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The new FTD mutation on chromosome 9

  1. Content type: Editorial

    The clinical, neuropsychiatric and neuroimaging features of patients who carry the important new C9ORF72 mutation are discussed in this special series of Alzheimer's Research & Therapy. First reported in November...

    Authors: Bruce L Miller

    Citation: Alzheimer's Research & Therapy 2013 5:7

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  2. Content type: Review

    Frontotemporal dementia (FTD) is a common dementia syndrome in patients under the age of 65 years with many features overlapping with amyotrophic lateral sclerosis (ALS). The link between FTD and ALS has been ...

    Authors: Sharon J Sha and Adam Boxer

    Citation: Alzheimer's Research & Therapy 2012 4:46

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  3. Content type: Review

    Hexanucleotide expansion intronic to chromosome 9 open reading frame 72 (C9ORF72) has recently been identified as the most common genetic cause of both familial and sporadic amyotrophic lateral sclerosis and of f...

    Authors: Jennifer S Yokoyama and Howard J Rosen

    Citation: Alzheimer's Research & Therapy 2012 4:45

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  4. Content type: Review

    Earlier reports of chromosome 9p-linked frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) kindreds observed psychosis as a prominent feature in some patients. Since the discovery of chromo...

    Authors: Leonel T Takada and Sharon J Sha

    Citation: Alzheimer's Research & Therapy 2012 4:38

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  5. Content type: Commentary

    Mutation in chromosome 9 open reading frame 72 (C9orf72) is a major genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), referred to as C9FTD/ALS. The function of the protein is...

    Authors: Tibor Hortobágyi

    Citation: Alzheimer's Research & Therapy 2012 4:37

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  6. Content type: Research

    Frontotemporal dementia (FTD) is a common cause of early-onset dementia with a significant genetic component, as underlined by the recent identification of repeat expansions in the gene C9ORF72 as a major cause o...

    Authors: Colin J Mahoney, Laura E Downey, Gerard R Ridgway, Jon Beck, Shona Clegg, Melanie Blair, Sarah Finnegan, Kelvin K Leung, Tom Yeatman, Hannah Golden, Simon Mead, Jonathan D Rohrer, Nick C Fox and Jason D Warren

    Citation: Alzheimer's Research & Therapy 2012 4:41

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  7. Content type: Research

    Chromosome 9 open reading frame 72 (C9orf72) is an evolutionarily conserved protein with unknown function, expressed at high levels in the brain. An expanded hexanucleotide GGGGCC repeat located in the first i...

    Authors: Jun-ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Yuko Saito and Kunimasa Arima

    Citation: Alzheimer's Research & Therapy 2012 4:33

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  8. Content type: Research

    An expanded hexanucleotide repeat in the C9ORF72 gene has recently been identified as an important cause of frontotemporal dementia and motor neuron disease; however, the phenotypic spectrum of this entity and it...

    Authors: Laura E Downey, Colin J Mahoney, Martin N Rossor, Sebastian J Crutch and Jason D Warren

    Citation: Alzheimer's Research & Therapy 2012 4:42

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  9. Content type: Review

    Numerous kindreds with familial frontotemporal dementia or amyotrophic lateral sclerosis or both have been linked to chromosome 9 (c9FTD/ALS), and an expansion of the GGGGCC hexanucleotide repeat in the non-co...

    Authors: Bradley F Boeve and Neill R Graff-Radford

    Citation: Alzheimer's Research & Therapy 2012 4:29

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