Genome Medicine is pleased to present a special issue entitled ‘From genome integrity to cancer: mechanisms and translational opportunities’. Next-generation sequencing and genomic approaches are revealing the mechanisms underlying genome integrity and how they are compromised in age-related diseases and cancer; this information can guide precision medicine. This issue captures the advances in understanding mutational processes and signatures, genome instability, cancer evolution, tumor heterogeneity, immune escape and resistance to therapies.
This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editor declares that they have no competing interests. The Guest Editor serves an advisory role to guide the scope of the special issue and commissioned content; final editorial decisions lie with the Editor.