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Call for papers: From genome integrity to cancer

Guest editor: Dr Serena Nik-Zainal

New Content ItemGenome Medicine is pleased to announce a special issue entitled From genome integrity to cancer: mechanisms and translational opportunities for publication in Fall 2018, guest edited by Dr Serena Nik-Zainal from the University of Cambridge. Next-generation sequencing and genomic approaches are revealing the mechanisms underlying genome integrity and how they are compromised in age-related diseases and cancer; this information can guide precision medicine. The issue will capture advances in understanding mutational processes and signatures, genome instability, cancer evolution, tumor heterogeneity, immune escape and resistance to therapies.

We are now inviting the submission of Research, Method and Software manuscripts of outstanding interest describing advances in understanding genome integrity and the transition to cancer in the context of translational and clinical research on the following topics:

- Mutational patterns and signatures (incl. technologies and tools for detection)
- Tumor evolution and immune evasion
- DNA damage repair deficiencies and response pathways (incl. excision repair pathways, double stranded breaks repair pathways)
- Mutagenic processes (incl. intrinsic and extrinsic stressors)
- Germline/predisposing mutations
- Genomic instability (incl. chromosomal instability, microsatellite instability, RNA integrity)
- Immune recognition (including neoantigen detection, response and resistance to immunotherapy)
- Epigenome integrity
- Somatic mutations, aging and cancer
- Synthetic lethality
- Risk, prognosis prediction, and patient stratification
- Cancer diagnostics and precision therapies
- Genome editing and model systems  (incl. iPSCs and organoids)

The deadline for submissions has extended to 20 August 2018. To submit your manuscript, please use Genome Medicine’s online submission system. Please indicate in your covering letter that you would like the article to be considered for the ‘Genome integrity to cancer’ special issue. If you would like to enquire about the suitability of a study for consideration, please email

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