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Measuring HIV-1 persistence in vivo

New Content ItemEdited by Ben Berkhout and Alexander Pasternak
Retrovirology

Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. HIV-1 forms a reservoir that persists despite prolonged therapy and is considered the main barrier to an HIV cure. Being able to accurately measure HIV persistence in ART-treated individuals is necessary for monitoring the response to ART, as well as the effectiveness of curative interventions aimed at HIV remission. This thematic series in Retrovirology contains a collection of review articles that describe traditional and novel methods of quantitation of HIV persistence in vivo.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer review process. The Editors declare no competing interests.

View all collections published in Retrovirology

  1. Content type: Review

    The development of increasingly safe and effective antiretroviral treatments for human immunodeficiency virus (HIV) over the past several decades has led to vastly improved patient survival when treatment is a...

    Authors: Claire Deleage, Chi N. Chan, Kathleen Busman-Sahay and Jacob D. Estes

    Citation: Retrovirology 2018 15:4

    Published on:

  2. Content type: Review

    A robust measure of the size of the latent HIV reservoir is essential to quantifying the effect of interventions designed to deplete the pool of reactivatable, replication competent proviruses. In addition to ...

    Authors: Nicholas J. Norton, Axel Fun, Mikaila Bandara, Mark R. Wills, Hoi Ping Mok and Andrew M. L. Lever

    Citation: Retrovirology 2017 14:58

    Published on:

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