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Gaseous Mediators

Edited by Dr Peter Radermacher

This series of articles in Critical Care has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Series Editor, with final decisions made by the Editor in Chief. The Series Editor and Editor in Chief declare no competing interests.

  1. Molecular oxygen is obviously essential for conserving energy in a form useable for aerobic life; however, its utilization comes at a cost - the production of reactive oxygen species (ROS). ROS can be highly d...

    Authors: Raquel R Bartz and Claude A Piantadosi
    Citation: Critical Care 2010 14:234
  2. Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard, inhibition of mitochondrial respiration resulting from blockade of cytochrome c...

    Authors: Florian Wagner, Pierre Asfar, Enrico Calzia, Peter Radermacher and Csaba Szabó
    Citation: Critical Care 2009 13:213
  3. Nitric oxide (NO) is an endogenous mediator of vascular tone and host defence. Inhaled nitric oxide (iNO) results in preferential pulmonary vasodilatation and lowers pulmonary vascular resistance. The route of...

    Authors: Benedict C Creagh-Brown, Mark JD Griffiths and Timothy W Evans
    Citation: Critical Care 2009 13:221
  4. Oxygen is one of the most commonly used therapeutic agents. Injudicious use of oxygen at high partial pressures (hyperoxia) for unproven indications, its known toxic potential, and the acknowledged roles of re...

    Authors: Haim Bitterman
    Citation: Critical Care 2009 13:205