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Hyphenated mass spectrometry strategies as tools for unveiling peptide toxins with potential therapeutic application

Call for papers

© Daniel PimentaJournal of Venomous Animals and Toxins including Tropical Diseases is now accepting submissions to be considered for publication in a thematic series on hyphenated mass spectrometry strategies as tools for unveiling peptide toxins with potential therapeutic application.

Edited by Daniel Pimenta (Butantan Institute, Brazil) and Philippe Bulet (University Grenoble Alpes, France) as guest editors, the collection will accept research and review manuscript submissions and will also include commissioned topical reviews, written by leaders in the field.

Hyphenated mass spectrometry (MS) strategies have been successfully employed as tools for unveiling peptide toxins and other bioactive peptides, such as proteins from venoms and secretions. The association of genome mining, complementary “omics” and/or bar-coding of complex matrices with structural characterization by MS and pharmacological studies on the structure-activity relationship of such novel molecules provides armamentarium for new therapeutics targets and candidates.

Under this broad thematic umbrella, the series will cover research topics on peptides with functional properties such as antimicrobial, toxic, lytic, vasoactive, anti-proliferative, antiviral, anti-tumoral, immunomodulators and enzyme inhibitors.

The deadline for submissions is May 10th 2017.

Manuscripts should be formatted according to our submission guidelines and submitted via the online submission system. In the submission system please make sure the correct collection title is chosen from the additional information tab. Please also indicate clearly in the covering letter that the manuscript is to be considered for the Hyphenated Mass Spectrometry Strategies as Tools for Unveiling Peptide Toxins with Potential Therapeutic Application series.

If you would like to enquiry about the suitability of a manuscript for consideration, please email a pre-submission enquiry to editorial@jvat.org.br.

See other article collections published in the journal.

Visit the journal homepage.


  1. Content type: Research

    Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin....

    Authors: Laudicéia Alves de Oliveira, Rui Seabra Ferreira Jr, Benedito Barraviera, Francilene Capel Tavares de Carvalho, Luciana Curtolo de Barros, Lucilene Delazari dos Santos and Daniel Carvalho Pimenta

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:46

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  2. Content type: Review

    The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoform...

    Authors: Rafael D. Melani, Fabio C. S. Nogueira and Gilberto B. Domont

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:44

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  3. Content type: Research

    Sea urchins are animals commonly found on the Brazilian shoreline, being Echinometra lucunter the most abundant species. Accidents caused by E. lucunter have been reported as one of the most frequent in Brazil, a...

    Authors: Juliana Mozer Sciani, Bianca Zychar, Luis Roberto Gonçalves, Renata Giorgi, Thiago Nogueira and Daniel Carvalho Pimenta

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:43

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  4. Content type: Research

    Among the hymenopteran insect venoms, those from social wasps and bees – such as honeybee, hornets and paper wasps – have been well documented. Their venoms are composed of a number of peptides and proteins an...

    Authors: Kohei Kazuma, Kenji Ando, Ken-ichi Nihei, Xiaoyu Wang, Marisa Rangel, Marcia Regina Franzolin, Kanami Mori-Yasumoto, Setsuko Sekita, Makoto Kadowaki, Motoyoshi Satake and Katsuhiro Konno

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:40

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  5. Content type: Research

    Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (B...

    Authors: Tamara M. Fucase, Juliana M. Sciani, Ingrid Cavalcante, Vincent L. Viala, Bruno B. Chagas, Daniel C. Pimenta and Patrick J. Spencer

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:33

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  6. Content type: Research

    Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern am...

    Authors: Tatiana Rodrigues Alexandre, Marta Lopes Lima, Mariana Kolos Galuppo, Juliana Tonini Mesquita, Matilia Ana do Nascimento, Augusto Leonardo dos Santos, Patricia Sartorelli, Daniel Carvalho Pimenta and Andre Gustavo Tempone

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:30

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  7. Content type: Research

    Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfull...

    Authors: Hiroko Kawakami, Shin G. Goto, Kazuya Murata, Hideaki Matsuda, Yasushi Shigeri, Tomohiro Imura, Hidetoshi Inagaki and Tetsuro Shinada

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:29

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  8. Content type: Review

    In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level...

    Authors: Juan J. Calvete, Daniel Petras, Francisco Calderón-Celis, Bruno Lomonte, Jorge Ruiz Encinar and Alfredo Sanz-Medel

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:27

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  9. Content type: Review

    This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achie...

    Authors: Bruno Lomonte and Juan J. Calvete

    Citation: Journal of Venomous Animals and Toxins including Tropical Diseases 2017 23:26

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