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Genome Maintenance and Cancer

  1. Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is...

    Authors: Wenjun Liu, Anna Palovcak, Fang Li, Alyan Zafar, Fenghua Yuan and Yanbin Zhang
    Citation: Cell & Bioscience 2020 10:39
  2. Poly(ADP-ribose) polymerase (PARP) inhibitors represent one of the successful novel approaches to targeted cancer treatment. Indeed, the US Food and Drug Administration (FDA) has recently approved PARP inhibit...

    Authors: Mausam Patel, Somaira Nowsheen, Sanjay Maraboyina and Fen Xia
    Citation: Cell & Bioscience 2020 10:35
  3. Common fragile sites (CFSs) are large chromosomal regions that exhibit breakage on metaphase chromosomes upon replication stress. They become preferentially unstable at the early stage of cancer development an...

    Authors: Shibo Li and Xiaohua Wu
    Citation: Cell & Bioscience 2020 10:29
  4. Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of gen...

    Authors: Zhongxing Sun, Yanjun Zhang, Junqi Jia, Yuan Fang, Yin Tang, Hongfei Wu and Dong Fang
    Citation: Cell & Bioscience 2020 10:9
  5. Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apo...

    Authors: Muzaffer Ahmad Kassab, Lily L. Yu and Xiaochun Yu
    Citation: Cell & Bioscience 2020 10:7
  6. When a protein is covalently and irreversibly bound to DNA (i.e., a DNA–protein cross-link [DPC]), it may obstruct any DNA-based transaction, such as transcription and replication. DPC formation is very common...

    Authors: Huimin Zhang, Yun Xiong and Junjie Chen
    Citation: Cell & Bioscience 2020 10:3