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HIV Intervention Using Mouse Models for Viruses

Thematic Series

Edited by 
J Victor Garcia-Martinez, University of North Carolina, Chapel Hill, USA
Angela Wahl, University of North Carolina, Chapel Hill, USA

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This series, published in Retrovirology, presents a collection of articles describing the state of the art in small animal models for HIV research. 

It is intended to highlight the progress made and how these models have been utilized to address issues of fundamental importance in HIV research. In addition, it aims to shed light on what limitation of the current models should be considered in planning future experiments that use these systems, and what might be expected from the next generation of precision small animal models for HIV research.

View all collections in Retrovirology.

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  1. The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an established model of HIV infection, but defects in immune t...

    Authors: Alex J. Holloway, Tais B. Saito, Kubra F. Naqvi, Matthew B. Huante, Xiuzhen Fan, Joshua G. Lisinicchia, Benjamin B. Gelman, Janice J. Endsley and Mark A. Endsley
    Citation: Retrovirology 2024 21:8
  2. Humanized mice have become an important workhorse model for HIV research. Advances that enabled development of a human immune system in immune deficient mouse strains have aided new basic research in HIV patho...

    Authors: Janice J. Endsley, Matthew B. Huante, Kubra F. Naqvi, Benjamin B. Gelman and Mark A. Endsley
    Citation: Retrovirology 2021 18:14
  3. Humanized mice model human disease and as such are used commonly for research studies of infectious, degenerative and cancer disorders. Recent models also reflect hematopoiesis, natural immunity, neurobiology,...

    Authors: Prasanta K. Dash, Santhi Gorantla, Larisa Poluektova, Mahmudul Hasan, Emiko Waight, Chen Zhang, Milica Markovic, Benson Edagwa, Jatin Machhi, Katherine E. Olson, Xinglong Wang, R. Lee Mosley, Bhavesh Kevadiya and Howard E. Gendelman
    Citation: Retrovirology 2021 18:13
  4. The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and ...

    Authors: Yash Agarwal, Cole Beatty, Shivkumar Biradar, Isabella Castronova, Sara Ho, Kevin Melody and Moses Turkle Bility
    Citation: Retrovirology 2020 17:8