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HIV vaccine development in Canada

New Content ItemEdited by Eric Arts and Yong Gao

On December 14th and 15th 2016, in Ottawa, Ontario, the Canadian HIV Vaccine Initiative (CHVI) Research and Development Alliance Coordinating Office (ACO) hosted Canadian researchers to discuss past successes and current priorities related to advancing HIV vaccine research in Canada.  About 30 Canadian scientists involved in vaccine research were joined by scientific representatives from the International and European AIDS vaccine initiatives (IAVI and EAVI2020, respectively), by keynote speakers Dr. William Schief from the Scripps Research Institute and Dr. Robin Shattock from Imperial College London, and by representatives from Canadian Federal government funding agencies, including the Public Health Agency of Canada (PHAC), Ministry of Health, and the Canadian Institutes of Health Research (CIHR).

The meeting featured a number of sessions highlighting the HIV vaccine research projects, both large and small, that have been funded by the CHVI over last 10 years. Our Canadian scientists are also internationally renowned researchers working in the area of HIV vaccine research with world leading strengths. Discussions amongst our research colleagues and invited guests, Drs. Schief and Shattock, identified a clear need for increased solidarity within the HIV vaccine research community, for enhanced partnerships with larger global vaccine consortia (e.g. IAVI and EAVI2020), and the need to highlight the incredible contributions by Canadian scientist to area of vaccine development. In relation to the latter, AIDS Research and Therapy has commissioned a special issue devoted to HIV vaccine-related research and entertained submission by Canadian researchers. This issue is not intended to highlight Canadian-centric research in this area but instead to showcase how Canadian scientist contribute to the overall goal of developing an effective HIV vaccine. The authors in this issue provide outstanding and clear opinions/reviews on key topics related to understanding the underlying factors for vaccine design, vaccine delivery strategies, adjuvants, and other prevention measures, as well as therapeutic vaccines.

This collection of articles has been partially sponsored. All articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

View all collections in AIDS Research and Therapy.

  1. Review

    Unlocking HIV-1 Env: implications for antibody attack

    Collective evidence supporting a role of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) in controlling HIV-1 transmission and disease progression emerged in the last few years. Non-neutralizing antibodie...

    Jonathan Richard, Shilei Ding and Andrés Finzi

    AIDS Research and Therapy 2017 14:42

    Published on: 12 September 2017

  2. Review

    Natural killer (NK) cell receptor-HLA ligand genotype combinations associated with protection from HIV infection: investigation of how protective genotypes influence anti HIV NK cell functions

    The anti-HIV activity of natural killer (NK) cells could be induced fast enough to potentially prevent the establishment of HIV infection. Epidemiological studies identified two genotypes encoding NK receptors...

    Nicole F. Bernard

    AIDS Research and Therapy 2017 14:38

    Published on: 12 September 2017

  3. Review

    Development of targeted adjuvants for HIV-1 vaccines

    Finding new adjuvants is an integrated component of the efforts in developing an effective HIV-1 vaccine. Compared with traditional adjuvants, a modern adjuvant in the context of HIV-1 prevention would elicit ...

    Jun Liu and Mario Ostrowski

    AIDS Research and Therapy 2017 14:43

    Published on: 12 September 2017

  4. Review

    Eradication of HIV-1 latent reservoirs through therapeutic vaccination

    Despite the significant success of combination anti-retroviral therapy to reduce HIV viremia and save lives, HIV-1 infection remains a lifelong infection that must be appropriately managed. Advances in the und...

    Joshua Pankrac, Katja Klein and Jamie F. S. Mann

    AIDS Research and Therapy 2017 14:45

    Published on: 12 September 2017

  5. Review

    A novel HIV vaccine targeting the protease cleavage sites

    HIV preferentially infects activated CD4+ T cells and mutates rapidly. The classical vaccine approach aimed to generate broad immune responses to full HIV proteins largely failed to address the potential adver...

    Hongzhao Li, Robert W. Omange, Francis A. Plummer and Ma Luo

    AIDS Research and Therapy 2017 14:51

    Published on: 12 September 2017

  6. Review

    Development of an HIV vaccine using a vesicular stomatitis virus vector expressing designer HIV-1 envelope glycoproteins to enhance humoral responses

    Vesicular stomatitis virus (VSV), like many other Rhabdoviruses, have become the focus of intense research over the past couple of decades based on their suitability as vaccine vectors, transient gene delivery...

    Trina Racine, Gary P. Kobinger and Eric J. Arts

    AIDS Research and Therapy 2017 14:55

    Published on: 12 September 2017