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Genetic disorders and genetic manipulation at the blood-brain barriers

This new thematic series from Fluids and Barriers of the CNS seeks to publish new research and reviews on how genetic and epigenetic changes impact blood-brain barrier, neurovascular unit (NVU) and blood-CSF barrier function. It aims to cover how genetic mutations in humans can impact barrier and NVU function leading to pathology, how experimental gene deletion and overexpression studies provide insights into the barriers and NVU, and how model systems have advanced the field. Human, in vivo animal and in vitro studies on this exciting area of research are welcome.

Deadline for submissions is December 31, 2021

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

  1. Genetic variation in a population has an influence on the manifestation of monogenic as well as multifactorial disorders, with the underlying genetic contribution dependent on several interacting variants. Com...

    Authors: Johanna Schaffenrath, Sheng-Fu Huang, Tania Wyss, Mauro Delorenzi and Annika Keller

    Citation: Fluids and Barriers of the CNS 2021 18:34

    Content type: Research

    Published on:

  2. The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transpo...

    Authors: Stephanie A. Ihezie, Iny Elizebeth Mathew, Devin W. McBride, Ari Dienel, Spiros L. Blackburn and Peeyush Kumar Thankamani Pandit

    Citation: Fluids and Barriers of the CNS 2021 18:17

    Content type: Review

    Published on:

  3. Alzheimer’s disease (AD) is the most common form of neurodegenerative disease. It is an irreversible condition marked by irreversible cognitive loss, commonly attributed to the loss of hippocampal neurons due ...

    Authors: Snehal Raut, Ronak Patel and Abraham J. Al-Ahmad

    Citation: Fluids and Barriers of the CNS 2021 18:3

    Content type: Research

    Published on: