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Herpesviridae

Herpes viruses are major causes of morbidity and mortality worldwide, responsible for a broad range of diseases in humans and animals. Their large genomes, unique ability to form latent infections and aetiological role in several human cancers make them one of the most studied families of viruses.

This collection brings together articles from Virology Journal and Herpesviridae that explore our understanding of herpes viruses and provide an invaluable resource for the field.

  1. Content type: Research

    Many viral genes affect cytokine function within infected hosts, with interleukin 10 (IL-10) as a commonly targeted mediator. Epstein-Barr virus (EBV) encodes an IL-10 homologue (vIL-10) expressed during produ...

    Authors: Gary J Lindquester, Kimberly A Greer, James P Stewart and Jeffery T Sample

    Citation: Herpesviridae 2014 5:1

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  2. Content type: Short report

    Herpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in end...

    Authors: Marianna Politou, Dimitrios Koutras, Georgios Kaparos, Serena Valsami, Theodoros Pittaras, Emmanouil Logothetis, George Panayiotakopoulos and Evangelia Kouskouni

    Citation: Virology Journal 2014 11:153

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  3. Content type: Research

    Oral mucosa is frequently exposed to Herpes simplex virus type 1 (HSV-1) infection and irradiation due to dental radiography. During radiotherapy for oral cancer, the surrounding clinically normal tissues are ...

    Authors: Aaro Turunen, Veijo Hukkanen, Michaela Nygårdas, Jarmo Kulmala and Stina Syrjänen

    Citation: Virology Journal 2014 11:125

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  4. Content type: Research

    Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin’s Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-L...

    Authors: Charlotte Sueur, Julien Lupo, Philippe Mas, Patrice Morand and Véronique Boyer

    Citation: Virology Journal 2014 11:94

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  5. Content type: Review

    Since the type of herpes simplex virus (HSV) infection affects prognosis and subsequent counseling, type-specific testing to distinguish HSV-1 from HSV-2 is always recommended. Although PCR has been the diagno...

    Authors: Jérôme LeGoff, Hélène Péré and Laurent Bélec

    Citation: Virology Journal 2014 11:83

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    The Erratum to this article has been published in Virology Journal 2015 12:167

  6. Content type: Methodology

    Murine cytomegalovirus (MCMV) is increasingly used as an infectious model to investigate host-pathogen interactions in mice. Detailed methods have been published for using primary murine embryonic fibroblasts ...

    Authors: Katherine A Zurbach, Toktam Moghbeli and Christopher M Snyder

    Citation: Virology Journal 2014 11:71

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  7. Content type: Research

    Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and ...

    Authors: Samantha L Semenkow, Nicole M Johnson, David J Maggs and Barry J Margulies

    Citation: Virology Journal 2014 11:34

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  8. Content type: Research

    Epstein-Barr Virus (EBV) latently infects ~10% of gastric carcinomas (GC). Epstein-Barr Nuclear Antigen 1 (EBNA1) is expressed in EBV-associated GC, and can bind host DNA, where it may impact cellular gene reg...

    Authors: Fang Lu, Italo Tempera, Hyunna T Lee, Karen DeWispelaere and Paul M Lieberman

    Citation: Virology Journal 2014 11:12

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  9. Content type: Research

    Human cytomegalovirus (HCMV) infection is associated with cardiovascular disease (CVD) but the role of this virus in CVD progression remains unclear. We aimed to examine the HCMV serostatus in Russian patients...

    Authors: Koon-Chu Yaiw, Olga Ovchinnikova, Chato Taher, Abdul-Aleem Mohammad, Belghis Davoudi, Eugene Shlyakhto, Oxana Rotar, Alexandra Konradi, Vanessa Wilhelmi, Afsar Rahbar, Lynn Butler, Alice Assinger and Cecilia Söderberg-Nauclér

    Citation: Herpesviridae 2013 4:3

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  10. Content type: Research

    Congenital human cytomegalovirus (HCMV) infection, a leading cause of birth defects, is most often manifested as neurological disorders. The pathogenesis of HCMV-induced neurological disorders is, however, lar...

