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Genomics of COVID-19: Molecular Mechanisms Going from Susceptibility to Severity of the Disease


The current COVID-19 pandemic has highlighted the importance of science and medicine, specifically public health, in our modern societies. Countries have taken different approaches to the pandemic. Science and medicine will play an important role in our way forward in tackling COVID-19. Specifically, genetics and genomics will be central in discovering variations in virus strains and their impact on patients’ outcome, the hosts’ ability to fend off the virus and the severity of disease in patients. Furthermore, the question of long-term immunity to COVID-19 may have a genetic and genomic basis which should be investigated. Some of these human genetics and genomics investigations will undoubtedly be suitable for publication in Human Genomics. We expressly welcome submissions of manuscripts on such subjects.

Guest Editors

Giuseppe Novelli, University of Rome Tor Vergata, Italy; Juergen Reichardt,  James Cook University, Australia.

  1. The present study investigated two single nucleotide polymorphisms (SNPs)—rs479200 and rs516651 in the host EGLN1/PHD2 gene for their association with COVID-19 severity. A retrospective cohort of 158 COVID-19 pat...

    Authors: Renuka Harit, Sajal De, Piyoosh Kumar Singh, Deepika Kashyap, Manish Kumar, Dibakar Sahu, Chander Prakash Yadav, Mradul Mohan, Vineeta Singh, Ram Singh Tomar, Kailash C. Pandey and Kapil Vashisht
    Citation: Human Genomics 2024 18:7

    The Correction to this article has been published in Human Genomics 2024 18:17

  2. Clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outcomes could be influenced by genetic polymorphisms in angiotensin I-converting enzyme (ACE1) and ACE2. This study aims to exami...

    Authors: Farzaneh Sheikhian, Sahar Sadeghi Mofrad, Samira Tarashi, Morteza Ghazanfari Jajin, Fatemeh Sakhaee, Iraj Ahmadi, Enayat Anvari, Mojgan Sheikhpour and Abolfazl Fateh
    Citation: Human Genomics 2023 17:54
  3. Individuals infected with SARS-CoV-2 vary greatly in their disease severity, ranging from asymptomatic infection to severe disease. The regulation of gene expression is an important mechanism in the host immun...

    Authors: T. Gjorgjieva, A. Chaloemtoem, T. Shahin, O. Bayaraa, M. M. Dieng, M. Alshaikh, M. Abdalbaqi, J. Del Monte, G. Begum, C. Leonor, V. Manikandan, N. Drou, M. Arshad, M. Arnoux, N. Kumar, A. Jabari…
    Citation: Human Genomics 2023 17:49
  4. The use of molecular biomarkers for COVID-19 remains unconclusive. The application of a molecular biomarker in combination with clinical ones that could help classifying aggressive patients in first steps of t...

    Authors: Silvia Martinez-Diz, Carmen Maria Morales-Álvarez, Yarmila Garcia-Iglesias, Juan Miguel Guerrero-González, Catalina Romero-Cachinero, Jose María González-Cabezuelo, Francisco Javier Fernandez-Rosado, Verónica Arenas-Rodríguez, Rocío Lopez-Cintas, Maria Jesús Alvarez-Cubero and Luis Javier Martinez-Gonzalez
    Citation: Human Genomics 2023 17:50
  5. Human angiotensin-converting enzyme 2 (ACE2), a type I transmembrane receptor physiologically acting as a carboxypeptidase enzyme within the renin-angiotensin system (RAS), is a critical mediator of infection ...

    Authors: Sally Badawi, Feda E. Mohamed, Nesreen R. Alkhofash, Anne John, Amanat Ali and Bassam R. Ali
    Citation: Human Genomics 2022 16:35
  6. The tripartite motif containing (TRIM)-22 participates in innate immune responses and exhibits antiviral activities. The present study aimed to assess of the relationship between TRIM22 single-nucleotide polymorp...

    Authors: Nidhal Raheem Juhi Al-Kaabi, Sepideh Chodari Khameneh, Mohadeseh Montazeri, Mahsa Mardasi, Jalal Mosayebi Amroabadi, Fatemeh Sakhaee and Abolfazl Fateh
    Citation: Human Genomics 2022 16:33
  7. COVID-19, which is caused by the SARS-CoV-2, has ravaged the world for the past 2 years. Here, we review the current state of research into the disease with focus on its history, human genetics and genomics an...

