schistosomiasis control has shifted from infection to morbidity, then back to infection, but now as a public health problem, before moving on to transmission control. Currently,...

    Authors: Robert Bergquist, Xiao-Nong Zhou, David Rollinson, Jutta Reinhard-Rupp and Katharina Klohe
    Citation: Infectious Diseases of Poverty 2017 6:158
  18. Neglected tropical diseases (NTDs) prevail in conditions of poverty and contribute to the maintenance of social inequality. Out of the NTDs prioritized by the Brazilian Ministry of Health, four parasitic infec...

    Authors: Eduardo Brandão, Sebastián Romero, Maria Almerice Lopes da Silva and Fred Luciano Neves Santos
    Citation: Infectious Diseases of Poverty 2017 6:154
  19. Remarkable progress has been made in the fight against neglected tropical diseases, but new challenges have emerged. Innovative diagnostics, better drugs and new insecticides are often identified as the priori...

    Authors: Giuseppina Ortu and Oliver Williams
    Citation: Infectious Diseases of Poverty 2017 6:147