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Article collection: Genotoxicity Tests

Here's a collection of highlighted articles recommended by the editors and the publisher. Be sure to bookmark this page, as it will be with new contents. 

This is a non-sponsored collection assembled by the Editor-in-Chief Prof. Masami Yamada, Genes and Environment

  1. The PIGRET assay is one of the Pig-a assays targeting reticulocytes (RETs), an in vivo genotoxicity evaluation method using flow cytometry with endogenous reporter glycosylphosphatidylinositol anchor protein. The...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2021 43:10
  2. The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity. I...

    Authors: Shuichi Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, Hajime Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, Akihisa Maeda, Yukari Terashima, Wakako Ohyama, Takeshi Morita and Makoto Hayashi
    Citation: Genes and Environment 2019 41:13
  3. The Pig-a assay, a promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs) that are deficient in glycosylphosphatidylinositol anchor protein. Various ...

    Authors: Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto and Katsuyoshi Horibata
    Citation: Genes and Environment 2019 41:5
  4. Use of Quantitative Structure-Activity Relationships ((Q)SAR) prediction tools has been increasing since the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use ...

    Authors: Masayuki Mishima, Tsuneo Hashizume, Yu Haranosono, Yusuke Nagato, Kentaro Takeshita, Junichi Fukuchi and Masamitsu Homma
    Citation: Genes and Environment 2018 40:19
  5. A large-scale study was conducted by multiple laboratories affiliated with the Japanese Environmental Mutagen Society and the Bacterial Mutagenicity Study Group to investigate possible proficiency indicators f...

    Authors: Masayuki Kato, Kei-ichi Sugiyama, Toshiro Fukushima, Yasuyoshi Miura, Takumi Awogi, Shigetomo Hikosaka, Kumiko Kawakami, Madoka Nakajima, Masato Nakamura, Hajime Sui, Kumiko Watanabe and Atsushi Hakura
    Citation: Genes and Environment 2018 40:7
  6. The evolution of methods to assess genotoxicity of test compounds is thought to be one of the important subjects in The Japanese Environmental and Mutagen Society (JEMS). In 1970, the Ministry of Education of...

    Authors: Toshio Sofuni
    Citation: Genes and Environment 2017 39:15
  7. Rats are a standard experimental animal for cancer bioassay and toxicological research for chemicals. Although the genetic analyses were behind mice, rats have been more frequently used for toxicological resea...

    Authors: Takehiko Nohmi, Kenichi Masumura and Naomi Toyoda-Hokaiwado
    Citation: Genes and Environment 2017 39:11