Edited by: Paul Hagerman, Randi Hagerman, and Flora Tassone
An article collection in Journal of Neurodevelopmental Disorders
Although the core clinical symptoms of fragile X syndrome have been well characterized and generally accepted, our understanding of the clinical issues relating to carriers of premutation forms of the gene are continuing to evolve. Over the past several years there has been increasing recognition of the large spectrum of clinical involvement.
This series of research and review articles stems from the International Conference on the FMR1 premutation which was held in Italy in June of 2013, during which many scientists came together and presented their perspectives and experiences on the subject of the premutation. Thus, this thematic issue highlights the basis for the spectrum of clinical involvement, from neurodevelopmental problems in infancy/childhood to mid-adult disorders, (including FXPOI and psychiatric disorders) and to the late-adult neurodegenerative disorder (FXTAS). Our hope is that the presented articles will stimulate further investigation with the ultimate goal of yielding novel insights on the FMR1-associated disorders, leading to targeted therapeutic approaches for premutation-associated disorders.
This collection of articles has not been sponsored and articles have undergone the journal's standard peer-review process overseen by the Editor-in-Chief and Associate Editors. The Editor-in-Chief and Associate Editors declare no competing interests.