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Herpes viruses are major causes of morbidity and mortality worldwide, responsible for a broad range of diseases in humans and animals. Their large genomes, unique ability to form latent infections and aetiological role in several human cancers make them one of the most studied families of viruses.

This collection brings together articles from Virology Journal and Herpesviridae that explore our understanding of herpes viruses and provide an invaluable resource for the field.

  1. Research

    Epstein-Barr virus IL-10 gene expression by a recombinant murine gammaherpesvirus in vivoenhances acute pathogenicity but does not affect latency or reactivation

    Many viral genes affect cytokine function within infected hosts, with interleukin 10 (IL-10) as a commonly targeted mediator. Epstein-Barr virus (EBV) encodes an IL-10 homologue (vIL-10) expressed during produ...

    Gary J Lindquester, Kimberly A Greer, James P Stewart and Jeffery T Sample

    Herpesviridae 2014 5:1

    Published on: 24 September 2014

  2. Short report

    Seroprevalence of HHV-6 and HHV-8 among blood donors in Greece

    Herpes viruses infection transmitted through healthy but infected blood donors pose a danger to herpes-naive immunocompromised recipients. The risk of transfusion-related HHV-8 transmission is different in end...

    Marianna Politou, Dimitrios Koutras, Georgios Kaparos, Serena Valsami, Theodoros Pittaras, Emmanouil Logothetis, George Panayiotakopoulos and Evangelia Kouskouni

    Virology Journal 2014 11:153

    Published on: 27 August 2014

  3. Research

    Difference in cytokine production and cell cycle progression induced by Epstein-Barr virus Lmp1 deletion variants in Kmh2, a Hodgkin lymphoma cell line

    Epstein-Barr virus (EBV) is associated with 20-40% of Hodgkin’s Lymphoma (HL) cases. EBV-encoded latent membrane protein 1 (LMP1) is a well-known oncogenic protein and two C-terminal deletion variants, del30-L...

    Charlotte Sueur, Julien Lupo, Philippe Mas, Patrice Morand and Véronique Boyer

    Virology Journal 2014 11:94

    Published on: 19 May 2014

  4. Research

    Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture

    Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and ...

    Samantha L Semenkow, Nicole M Johnson, David J Maggs and Barry J Margulies

    Virology Journal 2014 11:34

    Published on: 22 February 2014

  5. Research

    High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy

    Human cytomegalovirus (HCMV) infection is associated with cardiovascular disease (CVD) but the role of this virus in CVD progression remains unclear. We aimed to examine the HCMV serostatus in Russian patients...

    Koon-Chu Yaiw, Olga Ovchinnikova, Chato Taher, Abdul-Aleem Mohammad, Belghis Davoudi, Eugene Shlyakhto, Oxana Rotar, Alexandra Konradi, Vanessa Wilhelmi, Afsar Rahbar, Lynn Butler, Alice Assinger and Cecilia Söderberg-Nauclér

    Herpesviridae 2013 4:3

    Published on: 14 November 2013

  6. Research

    Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress

    Congenital human cytomegalovirus (HCMV) infection, a leading cause of birth defects, is most often manifested as neurological disorders. The pathogenesis of HCMV-induced neurological disorders is, however, lar...

    Hiroyuki Nakamura, Huanan Liao, Kahori Minami, Masashi Toyoda, Hidenori Akutsu, Yoshitaka Miyagawa, Hajime Okita, Nobutaka Kiyokawa, Akihiro Umezawa, Ken-Ichi Imadome, Naoki Inoue and Shigeyoshi Fujiwara

    Herpesviridae 2013 4:2

    Published on: 21 October 2013

  7. Research

    Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin

    Recently we identified a relationship between human cytomegalovirus (hCMV) and human salivary gland (SG) mucoepidermoid carcinoma (MEC) in over 90% of cases; tumorigenesis in these cases uniformly correlated w...

    Michael Melnick, Parish P Sedghizadeh, Krysta A Deluca and Tina Jaskoll

    Herpesviridae 2013 4:1

    Published on: 23 January 2013

  8. Research

    Low levels of Human Cytomegalovirus Infection in Glioblastoma multiforme associates with patient survival; -a case-control study

    Glioblastoma multiforme (GBM) represent the most aggressive brain tumor with a median overall survival of about 12-15 months. Over 90% of GBM tumors have recently been shown to be infected with human cytomegal...

    Afsar Rahbar, Giuseppe Stragliotto, Abiel Orrego, Inti Peredo, Chato Taher, Jan Willems and Cecilia Söderberg-Naucler

    Herpesviridae 2012 3:3

    Published on: 16 March 2012

  9. Research

    Evaluation of the IMMULITE®2000 CMV IgM assay

    Diagnosis of cytomegalovirus (CMV) infection is challenging because of the high rate of asymptomatic infection and the low specificity of associated symptoms and signs. As a result, laboratory testing is an es...

    Tricia A Bal, Glenn Armstrong and Xiang Y Han

    Herpesviridae 2012 3:2

    Published on: 29 February 2012

  10. Research

    Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 2

    X-linked lymphoproliferative syndrome (XLP) is a rare inherited immunodeficiency by an extreme vulnerability to Epstein-Barr virus (EBV) infection, frequently resulting in hemophagocytic lymphohistiocytosis (H...

    Xi Yang, Taizo Wada, Ken-Ichi Imadome, Naonori Nishida, Takeo Mukai, Mitsuhiro Fujiwara, Haruka Kawashima, Fumiyo Kato, Shigeyoshi Fujiwara, Akihiro Yachie, Xiaodong Zhao, Toshio Miyawaki and Hirokazu Kanegane

    Herpesviridae 2012 3:1

    Published on: 10 February 2012

  11. Research

    Detection of human cytomegalovirus in motile spermatozoa and spermatogenic cells in testis organotypic culture

    The presence of human cytomegalovirus (HCMV) in male genital tract suggests its vertical transmission with spermatozoa and the development of a potentially dangerous fetal infection. The objective of the prese...

    Victor A Naumenko, Yurii A Tyulenev, Sergei A Yakovenko, Lubov' F Kurilo, Ludmila V Shileyko, Aleksander S Segal, Larisa E Zavalishina, Regina R Klimova, Anton S Tsibizov, Sergei V Alkhovskii and Alla A Kushch

    Herpesviridae 2011 2:7

    Published on: 28 June 2011

  12. Research

    Circulating herpes simplex type 1 (HSV-1)-specific CD8+T cells do not access HSV-1 latently infected trigeminal ganglia

    Therapeutic vaccines can be designed to enhance existing T cell memory populations for increased protection against re-infection. In the case of herpes simplex virus type 1, recurrent disease results from reac...

    Susanne Himmelein, Anthony J St Leger, Jared E Knickelbein, Alexander Rowe, Michael L Freeman and Robert L Hendricks

    Herpesviridae 2011 2:5

    Published on: 15 March 2011

  13. Review

    Innate immune modulation in EBV infection

    Epstein-Barr Virus (EBV) belongs to the gammaherpesvirus family, members of which are oncogenic. Compared with other closely related herpesviruses, EBV has developed much more elaborate and sophisticated strat...

    Shunbin Ning

    Herpesviridae 2011 2:1

    Published on: 5 January 2011

  14. Review

    Autophagy in herpesvirus immune control and immune escape

    Autophagy delivers cytoplasmic constituents for lysosomal degradation, and thereby facilitates pathogen degradation and pathogen fragment loading onto MHC molecules for antigen presentation to T cells. Herpesv...

    Graham S Taylor, Josef Mautner and Christian Münz

    Herpesviridae 2011 2:2

    Published on: 5 January 2011

  15. Research

    Detection of human cytomegalovirus in normal and neoplastic breast epithelium

    Human cytomegalovirus (HCMV) establishes a persistent life-long infection, and can cause severe pathology in the fetus and the immunocompromised host[1]. Breast milk is the primary route of transmission in humans...

    Lualhati E Harkins, Lisa A Matlaf, Liliana Soroceanu, Katrin Klemm, William J Britt, Wenquan Wang, Kirby I Bland and Charles S Cobbs

    Herpesviridae 2010 1:8

    Published on: 23 December 2010

  16. Research

    RCMV increases intimal hyperplasia by inducing inflammation, MCP-1 expression and recruitment of adventitial cells to intima

    Cytomegalovirus (CMV) infection has been associated with accelerated transplant vasculopathy. In this study, we assessed the effects of acute rat CMV (RCMV) infection on vessel remodeling in transplant vasculo...

    Monika K Grudzinska, Krzysztof Bojakowski, Joanna Soin, Frank Stassen, Cecilia Söderberg-Nauclér and Piotr Religa

    Herpesviridae 2010 1:7

    Published on: 23 December 2010

  17. Review

    Epstein-Barr virus genetics: talking about the BAC generation

    Genetic mutant organisms pervade all areas of Biology. Early on, herpesviruses (HV) were found to be amenable to genetic analysis using homologous recombination techniques in eukaryotic cells. More recently, H...

    Regina Feederle, Emmalene J Bartlett and Henri-Jacques Delecluse

    Herpesviridae 2010 1:6

    Published on: 7 December 2010

  18. Research

    HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase

    Human Cytomegalovirus (HCMV) has been implicated in the acceleration of vascular disease and chronic allograft rejection. Recently, the virus has been associated with glioblastoma and other tumors. We have pre...

    Jennifer Vomaske, Susan Varnum, Ryan Melnychuk, Patricia Smith, Ljiljana Pasa-Tolic, Janani I Shutthanandan and Daniel N Streblow

    Herpesviridae 2010 1:2

    Published on: 7 December 2010

  19. Short Report

    Simultaneous quantification of human herpesvirus 8 DNA by real time PCR in different tissues of HIV infected cuban patients with Kaposi's sarcoma

    In Cuba, previous reports have shown an increase of epidemic KS, reaching a total of 120 cases by the end of 2007, despite the use of HAART. To evaluate and compare the role of human herpes virus 8 (HHV-8) vir...

    Vivian Kourí, Pedro A Martínez, Orestes Blanco, Virginia Capó, María E Rodríguez, María del C Dovigny, Lidia Cardellá, Angela Gala, Narciso A Jiménez, Consuelo Correa, Yoan Alemán, Lissette Pérez, Alina Álvarez and Ulrich Hengge

    Herpesviridae 2010 1:3

    Published on: 7 December 2010