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Hydrocephalus: Promoting research for improved outcomes

This collection is a series of articles published in Fluids and Barriers of the CNS by members of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders. This series is headed by two commissioned task force reviews (Vinchon et al.; Malm et al.) reporting important research into hydrocephalus and aiming to stimulate future research, with the particular objective of improving the quality of life for patients.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

  1. Research

    MRI assessment of the effects of acetazolamide and external lumbar drainage in idiopathic Normal Pressure Hydrocephalus

    The objective was to identify changes in quantitative MRI measures in patients with idiopathic normal pressure hydrocephalus (iNPH) occurring in common after oral acetazolamide (ACZ) and external lumbar draina...

    Milos Ivkovic, Martin Reiss-Zimmermann, Heather Katzen, Matthias Preuss, Ilhami Kovanlikaya, Linda Heier, Noam Alperin, Karl T Hoffmann and Norman Relkin

    Fluids and Barriers of the CNS 2015 12:9

    Published on: 2 April 2015

  2. Research

    Kaolin-induced chronic hydrocephalus accelerates amyloid deposition and vascular disease in transgenic rats expressing high levels of human APP

    Normal pressure hydrocephalus (NPH) is most common in the elderly and has a high co-morbidity with Alzheimer’s disease (AD) and cerebrovascular disease (CVD). To understand the relationship between NPH, AD and...

    Gerald D Silverberg, Miles C Miller, Crissey L Pascale, Ilias N Caralopoulos, Yuksel Agca, Cansu Agca and Edward G Stopa

    Fluids and Barriers of the CNS 2015 12:2

    Published on: 24 January 2015

  3. Short paper

    Increased prevalence of cardiovascular disease in idiopathic normal pressure hydrocephalus patients compared to a population-based cohort from the HUNT3 survey

    Idiopathic normal pressure hydrocephalus (iNPH) is one of few types of dementia that can be treated with shunt surgery and cerebrospinal fluid (CSF) diversion. It is frequently present with cerebral vasculopat...

    Per Kristian Eide and Are Hugo Pripp

    Fluids and Barriers of the CNS 2014 11:19

    Published on: 19 August 2014

  4. Review

    A new look at cerebrospinal fluid circulation

    According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and the subarachnoid ...

    Thomas Brinker, Edward Stopa, John Morrison and Petra Klinge

    Fluids and Barriers of the CNS 2014 11:10

    Published on: 1 May 2014

  5. Research

    Association of lipocalin-type prostaglandin D synthase with disproportionately enlarged subarachnoid-space in idiopathic normal pressure hydrocephalus

    Idiopathic normal pressure hydrocephalus (iNPH) is a treatable cause of dementia, gait disturbance, and urinary incontinence in elderly patients with ventriculomegaly. Its unique morphological feature, called ...

    Namiko Nishida, Nanae Nagata, Hiroki Toda, Naoto Jingami, Kengo Uemura, Akihiko Ozaki, Mitsuhito Mase, Yoshihiro Urade, Sadayuki Matsumoto, Koichi Iwasaki and Masatsune Ishikawa

    Fluids and Barriers of the CNS 2014 11:9

    Published on: 15 April 2014

  6. Review

    Influence of comorbidities in idiopathic normal pressure hydrocephalus — research and clinical care. A report of the ISHCSF task force on comorbidities in INPH

    Idiopathic normal pressure hydrocephalus (INPH) is a syndrome of ventriculomegaly, gait impairment, cognitive decline and incontinence that occurs in an elderly population prone to many types of comorbidities....

    Jan Malm, Neill R Graff-Radford, Masatsune Ishikawa, Bo Kristensen, Ville Leinonen, Etsuro Mori, Brian K Owler, Mats Tullberg, Michael A Williams and Norman R Relkin

    Fluids and Barriers of the CNS 2013 10:22

    Published on: 10 June 2013

  7. Review

    Pediatric hydrocephalus outcomes: a review

    The outcome of pediatric hydrocephalus, including surgical complications, neurological sequelae and academic achievement, has been the matter of many studies. However, much uncertainty remains, regarding the v...

    Matthieu Vinchon, Harold Rekate and Abhaya V Kulkarni

    Fluids and Barriers of the CNS 2012 9:18

    Published on: 27 August 2012