    Authors: Hiroyuki Nakamura, Huanan Liao, Kahori Minami, Masashi Toyoda, Hidenori Akutsu, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Akihiro Umezawa, Ken-Ichi Imadome, Naoki Inoue and Shigeyoshi Fujiwara

    Citation: Herpesviridae 2013 4:2

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  11. Content type: Research

    Recently we identified a relationship between human cytomegalovirus (hCMV) and human salivary gland (SG) mucoepidermoid carcinoma (MEC) in over 90% of cases; tumorigenesis in these cases uniformly correlated w...

    Authors: Michael Melnick, Parish P Sedghizadeh, Krysta A Deluca and Tina Jaskoll

    Citation: Herpesviridae 2013 4:1

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  12. Content type: Research

    Innate recognition is essential in the antiviral response against infection by herpes simplex virus (HSV). Chemokines are important for control of HSV via recruitment of natural killer cells, T lymphocytes, an...

    Authors: Stine Søby, Rune R Laursen, Lars Østergaard and Jesper Melchjorsen

    Citation: Herpesviridae 2012 3:6

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  13. Content type: Research

    Glioblastoma multiforme (GBM) represent the most aggressive brain tumor with a median overall survival of about 12-15 months. Over 90% of GBM tumors have recently been shown to be infected with human cytomegal...

    Authors: Afsar Rahbar, Giuseppe Stragliotto, Abiel Orrego, Inti Peredo, Chato Taher, Jan Willems and Cecilia Söderberg-Naucler

    Citation: Herpesviridae 2012 3:3

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  14. Content type: Research

    Diagnosis of cytomegalovirus (CMV) infection is challenging because of the high rate of asymptomatic infection and the low specificity of associated symptoms and signs. As a result, laboratory testing is an es...

    Authors: Tricia A Bal, Glenn Armstrong and Xiang Y Han

    Citation: Herpesviridae 2012 3:2

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  15. Content type: Research

    X-linked lymphoproliferative syndrome (XLP) is a rare inherited immunodeficiency by an extreme vulnerability to Epstein-Barr virus (EBV) infection, frequently resulting in hemophagocytic lymphohistiocytosis (H...

    Authors: Xi Yang, Taizo Wada, Ken-Ichi Imadome, Naonori Nishida, Takeo Mukai, Mitsuhiro Fujiwara, Haruka Kawashima, Fumiyo Kato, Shigeyoshi Fujiwara, Akihiro Yachie, Xiaodong Zhao, Toshio Miyawaki and Hirokazu Kanegane

    Citation: Herpesviridae 2012 3:1

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  16. Content type: Research

    Murine cytomegalovirus (MCMV) is closely related to human cytomegalovirus (HCMV) which is responsible for a variety of diseases, including retinitis, in immunocompromised individuals. Small inhibitory RNA mole...

    Authors: Brendan Marshall, Ming Zhang and Sally S Atherton

    Citation: Herpesviridae 2011 2:9

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  17. Content type: Research

    The presence of human cytomegalovirus (HCMV) in male genital tract suggests its vertical transmission with spermatozoa and the development of a potentially dangerous fetal infection. The objective of the prese...

    Authors: Victor A Naumenko, Yurii A Tyulenev, Sergei A Yakovenko, Lubov' F Kurilo, Ludmila V Shileyko, Aleksander S Segal, Larisa E Zavalishina, Regina R Klimova, Anton S Tsibizov, Sergei V Alkhovskii and Alla A Kushch

    Citation: Herpesviridae 2011 2:7

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  18. Content type: Research

    Therapeutic vaccines can be designed to enhance existing T cell memory populations for increased protection against re-infection. In the case of herpes simplex virus type 1, recurrent disease results from reac...

