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The Greppi Award

The Italian Society for the Study of Headaches sponsors an award in memory of Enrico Greppi, pioneer and expert in the study of headache.

The award is granted to the best unpublished original paper dealing with clinical, epidemiological, genetic, pathophysiological or therapeutic aspects of headache. 

This thematic series collects all the articles which have been awarded with the Enrico Greppi award since 2000. 


  1. Migraine is a complex neurological disorder that is considered the most common disabling brain disorder affecting 14 % of people worldwide. The present study sought to infer potential causal relationships betw...

    Authors: Luis M. García-Marín, Adrián I. Campos, Nicholas G. Martin, Gabriel Cuéllar-Partida and Miguel E. Rentería

    Citation: The Journal of Headache and Pain 2021 22:66

    Content type: Research article

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  2. Despite the growing body of advanced studies investigating the neuronal correlates of pain processing in patients with migraine without aura (MwoA), only few similar studies have been conducted in patients wit...

    Authors: Antonio Russo, Alessandro Tessitore, Marcello Silvestro, Federica Di Nardo, Francesca Trojsi, Teresa Del Santo, Rosa De Micco, Fabrizio Esposito and Gioacchino Tedeschi

    Citation: The Journal of Headache and Pain 2019 20:46

    Content type: Research article

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  3. Migraine attacks might be triggered by a disruption of cerebral homeostasis. During the interictal period migraine patients are characterized by abnormal sensory information processing, but this functional abn...

    Authors: Marco Lisicki, Kevin D’Ostilio, Gianluca Coppola, Felix Scholtes, Alain Maertens de Noordhout, Vincenzo Parisi, Jean Schoenen and Delphine Magis

    Citation: The Journal of Headache and Pain 2018 19:49

    Content type: Research article

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  4. Relatively little is known about the stability of a diagnosis of episodic migraine (EM) or chronic migraine (CM) over time. This study examines natural fluctuations in self-reported headache frequency as well ...

    Authors: Daniel Serrano, Richard B. Lipton, Ann I. Scher, Michael L. Reed, Walter (Buzz) F. Stewart, Aubrey Manack Adams and Dawn C. Buse

    Citation: The Journal of Headache and Pain 2017 18:101

    Content type: Research article

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  5. Migraine and Cluster Headache (CH) are two primary headaches with severe disease burden. The disease expression and the mechanisms involved are poorly known. In some attacks of migraine and in most attacks of ...

    Authors: Anna Steinberg, Simona D Frederiksen, Frank W Blixt, Karin Warfvinge and Lars Edvinsson

    Citation: The Journal of Headache and Pain 2016 17:78

    Content type: Research article

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    The Erratum to this article has been published in The Journal of Headache and Pain 2016 17:86

  6. Optimal management of patients with classical trigeminal neuralgia (TN) requires specific treatment programs and close collaboration between medical, radiological and surgical specialties. Organization of such...

    Authors: Tone Heinskou, Stine Maarbjerg, Per Rochat, Frauke Wolfram, Rigmor Højland Jensen and Lars Bendtsen

    Citation: The Journal of Headache and Pain 2015 16:66

    Content type: Research article

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  7. Menstrual migraine (MM) encompasses pure menstrual migraine (PMM) and menstrually-related migraine (MRM). This study was aimed at investigating genetic variants that are potentially related to MM, specifically...

    Authors: Astrid J Rodriguez-Acevedo, Robert A Smith, Bishakha Roy, Heidi Sutherland, Rod A Lea, Alison Frith, E Anne MacGregor and Lyn R Griffiths

    Citation: The Journal of Headache and Pain 2014 15:62

    Content type: Research article

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  8. Nitric oxide (NO) is thought to play an important role in the pathophysiology of migraine. Infusion of the nitrovasodilator glyceroltrinitrate (nitroglycerin, GTN), which mobilizes NO in the organism, is an ap...

    Authors: Kristin Seiler, Judith I Nusser, Jochen K Lennerz, Winfried L Neuhuber and Karl Messlinger

    Citation: The Journal of Headache and Pain 2013 14:74

    Content type: Research article

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  9. The aim of this study was to assess the role of depression as a predictor of new onset of chronic migraine (CM) among persons with episodic migraine (EM). The American Migraine Prevalence and Prevention (AMPP)...

    Authors: Sait Ashina, Daniel Serrano, Richard B. Lipton, Morris Maizels, Aubrey N. Manack, Catherine C. Turkel, Michael L. Reed and Dawn C. Buse

    Citation: The Journal of Headache and Pain 2012 13:479

    Content type: GREPPI AWARD 2012

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  10. Non-steroidal anti-inflammatory drugs (NSAIDs) that act as cyclo-oxygenase (COX) inhibitors are commonly used in the treatment of a range of headache disorders, although their mechanism of action is unclear. I...

    Authors: Oliver Summ, Anna P. Andreou, Simon Akerman and Peter J. Goadsby

    Citation: The Journal of Headache and Pain 2010 11:263

    Content type: Original

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  11. Headaches provoked by cough, prolonged physical exercise and sexual activity have not been studied prospectively, clinically and neuroradiologically. Our aim was to delimitate characteristics, etiology, respon...

    Authors: Julio Pascual, Andrés González-Mandly, Rubén Martín and Agustín Oterino

    Citation: The Journal of Headache and Pain 2008 9:63

    Content type: Enrico Greppi Award 2008

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  12. The objective was to investigate the importance of genetic and environmental factors for infrequent episodic, frequent episodic and chronic tension-type headache. Twin pairs recruited from the population-based...

    Authors: M. B. Russell, J. Šaltytš-Benth and N. Levi

    Citation: The Journal of Headache and Pain 2006 7:299

    Content type: GREPPI-SICUTERI AWARD 2006

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  13. The objective was to examine the main genetic and environmental architecture of migraine in the Screening Across Lifetime of Twin (SALT) Study as a function of definition. We performed a quantitative genetic s...

    Authors: Dan A. Svensson, Elisabet Waldenlind, Karl Ekbom and Nancy L. Pedersen

    Citation: The Journal of Headache and Pain 2004 5:96

    Content type: ENRICO GREPPI AWARD

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  14. Little has been done to investigate the biochemical basis of chronic daily headache (CDH). Our group has recently demonstrated an increase in the cerebrospinal fluid (CSF) levels of nerve growth factor (NGF) ...

    Authors: Paola Sarchielli, Andrea Alberti, Beatrice Gallai, Francesca Coppola, Antonio Baldi, Ardesio Floridi and Virgilio Gallai

    Citation: The Journal of Headache and Pain 2002 3:00030

    Content type: ENRICO GREPPI AWARD

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  15. Using BOLD-fMRI we have previously documented activation of the red nucleus (RN) and substantia nigra (SN) during spontaneously and visually activated migraine headache. These observations prompted us to stud...

    Authors: Vijaya Nagesh, Michael Welch, Sheena K. Aurora, Neil Gelman and Shanthi Gopal

    Citation: The Journal of Headache and Pain 2000 1:00010067.10194

    Content type: Enrico Greppi award paper

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