Call for papers - Genome editing and cancer

Guest Editors

Emanuel Gonçalves, PhD, Instituto Superior Técnico (IST), Universidade de Lisboa, Portugal
Xueqiu Lin, PhD, Fred Hutchinson Cancer Center, USA

Submission Status: Open | Submission Deadline: 8 February 2025

Genome Biology is calling for submissions to our Collection on key genetic determinants and functional consequences of genome editing interventions in the context of cancer.

New Content Item This Collection supports and amplifies research related to SDG 3: Good Health and Well-being.

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Meet the Guest Editors

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Emanuel Gonçalves, PhD, Instituto Superior Técnico (IST), Universidade de Lisboa, Portugal

Emanuel Gonçalves is an Assistant Professor at Instituto Superior Técnico (IST), University of Lisbon, and an Integrated Researcher at INESC-ID. Previously, he was a post-doctoral fellow at the Sanger Institute and holds a PhD in Systems Biology (2017) from the University of Cambridge and the European Bioinformatics Institute (EMBL-EBI). Emanuel remains engaged with the Cancer Dependency Map and is advancing research in deep learning and the integration of cancer multi-omics and functional genomic screens.

Xueqiu Lin, PhD, Fred Hutchinson Cancer Center, USA

Dr Xueqiu Lin is an Assistant Professor in the computational biology program at Fred Hutchinson Cancer Center. Her research interest focuses on the development and application of computational algorithms and CRISPR functional screening to uncover the regulatory logics in oncogenic regulatory networks. Among the achievements, Dr Lin is credited with the discovery of multi-layer epistasis enhancer network for the robustness of oncogene expression, and the novel utilization of oncogenic networks to interpret the epistasis effects among non-coding variants on cancer risk. To further translate the cancer functional genomics, the Lin lab is actively developing cancer risk prediction schemes and epigenomic targeted therapy by using a combination of CRISPR screening, deep learning, and statistical modeling.

About the collection

Genome Biology is calling for submissions to our Collection on key genetic determinants and functional consequences of genome editing interventions in the context of cancer.

Understanding the molecular pathways essential for cancer progression is of paramount importance in advancing both basic research and clinical applications. By employing CRISPR/Cas9 and related methods for targeted genome editing and high-throughput screens, researchers can systematically dissect the genetic determinants of cancer, identify novel therapeutic targets, and enhance our comprehension of the regulatory networks orchestrating oncogenic processes. This brings insights into the functional consequences of genetic alterations, paving the way for the development of personalized and effective cancer treatments.

Through a genome-wide exploration using CRISPR and other editing tools, the Collection aims to offer unprecedented insights into the functional genomic landscape of cancer. It provides a platform for cutting-edge research at the intersection of genome editing technology and cancer biology to advance our understanding of cancer progression by elucidating molecular pathways, identifying key genetic determinants, and exploring the functional consequences of genome editing interventions. Topics of interest include but are not limited to, the following:

Functional genomics approaches and insights
Exploration of tumor suppressor genes and oncogenes
Immune modulation using CRISPR/Cas9 or other editing tools
Combinatorial screens profiling genetic interactions and analytical tools designed for these screens
Targeting the undruggable genome and exploration of novel drug targets

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of original Research, Method, Short Report, Review, and Database article types. Before submitting your manuscript, please ensure you have read our submission guidelines.

To submit your manuscript to this Collection, please use our online submission system and indicate in your covering letter that you would like the article to be considered for inclusion in the "Genome editing and cancer" Collection.

All articles submitted to Collections are peer reviewed in line with the journal’s standard peer review policy and are subject to all of the journal’s standard editorial and publishing policies. This includes the journal’s policy on competing interests.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editor or Editorial Board Member who has no competing interests.