    Authors: Susanne Himmelein, Anthony J St Leger, Jared E Knickelbein, Alexander Rowe, Michael L Freeman and Robert L Hendricks

    Citation: Herpesviridae 2011 2:5

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  19. Content type: Research

    Epstein Barr virus (EBV) is a lymphotrophic γ-herpesvirus that infects more than 90% of the adult human population. It transforms B cells in vitro and is associated with lymphomas in vivo. In most EBV carriers...

    Authors: Ming L Tsang and Christian Münz

    Citation: Herpesviridae 2011 2:4

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  20. Content type: Review

    Epstein-Barr Virus (EBV) belongs to the gammaherpesvirus family, members of which are oncogenic. Compared with other closely related herpesviruses, EBV has developed much more elaborate and sophisticated strat...

    Authors: Shunbin Ning

    Citation: Herpesviridae 2011 2:1

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  21. Content type: Review

    Autophagy delivers cytoplasmic constituents for lysosomal degradation, and thereby facilitates pathogen degradation and pathogen fragment loading onto MHC molecules for antigen presentation to T cells. Herpesv...

    Authors: Graham S Taylor, Josef Mautner and Christian Münz

    Citation: Herpesviridae 2011 2:2

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  22. Content type: Research

    Human cytomegalovirus (HCMV) establishes a persistent life-long infection, and can cause severe pathology in the fetus and the immunocompromised host[1]. Breast milk is the primary route of transmission in humans...

    Authors: Lualhati E Harkins, Lisa A Matlaf, Liliana Soroceanu, Katrin Klemm, William J Britt, Wenquan Wang, Kirby I Bland and Charles S Cobbs

    Citation: Herpesviridae 2010 1:8

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  23. Content type: Research

    Cytomegalovirus (CMV) infection has been associated with accelerated transplant vasculopathy. In this study, we assessed the effects of acute rat CMV (RCMV) infection on vessel remodeling in transplant vasculo...

    Authors: Monika K Grudzinska, Krzysztof Bojakowski, Joanna Soin, Frank Stassen, Cecilia Söderberg-Nauclér and Piotr Religa

    Citation: Herpesviridae 2010 1:7

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  24. Content type: Review

    Genetic mutant organisms pervade all areas of Biology. Early on, herpesviruses (HV) were found to be amenable to genetic analysis using homologous recombination techniques in eukaryotic cells. More recently, H...

    Authors: Regina Feederle, Emmalene J Bartlett and Henri-Jacques Delecluse

    Citation: Herpesviridae 2010 1:6

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  25. Content type: Research

    Human Cytomegalovirus (HCMV) has been implicated in the acceleration of vascular disease and chronic allograft rejection. Recently, the virus has been associated with glioblastoma and other tumors. We have pre...

    Authors: Jennifer Vomaske, Susan Varnum, Ryan Melnychuk, Patricia Smith, Ljiljana Pasa-Tolic, Janani I Shutthanandan and Daniel N Streblow

    Citation: Herpesviridae 2010 1:2

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  26. Content type: Research

    Herpesviruses are a major health concern for numerous organisms, including humans, causing both acute and chronic infections recurrent over an individual's lifespan. Marek's disease virus (MDV) is a highly con...

    Authors: Charmaine M Robinson, Henry D Hunt, Hans H Cheng and Mary E Delany

    Citation: Herpesviridae 2010 1:5

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  27. Content type: Short Report

    In Cuba, previous reports have shown an increase of epidemic KS, reaching a total of 120 cases by the end of 2007, despite the use of HAART. To evaluate and compare the role of human herpes virus 8 (HHV-8) vir...

    Authors: Vivian Kourí, Pedro A Martínez, Orestes Blanco, Virginia Capó, María E Rodríguez, María del C Dovigny, Lidia Cardellá, Angela Gala, Narciso A Jiménez, Consuelo Correa, Yoan Alemán, Lissette Pérez, Alina Álvarez and Ulrich Hengge

    Citation: Herpesviridae 2010 1:3

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