    Authors: Michela Biancolella, Vito Luigi Colona, Ruty Mehrian-Shai, Jessica Lee Watt, Lucio Luzzatto, Giuseppe Novelli and Juergen K. V. Reichardt
    Citation: Human Genomics 2022 16:19
  8. Coronavirus disease 2019 (COVID-19) is a global health problem that causes millions of deaths worldwide. The clinical manifestation of COVID-19 widely varies from asymptomatic infection to severe pneumonia and...

    Authors: Laksmi Wulandari, Berliana Hamidah, Cennikon Pakpahan, Nevy Shinta Damayanti, Neneng Dewi Kurniati, Christophorus Oetama Adiatmaja, Monica Rizky Wigianita, Soedarsono, Dominicus Husada, Damayanti Tinduh, Cita Rosita Sigit Prakoeswa, Anang Endaryanto, Ni Nyoman Tri Puspaningsih, Yasuko Mori, Maria Inge Lusida, Kazufumi Shimizu…
    Citation: Human Genomics 2021 15:29
  9. COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organiza...

    Authors: Giuseppe Novelli, Michela Biancolella, Ruty Mehrian-Shai, Vito Luigi Colona, Anderson F. Brito, Nathan D. Grubaugh, Vasilis Vasiliou, Lucio Luzzatto and Juergen K. V. Reichardt
    Citation: Human Genomics 2021 15:27

    The Editorial to this article has been published in Human Genomics 2021 15:57

  10. Mathematical approaches have been for decades used to probe the structure of nucleotide sequences. This has led to the development of Bioinformatics. In this exploratory work, a novel mathematical method is ap...

    Authors: Anastasios A. Tsonis, Geli Wang, Lvyi Zhang, Wenxu Lu, Aristotle Kayafas and Katia Del Rio-Tsonis
    Citation: Human Genomics 2021 15:26

    The Correction to this article has been published in Human Genomics 2021 15:31

  11. SARS-CoV-2 has spread rapidly across the world and is negatively impacting the global human population. COVID-19 patients display a wide variety of symptoms and clinical outcomes, including those attributed to...

    Authors: Manci Li, Luca Schifanella and Peter A. Larsen
    Citation: Human Genomics 2021 15:2
  12. The COVID-19 pandemic is sweeping the world and will feature prominently in all our lives for months and most likely for years to come. We review here the current state 6 months into the declared pandemic. Spe...

    Authors: Giuseppe Novelli, Michela Biancolella, Ruty Mehrian-Shai, Caroline Erickson, Krystal J. Godri Pollitt, Vasilis Vasiliou, Jessica Watt and Juergen K. V. Reichardt
    Citation: Human Genomics 2020 14:48
  13. It is crucial to use the wealth of information emerging from the ongoing SARS-CoV-2 pandemic and confront COVID-19 with a rational approach. There are proactive steps to prevent and fight COVID-19. Management ...

    Authors: Ruty Mehrian-Shai
    Citation: Human Genomics 2020 14:47
  14. The COVID-19 pandemic has strengthened the interest in the biological mechanisms underlying the complex interplay between infectious agents and the human host. The spectrum of phenotypes associated with the SA...

    Authors: Emilio Di Maria, Andrea Latini, Paola Borgiani and Giuseppe Novelli
    Citation: Human Genomics 2020 14:30
  15. Coronaviruses (CoV) are a large family of viruses that are common in humans and many animal species. Animal coronaviruses rarely infect humans with the exceptions of the Middle East respiratory syndrome (

    Authors: Antonio Novelli, Michela Biancolella, Paola Borgiani, Dario Cocciadiferro, Vito Luigi Colona, Maria Rosaria D’Apice, Paola Rogliani, Salvatore Zaffina, Francesca Leonardis, Andrea Campana, Massimiliano Raponi, Massimo Andreoni, Sandro Grelli and Giuseppe Novelli
    Citation: Human Genomics 2020 14:29
  16. The recent coronavirus disease (COVID-19), caused by SARS-CoV-2, is inarguably the most challenging coronavirus outbreak relative to the previous outbreaks involving SARS-CoV and MERS-CoV. With the number of C...

    Authors: Krystal J. Godri Pollitt, Jordan Peccia, Albert I. Ko, Naftali Kaminski, Charles S. Dela Cruz, Daniel W. Nebert, Juergen K.V. Reichardt, David C. Thompson and Vasilis Vasiliou
    Citation: Human Genomics 2020 14:17