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IDDRC special issue 2023

Series Editors: Hyejung Won, PhD, Jessica Girault, PhD & Olivia Veatch, PhD

Journal of Neurodevelopmental Disorders is pleased to present this sixth IDDRC special thematic series focused on Etiological heterogeneity, pleiotropy, and polygenicity in Intellectual and Developmental Disabilities (IDDs)

This collection of articles is sponsored by the Intellectual and Developmental Disabilities Research Centers (IDDRCs) and articles have undergone the journal’s standard peer-review process. The Series Editors declare no competing interests.

  1. Succinic semialdehyde dehydrogenase deficiency (SSADHD) represents a model neurometabolic disease at the fulcrum of translational research within the Boston Children’s Hospital Intellectual and Developmental D...

    Authors: Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin…
    Citation: Journal of Neurodevelopmental Disorders 2024 16:21
    Content type: Research Published on:

  2. Specifying early developmental differences among neurodevelopmental disorders with distinct etiologies is critical to improving early identification and tailored intervention during the first years of life. Re...

    Authors: Lindsay J. Mullin, Joshua Rutsohn, Julia L. Gross, Kelly E. Caravella, Rebecca L. Grzadzinski, Leigh Anne Weisenfeld, Lisa Flake, Kelly N. Botteron, Stephen R. Dager, Annette M. Estes, Juhi Pandey, Robert T. Schultz, Tanya St. John, Jason J. Wolff, Mark D. Shen, Joseph Piven…
    Citation: Journal of Neurodevelopmental Disorders 2024 16:12
    Content type: Research Published on:

  4. Autism spectrum disorder (ASD) is associated with a diverse range of etiological processes, including both genetic and non-genetic causes. For a plurality of individuals with ASD, it is likely that the primary...

    Authors: Matthew W. Mosconi, Cassandra J. Stevens, Kathryn E. Unruh, Robin Shafer and Jed T. Elison
    Citation: Journal of Neurodevelopmental Disorders 2023 15:41
    Content type: Review Published on:

    The Correction to this article has been published in Journal of Neurodevelopmental Disorders 2024 16:4

  5. ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More...

    Authors: Quanfa He, Taylor J. Keding, Qi Zhang, Jiacheng Miao, Justin D. Russell, Ryan J. Herringa, Qiongshi Lu, Brittany G. Travers and James J. Li
    Citation: Journal of Neurodevelopmental Disorders 2023 15:30
    Content type: Research Published on:

  7. Although polygenic scores (PGS) for autism have been related to various psychiatric and medical conditions, most studies to date have been conducted in research ascertained populations. We aimed to identify th...

    Authors: Maria Niarchou, Tyne Miller-Fleming, Beth A. Malow and Lea K. Davis
    Citation: Journal of Neurodevelopmental Disorders 2023 15:18
    Content type: Research Published on:

  8. Epigenetics, one mechanism by which gene expression can change without any changes to the DNA sequence, was described nearly a century ago. However, the importance of epigenetic processes to neurodevelopment a...

    Authors: Rowena Ng, Allison Kalinousky and Jacqueline Harris
    Citation: Journal of Neurodevelopmental Disorders 2023 15:16
    Content type: Review Published on:

  9. Neurodevelopmental disorders (NDDs), such as attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), are examples of complex and partially overlapping phenotypes that often lack def...

    Authors: Joseph T. Glessner, Munir E. Khan, Xiao Chang, Yichuan Liu, F. George Otieno, Maria Lemma, Isabella Slaby, Heather Hain, Frank Mentch, Jin Li, Charlly Kao, Patrick M. A. Sleiman, Michael E. March, John Connolly and Hakon Hakonarson
    Citation: Journal of Neurodevelopmental Disorders 2023 15:14
    Content type: Research Published on: