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Call for papers: Health outcomes, values and guidelines – expanding the scope of HQLO

Current special series and section editors: Dr Jan Brozek, Dr Yaolong Chen, Dr Pablo Alonso Coello, Dr Joerg J Meerpohl, Dr Yuan Zhang, Prof Holger Schünemann of Health and Quality of Life Outcomes invite you to submit to our special series and section: Health outcomes, values and guidelines.

Improving health outcomes is the ultimate goal of recommendations made in health guidelines and other guidance statements. People important outcomes (PIOs), including the relative importance of these outcomes, quality of life assessment, values and preferences and best methods for integrating them in health care guidelines are at the forefront of methodological and clinical practice research. Considering PIOs in the context of other criteria that influence a health care decision to achieve the greatest possible desirable consequences of a health care option is a preeminent goal of a guideline recommendation. The improvement of both the development of guideline recommendations through methodological research and practical application will now be considered for publication in Health and Quality of Life Outcomes, beginning with a special series.

Health and Quality of Life Outcomes will, for this special series, and subsequent issues consider the following articles for publication on guidelines and guideline methodology: clinical, public health and other health related recommendations and guidelines/guidance, including supplementary materials for guidelines, such as Evidence to Decision Frameworks; and, scientific articles describing methodological research and standards to improve the development, dissemination and implementation of guidelines. For future issues of the journal we do also invite editorials and opinion pieces about guideline development.

Submitted guidelines should follow standards set by the Institutes of Medicine and the Guideline International Network and utilize appropriate methods for the development of guidelines such as the GIN-McMaster Guideline Development checklist. These standards include the use of proven approaches to assess the certainty in the evidence and move from evidence to decisions such as the GRADE approach. Authors of guidelines should follow the RIGHT statement (reference to EQUATOR) for reporting of guidelines to achieve high scores on assessment instruments such as the AGREE instrument.

Manuscripts should be formatted according to Health and Quality of Life Outcomes submission guidelines and submitted via the online submission system. All articles in this series will undergo the journal’s full standard peer-review process. In the submission system please make sure the correct collection title is chosen from the “additional information” tab. Please also indicate in the covering letter that the manuscript is to be considered for the ‘Guidelines and guideline methodology’ special series. For further information, please contact the Editors (hqlo@biomedcentral.com).


  1. Heart failure (HF) is a severe and self-limiting syndrome. Its signs and symptoms are believed to predict poorer health-related quality of life scores, which are mainly influenced by deterioration in physical ...

    Authors: Paula Cristina Silva, Omar Pereira de Almeida Neto and Elmiro Santos Resende

    Citation: Health and Quality of Life Outcomes 2021 19:129

    Content type: Research

    Published on:

  2. To evaluate the interaction of depression and anxiety with the development of recurrent pregnancy loss (RPL).

    Authors: Yanxia Wang, Zhaoyan Meng, Jianyin Pei, Liu Qian, Baohong Mao, Yamei Li, Jing Li, Zhirong Dai, Jianing Cao, Chunhua Zhang, Lina Chen, Yuxia Jin and Bin Yi

    Citation: Health and Quality of Life Outcomes 2021 19:78

    Content type: Research

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  3. The Autism Behavior Inventory (ABI) is an observer-reported outcome scale measuring core and associated features of autism spectrum disorder (ASD). Extensive scale development (reported elsewhere) took place, ...

    Authors: Gahan Pandina, Seth Ness, Jeremiah Trudeau, Sonja Stringer, Naomi Knoble, William R. Lenderking and Abigail Bangerter

    Citation: Health and Quality of Life Outcomes 2021 19:26

    Content type: Research

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  4. Dental and oral diseases can have negative impacts on children’s quality of life. The aim of this study was to determine the predictors of oral health-related quality of life (OHRQoL) in the children aged 2–5 ...

    Authors: Masoumeh Abbasi-Shavazi, Elham Mansoorian, Sara Jambarsang, Amene Hosseini-Yekani and Vahid Rahmanian

    Citation: Health and Quality of Life Outcomes 2020 18:384

    Content type: Research

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  5. When curative treatments are no longer available for cancer patients, the aim of treatment is palliative. The emphasis of palliative care is on optimizing quality of life and provided support for patients near...

    Authors: Elham Akhlaghi, Rebecca H. Lehto, Mohsen Torabikhah, Hamid Sharif Nia, Ahmad Taheri, Ehsan Zaboli and Ameneh Yaghoobzadeh

    Citation: Health and Quality of Life Outcomes 2020 18:332

    Content type: Review

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  6. The Tinnitus Functional Index (TFI) is a new diagnostic measure of the functional impact of tinnitus that is also a sensitive measure of treatment-related changes. However, the TFI has not been translated into...

    Authors: Xianren Wang, Ruyan Zeng, Huiwen Zhuang, Qiyang Sun, Zijun Yang, Cangjian Sun and Guanxia Xiong

    Citation: Health and Quality of Life Outcomes 2020 18:272

    Content type: Research

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  7. The prevalence of diabetes mellitus (DM) among patients with chronic kidney disease (CKD) has been increasing in recent years in China. This study aimed to evaluate the association between DM and health-relate...

    Authors: Li Chen, Jinwei Wang, Xiaoyan Huang, Fang Wang, Wei Liang, Yan He, Yumei Liao, Luxia Zhang, Minghui Zhao and Zuying Xiong

    Citation: Health and Quality of Life Outcomes 2020 18:266

    Content type: Research

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  8. Individuals with diabetes mellitus have difficulty solving problems in meaningful occupations and have similar difficulties with self-care regimens. We examined the effects of an occupation-based intervention ...

    Authors: Zeynep Bahadır Ağce and Gamze Ekici

    Citation: Health and Quality of Life Outcomes 2020 18:265

    Content type: Research

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  9. Sleep problems are widespread among college students around the globe, especially in China. This study was designed to investigate the prevalence of poor sleep quality and identify associated factors among col...

    Authors: Yuanyuan Li, Wei Bai, Bo Zhu, Ruixin Duan, Xiao Yu, Wen Xu, Mohan Wang, Wanqing Hua, Weiying Yu, Wenjun Li and Changgui Kou

    Citation: Health and Quality of Life Outcomes 2020 18:210

    Content type: Research

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  10. This study examined the relationship between sociodemographic characteristics and maternal health use from a policy perspective. It aimed to provide an overview of maternal health in Heilongjiang’s rural provi...

    Authors: Kexin Jiang, Libo Liang, Haifeng Wang, Jingqun Li, Yuze Li, Mingli Jiao, Jingfu Mao and Qunhong Wu

    Citation: Health and Quality of Life Outcomes 2020 18:201

    Content type: Research

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  11. During healthcare guideline development, panel members often have implicit, different definitions of health outcomes that can lead to misunderstandings about how important these outcomes are and how to balance...

    Authors: Tejan Baldeh, Zuleika Saz-Parkinson, Paola Muti, Nancy Santesso, Gian Paolo Morgano, Wojtek Wiercioch, Robby Nieuwlaat, Axel Gräwingholt, Mireille Broeders, Stephen Duffy, Solveig Hofvind, Lennarth Nystrom, Lydia Ioannidou-Mouzaka, Sue Warman, Helen McGarrigle, Susan Knox…

    Citation: Health and Quality of Life Outcomes 2020 18:167

    Content type: Research

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  12. Migrants may carry with them communicable and non communicable diseases as they move to the host country. Screening migrants may help in improving their health status and in preventing the spread of infections...

    Authors: Tamara Lotfi, Mohamad I. Itani, Pamela Howeiss, Lama Kilzar, Nesrine A. Rizk and Elie A. Akl

    Citation: Health and Quality of Life Outcomes 2020 18:125

    Content type: Research

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  13. Health Promoting Lifestyle Profile-II (HPLP-II), developed in the West, evaluates 52 health promoting behaviors (HPB) under six subscales. In this study we evaluated the applicability of HPLP-II to assess the ...

    Authors: Nirmala Rathnayake, Gayani Alwis, Janaka Lenora and Sarath Lekamwasam

    Citation: Health and Quality of Life Outcomes 2020 18:122

    Content type: Research

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  14. Psychometric investigations of tools used in the screening of migraine including the migraine screen questionnaire (MS-Q), using an adequate statistical approach is needed. We assessed the psychometric propert...

    Authors: Md. Dilshad Manzar, Unaise Abdul Hameed, Mohammed Salahuddin, Mohammad Yunus Ali Khan, Dejen Nureye, Wakuma Wakene, Majed Alamri, Abdulrhman Albougami, Seithikuruppu R. PandiPerumal and Ahmed S. Bahammam

    Citation: Health and Quality of Life Outcomes 2020 18:113

    Content type: Research

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  15. Population aging is an inevitable trend and previous studies have showed the relationship between social health related factors and health-related quality of life (HR-QOL) in the elderly. The objective of this...

    Authors: Jieming Lu, Zhebin Yu, Xiaocong Zhang, Mengyin Wu, Shujuan Lin, Yao Zhu, Zenghao Xu, Liuqing You, Fang Wei, Mengling Tang, Mingjuan Jin, Jianbing Wang and Kun Chen

    Citation: Health and Quality of Life Outcomes 2020 18:110

    Content type: Research

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  16. Autism Spectrum Disorder (ASD) is a neuro-developmental disorder that affects communication and behavior with a prevalence of approximately 1% worldwide. Health outcomes of interventions for ASD are largely Pa...

    Authors: Gian Paolo Morgano, Francesca Fulceri, Franco Nardocci, Corrado Barbui, Giovanni Ostuzzi, Davide Papola, Laura Maria Fatta, Alice Josephine Fauci, Daniela Coclite, Antonello Napoletano, Franco De Crescenzo, Gian Loreto D’Alò, Laura Amato, Michela Cinquini, Primiano Iannone, Holger Jens Schünemann…

    Citation: Health and Quality of Life Outcomes 2020 18:81

    Content type: Research

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  17. Vitiligo is caused by partial or complete destruction of melanocytes in the affected skin area and influences the patient’s quality of life. Besides physical involvement, vitiligo patients experience a high le...

    Authors: Nasrin Hamidizadeh, Sara Ranjbar, Ahmad Ghanizadeh, Mohammad Mahdi Parvizi, Peyman Jafari and Farhad Handjani

    Citation: Health and Quality of Life Outcomes 2020 18:20

    Content type: Research

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  18. Due to high prevalence of diabetes and its complications, evaluating of the patients’ quality of life is critical. EQ-5D-5 L is a valid tool for assessing the quality of life in chronic diseases including diab...

    Authors: Mohammad Reza Abedini, Bita Bijari, Zahra Miri, Fatemeh Shakhs Emampour and Ali Abbasi

    Citation: Health and Quality of Life Outcomes 2020 18:18

    Content type: Research

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  19. Research on the effects of sedentary behavior on the health-related quality of life (HRQoL) of the elderly is limited. The present study aimed to determine the association between sedentary behavior and the HR...

    Authors: Yujeong Kim and Eunmi Lee

    Citation: Health and Quality of Life Outcomes 2019 17:131

    Content type: Research

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  20. The incidence and mortality rates of cancer have been increasing in developing countries, particularly in Asia. Therefore to provide optimal comprehensive care to the cancer patients, the care plan must focus ...

    Authors: Xin-Shuang Zhao, Hong-Yun Wang, Luo-Ling Zhang, Yan-Hua Liu, Hai-Yan Chen and Ying Wang

    Citation: Health and Quality of Life Outcomes 2019 17:102

    Content type: Research

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  21. Low health literacy often has an association with poor health outcomes such as low levels of self-efficacy, increased mortality, poor health status and reduced quality of life (QOL). The aim of the study was t...

    Authors: Mengyun Zheng, Hui Jin, Naiyang Shi, Chunxiao Duan, Donglei Wang, Xiaoge Yu and Xiaoning Li

    Citation: Health and Quality of Life Outcomes 2018 16:201

    Content type: Review

    Published on:

  22. The Pain Disability Index (PDI) is a widely-used instrument to measure pain-related disability. The aim of this study was to assess the responsiveness and interpretation of change score of the PDI in patients ...

    Authors: T. Beemster, C. van Bennekom, J. van Velzen, M. Reneman and M. Frings-Dresen

    Citation: Health and Quality of Life Outcomes 2018 16:182

    Content type: Research

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  23. Generic assessments are less responsive to subtle changes due to specific diseases, making it challenging to fully understand the impact of pulmonary tuberculosis (TB) on patient’s quality of life (QOL).

    Authors: Yanchun Sun, Zheng Yang, Chonghua Wan, Chuanzhi Xu, Liuping Chen, Lin Xu, Xiaoqing Zhang and Fei Yan

    Citation: Health and Quality of Life Outcomes 2018 16:137

    Content type: Research

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  24. Despite the high prevalence of lymphedema in Iranian breast cancer patients, there is no valid instrument for measuring quality of life in this population. The aim of this study was to assess reliability and v...

    Authors: Shahpar Haghighat, Ali Montazeri, Farid Zayeri, Mandana Ebrahimi and Jan Weiss

    Citation: Health and Quality of Life Outcomes 2018 16:132

    Content type: Research

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  25. Young adult patients with cancer have to deal with their disease in an eventful phase of life. A common side effect of cancer and its treatment is cancer-related fatigue (CRF), a phenomenon which can thwart su...

    Authors: Michael Friedrich, Erik Nowe, Dirk Hofmeister, Susanne Kuhnt, Katja Leuteritz, Annekathrin Sender, Yve Stöbel-Richter and Kristina Geue

    Citation: Health and Quality of Life Outcomes 2018 16:125

    Content type: Research

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  26. International reports indicating that around 10–50% of health care staff are exposed to violence every year; in certain settings, this rate might reach over 85%. Evidence has shown that people who experience p...

    Authors: Peng Li, Kai Xing, Hong Qiao, Huiying Fang, Hongkun Ma, Mingli Jiao, Yanhua Hao, Ye Li, Libo Liang, Lijun Gao, Zheng Kang, Yu Cui, Hong Sun, Qunhong Wu and Ming Liu

    Citation: Health and Quality of Life Outcomes 2018 16:117

    Content type: Research

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  27. Quality of life can be used to measure the effect of intervention on health related conditions. Health insurance contributes positive effect on availability of medical supplies and empowerment of women and chi...

    Authors: Teklemichael Gebru and Kifle Lentiro

    Citation: Health and Quality of Life Outcomes 2018 16:110

    Content type: Research

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  28. In China, the problems of population aging and empty nesting have become important issues which will affect the social stability and economic development. The aim of this study was to explore the health promot...

    Authors: Chichen Zhang, Ruifang Zhu, Jiao Lu, Yaqing Xue, Lihong Hou, Mimi Li, Xiao Zheng, Tingzhong Yang and Jianzhong Zheng

    Citation: Health and Quality of Life Outcomes 2018 16:103

    Content type: Research

    Published on:

  29. There are various instruments and methods to evaluate spinal health and functional status. Whole-spine patient reported outcome (PRO) measures, such as the Spine Functional Index (SFI), assess the spine from t...

    Authors: Hamid Reza Mokhtarinia, Azadeh Hosseini, Azam Maleki-Ghahfarokhi, Charles Philip Gabel and Majid Zohrabi

    Citation: Health and Quality of Life Outcomes 2018 16:95

    Content type: Research

    Published on:

  30. The Pittsburgh Sleep Quality Index (PSQI) dimensionality is much debated, with the greatest number of reported factor structures. Therefore, this review appraised the methodologies of studies investigating the...

    Authors: Md Dilshad Manzar, Ahmed S. BaHammam, Unaise Abdul Hameed, David Warren Spence, Seithikurippu R. Pandi-Perumal, Adam Moscovitch and David L. Streiner

    Citation: Health and Quality of Life Outcomes 2018 16:89

    Content type: Review

    Published on:

  31. Infertility can cause psychological distress and has a negative impact on quality of life (QoL). There have been no studies investigating the effect of depression on QoL in infertile couples at the dyadic leve...

    Authors: Saman Maroufizadeh, Mostafa Hosseini, Abbas Rahimi Foroushani, Reza Omani-Samani and Payam Amini

    Citation: Health and Quality of Life Outcomes 2018 16:73

    Content type: Research

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  32. With the elderly population comprising an increasing large proportion of society, a valid and reliable measure of social health in the elderly is indispensable for a comprehensive health assessment. The object...

    Authors: Chengzhen Bao, Zhebin Yu, Xuefen Yin, Zhen Chen, Lu Meng, Weibo Yang, Xueyu Chen, Mingjuan Jin, Jianbing Wang, Mengling Tang and Kun Chen

    Citation: Health and Quality of Life Outcomes 2018 16:67

    Content type: Research

    Published on:

  33. In Ethiopia assuring the satisfaction of health care provider with their job is a major challenging problem. Job satisfaction is a worker’s emotional response to different job related factors resulting in find...

    Authors: Kalkidan Temesgen, Moges Wubie Aycheh and Cheru Tesema Leshargie

    Citation: Health and Quality of Life Outcomes 2018 16:65

    Content type: Research

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  34. To assess the influence of combined training on pain, fatigue, maximal oxygen uptake (VO2 max), body mass index (BMI), flexibility, and strength in patients with breast cancer.

    Authors: Andréa Dias Reis, Paula Tamara Vieira Teixeira Pereira, Renata Rodrigues Diniz, Jurema Gonçalves Lopes de Castro Filha, Alcione Miranda dos Santos, Bianca Trovello Ramallo, Florentino Assenço Alves Filho, Francisco Navarro and João Batista Santos Garcia

    Citation: Health and Quality of Life Outcomes 2018 16:58

    Content type: Research

    Published on:

  35. Patients with prostate cancer (PC) may be ready to make trade-offs between their quantity and their quality of life. For instance, elderly patients may prefer the absence of treatment if it is associated with ...

    Authors: Yohann Foucher, Marine Lorent, Philippe Tessier, Stéphane Supiot, Véronique Sébille and Etienne Dantan

    Citation: Health and Quality of Life Outcomes 2018 16:40

    Content type: Review

    Published on:

  36. Several diseases may lead to the need for liver transplantation due to progressive organ damage until the onset of cirrhosis, resulting in changes in interpersonal relationships. Social Support for transplant ...

    Authors: Clerison Stelvio Garcia, Agnaldo Soares Lima, Ehideé Isabel Gómez La-Rotta and Ilka de Fátima Santana Ferreira Boin

    Citation: Health and Quality of Life Outcomes 2018 16:35

    Content type: Research

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  37. To evaluate and analyse the factors associated with health-related quality of life (HR-QoL) in the Korean population aged 50 years and older.

    Authors: Kyoung Min Kwon, Jung Soo Lee, Na Eun Jeon and Yeo Hyung Kim

    Citation: Health and Quality of Life Outcomes 2017 15:243

    Content type: Research

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  38. Quality of life must be one of the main purposes for the treatment of drug users, requiring a better understanding of the association between the quality of life and the severity of dependency. This study aime...

    Authors: Selva Rios Campêlo, Maria Alves Barbosa, Danilo Rocha Dias, Camila Cardoso Caixeta, Cláudio Rodrigues Leles and Celmo Celeno Porto

    Citation: Health and Quality of Life Outcomes 2017 15:223

    Content type: Research

    Published on:

  39. Women treated for breast cancer are followed-up for monitoring of treatment effectiveness and for detecting recurrences at an early stage. The type of follow-up received may affect women’s reassurance and impa...

    Authors: Alessandra Lafranconi, Liisa Pylkkänen, Silvia Deandrea, Anke Bramesfeld, Donata Lerda, Luciana Neamțiu, Zuleika Saz-Parkinson, Margarita Posso, David Rigau, Ivan Sola, Pablo Alonso-Coello and Maria José Martinez-Zapata

    Citation: Health and Quality of Life Outcomes 2017 15:206

    Content type: Research

    Published on:

  40. It has been hypothesized that adaptation of health practice guidelines to the local setting is expected to improve their uptake and implementation while cutting on required resources. We recently adapted the p...

    Authors: Andrea Darzi, Manale Harfouche, Thurayya Arayssi, Samar Alemadi, Khalid A. Alnaqbi, Humeira Badsha, Farida Al Balushi, Bassel Elzorkany, Hussein Halabi, Mohammed Hamoudeh, Wissam Hazer, Basel Masri, Mohammed A. Omair, Imad Uthman, Nelly Ziade, Jasvinder A. Singh…

    Citation: Health and Quality of Life Outcomes 2017 15:183

    Content type: Research

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    The Correction to this article has been published in Health and Quality of Life Outcomes 2017 15:214

  41. Shoulder pain is a common musculoskeletal disorder in Chinese population, which affects more than 1,3 billion individuals. To the best of our knowledge, there has been no available Chinese-language version of ...

    Authors: Min Yao, Long Yang, Zuo-yuan Cao, Shao-dan Cheng, Shuang-lin Tian, Yue-li Sun, Jing Wang, Bao-ping Xu, Xiao-chun Hu, Yong-jun Wang, Ying Zhang and Xue-jun Cui

    Citation: Health and Quality of Life Outcomes 2017 15:178

    Content type: Short report

    Published on:

  42. The Center for Epidemiological Studies Depression Scale (CES-D) is an instrument that is commonly used to screen for depression in patients with chronic disease, but the characteristics of the CES-D in adults ...

    Authors: Ju Ryoung Moon, June Huh, Jinyoung Song, I-Seok Kang, Seung Woo Park, Sung-A Chang, Ji-Hyuk Yang and Tae-Gook Jun

    Citation: Health and Quality of Life Outcomes 2017 15:176

    Content type: Research

    Published on:

  43. This paper investigates the properties and performance of the two generic measures, EQ-5D and SF-12, for Health-Related Quality of Life (HRQoL) assessments of pregnant women living with HIV in Kunming City, Yi...

    Authors: Xiaowen Wang, Guangping Guo, Ling Zhou, Jiarui Zheng, Xiumin Liang, Zhanqin Li, Hongzhuan Luo, Yuyan Yang, Liyuan Yang, Ting Tan, Jun Yu and Lin Lu

    Citation: Health and Quality of Life Outcomes 2017 15:158

    Content type: Research

    Published on:

  44. Identifying scientific literature addressing patients’ views and preferences is complex due to the wide range of studies that can be informative and the poor indexing of this evidence. Given the lack of guidan...

    Authors: Anna Selva, Ivan Solà, Yuan Zhang, Hector Pardo-Hernandez, R. Brian Haynes, Laura Martínez García, Tamara Navarro, Holger Schünemann and Pablo Alonso-Coello

    Citation: Health and Quality of Life Outcomes 2017 15:126

    Content type: Research

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  45. Due to increasing export of labor service, many children following their parents leave from rural areas to urban areas in China. These migrant children might have psychological stress and lower quality of life...

    Authors: Fengjiao Xu, Haiyan Xing, Wei Yu, Sanmei Chen and Hui Li

    Citation: Health and Quality of Life Outcomes 2017 15:100

    Content type: Research

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  46. Health-related quality of life (HRQoL) is an important outcome measure among HIV infected patients receiving antiretroviral therapy (ART). When HIV infected patients coinfected with Visceral Leishmaniasis (VL)...

    Authors: Mekuriaw Alemayehu, Mamo Wubshet, Nebiyu Mesfin, Aschalew Tamiru and Abebaw Gebayehu

    Citation: Health and Quality of Life Outcomes 2017 15:65

    Content type: Research

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  47. There are diverse opinions and confusion about defining and including patient values and preferences (i.e. the importance people place on the health outcomes) in the guideline development processes. This artic...

    Authors: Yuan Zhang, Pablo Alonso Coello, Jan Brożek, Wojtek Wiercioch, Itziar Etxeandia-Ikobaltzeta, Elie A. Akl, Joerg J. Meerpohl, Waleed Alhazzani, Alonso Carrasco-Labra, Rebecca L. Morgan, Reem A. Mustafa, John J. Riva, Ainsley Moore, Juan José Yepes-Nuñez, Carlos Cuello-Garcia, Zulfa AlRayees…

    Citation: Health and Quality of Life Outcomes 2017 15:52

    Content type: Research

    Published on: